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  • 1
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    Long noncoding RNA POU6F2-AS2 is associated with oesophageal squamous cell carcinoma (2016)
    Oxford University Press
    Details
    Publication Date: 2016-10-08
    Description: Oesophageal carcinoma is one of the most lethal cancer types in the world, especially in some part of China. Oesophageal squamous cell carcinoma (OSCC) is a major subtype, which has been shown to be associated with unhealthy diet habit, smoking, environmental carcinogens etc. The OSCC often progress slowly, however, it is often diagnosed at an advanced stage. Thus it is imperative to elucidate the molecular mechanisms involved in the initiation and progression of OSCC. Long noncoding RNAs (lncRNA) has emerged as a novel functional player transcribed from the genome. Here, we describe a novel lncRNA POU6F2-AS2 specifically expressed in OSCC. POU6F2-AS2 is involved in the DNA damage response and regulates cells survival after ionizing radiation. POU6F2-AS2 interacts with Ybx1 protein and regulates its chromatin localization. Our current study represents the first description of an OSCC associated lncRNA that modulates DNA repair.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
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  • 2
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    DEG9 modulates cytokinins and light signaling [Plant Biology] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-06-22
    Description: Cytokinin is an essential phytohormone that controls various biological processes in plants. A number of response regulators are known to be important for cytokinin signal transduction. ARABIDOPSIS RESPONSE REGULATOR 4 (ARR4) mediates the cross-talk between light and cytokinin signaling through modulation of the activity of phytochrome B. However, the mechanism...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains (2015)
    Oxford University Press
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    Publication Date: 2015-04-23
    Description: Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease (AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a key cellular pathway in mitochondrial quality control. Recent studies established that acute depolarization of mitochondrial membrane potential ( m ) using m dissipation reagents in vitro induces Parkin-mediated mitophagy in many non-neuronal cell types or neuronal cell lines. However, neuronal pathways inducing mitophagy, particularly under pathophysiological relevant context in AD mouse models and patient brains, are largely unknown. Here, we reveal, for the first time, that Parkin-mediated mitophagy is robustly induced in mutant hAPP neurons and AD patient brains. In the absence of m dissipation reagents, hAPP neurons exhibit increased recruitment of cytosolic Parkin to depolarized mitochondria. Under AD-linked pathophysiological conditions, Parkin translocation predominantly occurs in the somatodendritic regions; such distribution is associated with reduced anterograde and increased retrograde transport of axonal mitochondria. Enhanced mitophagy was further confirmed in AD patient brains, accompanied with depletion of cytosolic Parkin over disease progression. Thus, aberrant accumulation of dysfunctional mitochondria in AD-affected neurons is likely attributable to inadequate mitophagy capacity in eliminating increased numbers of damaged mitochondria. Altogether, our study provides the first line of evidence that AD-linked chronic mitochondrial stress under in vitro and in vivo pathophysiological conditions effectively triggers Parkin-dependent mitophagy, thus establishing a foundation for further investigations into cellular pathways in regulating mitophagy to ameliorate mitochondrial pathology in AD.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 4
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    Application of Gabor deconvolution to the correction of nonstationarity for reasonable reflectivity estimations (2014)
    Society of Exploration Geophysicists (SEG)
    Details
    Publication Date: 2014-12-03
    Description: Statistical white reflectivity, minimum-phase wavelets, and stationarity are regarded to be three major shortcomings in dealing with the Robinson convolution model. Modern reflectivity inversion methods (e.g., constrained reflectivity inversion) mainly attempt to reduce side effects of the first two assumptions, but most of them overlook the important fact that seismic signals are typically nonstationary. Numerical tests and practical applications have verified that nonstationarity does have great influence on reflectivity estimation and probably would result in misplaced positions or wrongly restored amplitudes for estimated reflectivity. Nonstationarity can be tackled from a perspective of hyperbolic smoothing in Gabor deconvolution. Specially, the energy relationship of hyperbolic strips in a log spectrum can be taken as a quantitative indicator in balancing nonstationarity and conditioning seismic traces to the assumption of unchanging wavelets. Applications to marine seismic data show that balancing nonstationarity finally helps to recover subtle reflectivity information and promotes better displays of geologic features of the subsurface.
