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MicroRNA-199a-3p and microRNA-34a regulate the apoptosis in human osteosarcoma cells (2014)

Y Tian, Y Zhang, W Chen

Portland Press

In: Bioscience Reports

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Publication Date: 2014-06-25

Description: MicroRNAs (MiRNAs) are small non-coding RNAs (18-25nt) that regulate gene expression mainly through affecting post-transcriptional modification. Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. microRNAs (miRNAs) play an important role in cancer cell growth and migration, however, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. In this paper, miR-199a and miR-34a were discussed the mechanisms of apoptosis using micrRNA mimics in human osteosarcoma cells. The results demonstrated that miR-199a and miR-34a could induce the apoptosis of human osteosarcoma cells via p53 signaling pathway.

Print ISSN: 0144-8463

Electronic ISSN: 1573-4935

Topics: Biology , Chemistry and Pharmacology

Published by Portland Press

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