Publication Date:
2015-08-27
Description:
Article Transcription, like DNA replication, is an error-prone process. Vermulst et al. show that transcription errors increase with age in yeast, and find that prematurely increasing the error rate overwhelms the proteotoxic stress response, allowing aggregation-prone proteins to escape protein quality control. Nature Communications doi: 10.1038/ncomms9065 Authors: Marc Vermulst, Ashley S. Denney, Michael J. Lang, Chao-Wei Hung, Stephanie Moore, Arthur M. Mosely, William J. Thompson, Victoria Madden, Jacob Gauer, Katie J. Wolfe, Daniel W. Summers, Jennifer Schleit, George L. Sutphin, Suraiya Haroon, Agnes Holczbauer, Joanne Caine, James Jorgenson, Douglas Cyr, Matt Kaeberlein, Jeffrey N. Strathern, Mara C. Duncan, Dorothy A. Erie
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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