    Print ISSN: 1070-485X
    Electronic ISSN: 1938-3789
    Topics: Geosciences
    Published by Society of Exploration Geophysicists (SEG)
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  • 5
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    Application of Polyelectrolyte-Enhanced Ultrafiltration for Rhenium Recovery from Aqueous Solutions (2012)
    Wiley
    Details
    Publication Date: 2012-01-06
    Description: Polyelectrolyte-enhanced ultrafiltration was investigated for rhenium(VII) recovery from aqueous solutions by using polyquaternium-6 (PQ6) as a complexing agent. The effects of the operating parameters on the permeate flux ( J ) and the rhenium rejection coefficient ( R ) were studied. In the process of concentration, J declines slowly and R is about 1. The concentrated solution was used for the decomplexation. It takes 10 min to achieve the decomplexation equilibrium at a chloride ion concentration of 100 mg L –1 . The decomplexation percentage reaches 45.6 %. In the diafiltration process, rhenium is extracted effectively, and the purification of the regenerated PQ6 is satisfactory. The regenerated PQ6 was used to bind rhenium(VII). The binding capacity of the regenerated PQ6 is close to that of fresh PQ6. Polyelectrolyte-enhanced ultrafiltration was originally used to achieve the recovery of rhenium from aqueous solutions with the help of polyquaternium-6. The effects of various operating parameters on the permeate flux and the rhenium rejection coefficient were investigated. The integration of four experiments including concentration, decomplexation, diafiltration and reuse of the regenerated polymer was carried out.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley
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  • 6
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    Phylotranscriptomic analysis of streptophytes [Evolution] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-11-12
    Description: Reconstructing the origin and evolution of land plants and their algal relatives is a fundamental problem in plant phylogenetics, and is essential for understanding how critical adaptations arose, including the embryo, vascular tissue, seeds, and flowers. Despite advances in molecular systematics, some hypotheses of relationships remain weakly resolved. Inferring deep...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Technique evolvement and improvement for better fracture characterization using prestack P-wave seismic data (2014)
    Society of Exploration Geophysicists (SEG)
    Details
    Publication Date: 2014-08-06
    Description: Anisotropic migration has become a routine practice for fracture prediction because of its remarkable capability of suppressing effects of geologic structures while preserving anisotropy induced by fractures. The quality of input seismic gathers is of the first priority among other factors for fracture prediction. Azimuth-sectored migration loses considerable accuracy and reliability because of its coarse and inappropriate manner in dealing with seismic data. A full-azimuth anisotropic migration in surface offset domain provides better efficiency in using data information. Furthermore, full-azimuth anisotropic migration in local angle domain (subsurface angle domain) allows for accurate and reliable exploitation of seismic wavefield information. Finally, influences of the above three anisotropic migration methods on fracture prediction are prescribed with a field example in which validations with formation micro-imager (FMI) information demonstrate that full-azimuth anisotropic migration in local angle domain is the state-of-the-art technique for recovering true properties of subsurface fractures.
    Print ISSN: 1070-485X
    Electronic ISSN: 1938-3789
    Topics: Geosciences
    Published by Society of Exploration Geophysicists (SEG)
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  • 8
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    Seismic diffraction: Removal for better sequence strata and extraction for special geologic targets (2014)
    Society of Exploration Geophysicists (SEG)
    Details
    Publication Date: 2014-08-06
    Description: Traditionally, diffractions are always regarded as a special type of noise, considering that the mechanism of diffraction wavefields is completely different from that of reflection wavefields. Most routine imaging methods, which incline to take the full wavefield as a reflection wavefield, might lead to blurry images, and many useful signals are probably veiled by the influence of seismic diffractions. However, seismic diffractions carry valuable information related to structures and caved reservoirs, and they might cast new light on special understandings about complex geologies of the subsurface. For different imaging purposes, two complementary aspects make use of seismic diffractions. On one hand, a specularity-weighted stack technology images better sequence strata by suppressing diffractions and other noises. On the other hand, diffractions are extracted from dip-angle gathers with generalized Radon transform and then are imaged separately to reveal more potential drilling targets.
