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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 293 (1992), S. 595-621 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0983
    Keywords: Key words Yeast ; Postreplication repair ; UBC13 ; Epistatic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The Ubc13 protein was recently identified for its unique role in ubiquitin (Ub) chain assembly at the Ub Lys-63 residue instead of the conventional Lys-48 residue. This activity requires Ubc13 to form a complex with Mms2 and indeed ubc13 and mms2 mutations have been shown elsewhere to be epistatic with respect to UV sensitivity. The MMS2 gene is known to be a member of the error-free DNA postreplication repair (PRR) pathway. By contrast, the Ub Lys-63 residue has been previously implicated in the error-prone PRR pathway, since yeast cells carrying the ubiK63R mutation are defective in UV-induced mutagenesis. In the present study, we attempted to define the role of UBC13 within the PRR pathway. We found that the ubc13 mutation is epistatic to mms2 and rad6, confirming that UBC13 belongs to the PRR-pathway. We also found that ubc13 is synergistic to the error-prone PRR pathway mutation rev3, indicating that UBC13 is in a pathway alternative to REV3 mutagenesis. The ubc13 mutant displays up to a 30-fold increase in the spontaneous mutation rate, and this increase is largely REV3 dependent. In addition, UV-induced mutagenesis is fully functional in the ubc13 mutant. These results together demonstrate that UBC13 is a member of the error-free PRR pathway. The involvement of UBC13 in cellular tolerance to DNA-damage is further implicated by our finding that the UBC13 transcript level is increased up to 6-fold in response to DNA-damage.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 324-325 (Nov. 2006), p. 1165-1172 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper presents a fracture mechanics analysis in continuously non-homogeneous,isotropic, linear elastic and functionally graded materials (FGMs). A meshless boundary elementmethod (BEM) is developed for this purpose. Young’s modulus of the FGMs is assumed to have anexponential variation, while Poisson’s ratio is taken as constant. Since no simple fundamentalsolutions are available for general FGMs, fundamental solutions for homogeneous, isotropic andlinear elastic solids are used in the present BEM, which contains a domain-integral due to the materialnon-homogeneity. Normalized displacements are introduced to avoid displacement gradients in thedomain-integral. The domain-integral is transformed into a boundary integral along the globalboundary by using the radial integration method (RIM). To approximate the normalizeddisplacements arising in the domain-integral, basis functions consisting of radial basis functions andpolynomials in terms of global coordinates are applied. Numerical results are presented and discussedto show the accuracy and the efficiency of the present meshless BEM
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 503-506 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A Bioglass® reinforced polyethylene (Bioglass®/polyethylene) composite has beenprepared, which combines the high bioactivity of Bioglass® and the toughness of polyethylene. Thespatial distribution of Bioglass® particles within the composite is important for the performance ofcomposites in-vivo. Recent developments in X-ray microtomography (XμT) have made it possibleto visualize internal and microstructural details with different X-ray absorbencies, nondestructively,and to acquire 3D information at high spatial resolution. In this study, the volumefraction and 3D spatial distribution of Bioglass® particles has been acquired quantitatively by XμT.The information obtained provides a foundation for understanding the mechanical and bioactiveproperties of the Bioglass®/polyethylene composites
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 1753-1755 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Silicate fireproof coatings for tunnels (FCT) have many eminent properties. But low adhesionstrength and poor water/fire-resistance of this kind of materials largely limit its applications. Here wereported a new kind of FCT based on high alumina cement as principle adhesive, redispersible powder asassisting adhesive, ammonium polyphosphate as fire-retardant material, vermiculite as adiabatic padding,and magnesium hydroxide as assisting reagents. The influence of various experimental conditions on fireresistance, adhesion strength and water resistance were carefully studied. Results showed that dispersibleemulsoid powder was a key component affecting adhesion strength and water resistance of FCT, whereasfire-retardant material posed significant effects on the fire resistance
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 915-1918 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Computerized X-ray microtomography (micro CT) is a powerful technique for imagingand quantification in biomedical materials research. Mapping of various tissue/implants in3-dimension, which is not achievable with traditional histological slices, is particularly desirable inex-vivo implant analysis. However, due to a variety of artifacts during image formation, especiallythe blurred interfaces due to the machine contrast transfer function and the partial volume effect,quantification based on traditional histograms is not accurate. In this work we propose a new2-dimensional histogram and its application in the analysis of micro CT data of ex-vivo implants,which significantly improve the clarity of the definition of different phases and drastically reducedthe artifacts of segmentation compared to conventional methods
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 336-338 (Apr. 2007), p. 36-38 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Effect of co-doping two different elements and incorporating SrBi2Nb2O9 (SBN) on structureand field-stability of dielectric properties in PMNT ceramics were investigated. Single-phase cubicPerovskite structure is more easily obtained by appropriate co- doping of La3+ and Zn2+. X-ray diffractionpatterns of PMNT/SBN composite showed that there is no SBN grains in PMNT/SBN as a secondaryphase. Co-doping of La3+ and Zn2+ as well as incorporation of SBN markedly increased the field-stabilityof dielectric constant. The mechanism of improving field-stability was tentatively discussed
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 324-325 (Nov. 2006), p. 1261-1264 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this paper, an isotropic elastic damage analysis is presented by using a meshlessboundary element method (BEM) without internal cells. First, nonlinear boundary-domain integralequations are derived by using the fundamental solutions for undamaged, homogeneous, isotropic andlinear elastic solids and the concept of normalized displacements, which results in boundary-domainintegral equations without an involvement of the displacement gradients in the domain-integral. Then,the arising domain-integral due to the damage effects is converted into a boundary integral byapproximating the normalized displacements in the domain-integral by a series of prescribed radialbasis functions (RBF) and using the radial integration method (RIM). The damage variable used in thepaper is the ratio of the damaged area to the total area of the material, and an exponential evolutionequation for the damage variable is adopted. A numerical example is given to demonstrate theefficiency of the present meshless BEM
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 340-341 (June 2007), p. 295-300 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: For researching the terminal ballistic effect of the Fragment Simulation Projectile (FSP),the experiments that A3 steel cylindrical projectiles of 25mm diameter impacting 45 steel plates areconducted. The intensity of A3 steel is less than that of 45 steel. In the velocity ranges of 200m/s~800m/s, Taylor impact, petal-cap failure of Sunflower alike and plugging perforation are observed,respectively. Complicated material failures of projectile and target conflict with the variouspenetration mechanisms
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  • 10
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 539-543 (Mar. 2007), p. 433-437 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Al alloys with Mg as the major alloying element constitute a group of non-heat treatable alloys withmedium strength, high ductility, excellent corrosion resistance and weldability. However, the segregation of Mgmay adversely affect the performance of these materials if they are exposed to rapid heating and coolingenvironments such as resistance spot welding. The formation and migration of vacancy is an important factoraffecting Mg segregation. In this paper, the amount and distribution of Mg were measured by electron probemicroanalysis and the vacancy formation energy in AA5754 alloys was measured by positron annihilationlifetime spectroscopy. The results indicated that the segregation of Mg at cracks, occurring under suitabletemperature and stress conditions, is related to the formation and migration of vacancies, and may promote crackinitiation and propagation
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