    Print ISSN: 1070-485X
    Electronic ISSN: 1938-3789
    Topics: Geosciences
    Published by Society of Exploration Geophysicists (SEG)
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  • 9
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    Research Articles: The responses of soil microbial community and enzyme activities of Phoebe zhennan cultivated under different soil moisture conditions to phosphorus addition (2018)
    Italian Society of Silviculture and Forest Ecology
    Details
    Publication Date: 2018-12-17
    Description: Olatunji OA, Pan K, Tariq A, Zhang L, Wu X, Sun X, Luo H, Song D, Li N THE RESPONSES OF SOIL MICROBIAL COMMUNITY AND ENZYME ACTIVITIES OF PHOEBE ZHENNAN CULTIVATED UNDER DIFFERENT SOIL MOISTURE CONDITIONS TO PHOSPHORUS ADDITION Abstract : The importance of conservation and ecological restoration of the rare and economically important tree Phoebe zhennan is increasingly recognized. To this purpose, phosphorus (P) addition has been proposed to improve soil biological attributes and face the anticipated drought under climate change, though few studies have investigated its effect on the interaction between the soil microorganisms and plant host, as well as on ecosystem productivity. We investigated the effect of P addition on soil chemical properties, microbial communities, and enzyme activities in a soil planted with P. zhennan under two levels of water treatments (optimum water and drought treatments). P additions had no significant effect on microbial communities, dissolved organic nitrogen (DON), pH and soil moisture (SM), though the available P (aP) increased. Compared with no P treatment, alkaline phosphate and β-fructofuranosidase activities increased with P additions in the drought treatment. Drought decreased the total phospholipid-derived fatty acids (PLFAs), arbuscular mycorrhiza fungi (AMF), and fungi PLFAs compared to the well-watered. These findings indicated that P additions does not ameliorate the impact of drought on soil microbial communities and enzyme activities, except alkaline phosphate and β-fructofuranosidase, and P may not be responsible for regulating biochemical processes essential for maintaining the fertility of soil planted with P. zhennan under drought conditions. It is hypothesized that the lack of effects of P addition on the majority of the microbial properties could be due to the soil mechanism employed by P. zhennan to tolerate harsh conditions. Keywords : Alkaline Phosphatase, Biomass, Drought, Enzymes, Microbial, Phoebe zhennan iForest 11 (6): 751-756 (2018) - doi: 10.3832/ifor2725-011 http://iforest.sisef.org/contents/?id=ifor2725-011
    Electronic ISSN: 1971-7458
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Italian Society of Silviculture and Forest Ecology
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  • 10
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    An autoimmune disease variant of IgG1 modulates B cell activation and differentiation (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018
    Description: 〈p〉The maintenance of autoreactive B cells in a quiescent state is crucial for preventing autoimmunity. Here we identify a variant of human immunoglobulin G1 (IgG1) with a Gly〈sup〉396〈/sup〉-〉Arg substitution (hIgG1-G396R), which positively correlates with systemic lupus erythematosus. In induced lupus models, murine homolog Gly〈sup〉390〈/sup〉-〉Arg (G390R) knockin mice generate excessive numbers of plasma cells, leading to a burst of broad-spectrum autoantibodies. This enhanced production of antibodies is also observed in hapten-immunized G390R mice, as well as in influenza-vaccinated human G396R homozygous carriers. This variant potentiates the phosphorylation of the IgG1 immunoglobulin tail tyrosine (ITT) motif. This, in turn, alters the availability of phospho-ITT to trigger longer adaptor protein Grb2 dwell times in immunological synapses, leading to hyper–Grb2–Bruton’s tyrosine kinase (Btk) signaling upon antigen binding. Thus, the hIgG1-G396R variant is important for both lupus pathogenesis and antibody responses after vaccination.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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