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  • 1
    Monograph available for loan
    Monograph available for loan
    Amsterdam : Elsevier
    Call number: M 18.91612
    Description / Table of Contents: Front Cover -- Machine Learning Techniques for Space Weather -- Copyright -- Contents -- Contributors -- Introduction -- Machine Learning and Space Weather -- Scope and Structure of the Book -- Acknowledgments -- References -- Part I: Space Weather -- Chapter 1: Societal and Economic Importance of Space Weather -- 1 What is Space Weather? -- 2 Why Now? -- 3 Impacts -- 3.1 Geomagnetically Induced Currents -- 3.2 Global Navigation Satellite Systems -- 3.3 Single-Event Effects -- 3.4 Other Radio Systems -- 3.5 Satellite Drag -- 4 Looking to the Future -- 5 Summary and Conclusions -- Acknowledgments -- References -- Chapter 2: Data Availability and Forecast Products for Space Weather -- 1 Introduction -- 2 Data and Models Based on Machine Learning Approaches -- 3 Space Weather Agencies -- 3.1 Government Agencies -- 3.1.1 NOAA's Data and Products -- 3.1.2 NASA -- 3.1.3 European Space Agency -- 3.1.4 The US Air Force Weather Wing -- 3.2 Academic Institutions -- 3.2.1 Kyoto University, Japan -- 3.2.2 Rice University, USA -- 3.2.3 Laboratory for Atmospheric and Space Physics, USA -- 3.3 Commercial Providers -- 3.4 Other Nonprofit, Corporate Research Agencies -- 3.4.1 USGS -- 3.4.2 JHU Applied Physics Lab -- 3.4.3 US Naval Research Lab -- 3.4.4 Other International Service Providers -- 4 Summary -- References -- Part II: Machine Learning -- Chapter 3: An Information-Theoretical Approach to Space Weather -- 1 Introduction -- 2 Complex Systems Framework -- 3 State Variables -- 4 Dependency, Correlations, and Information -- 4.1 Mutual Information as a Measure of Nonlinear Dependence -- 4.2 Cumulant-Based Cost as a Measure of Nonlinear Dependence -- 4.3 Causal Dependence -- 4.4 Transfer Entropy and Redundancy as Measures of Causal Relations -- 4.5 Conditional Redundancy -- 4.6 Significance of Discriminating Statistics
    Description / Table of Contents: 4.7 Mutual Information and Information Flow -- 5 Examples From Magnetospheric Dynamics -- 6 Significance as an Indicator of Changes in Underlying Dynamics -- 6.1 Detecting Dynamics in a Noisy System -- 6.2 Cumulant-Based Information Flow -- 7 Discussion -- 8 Summary -- Acknowledgments -- References -- Chapter 4: Regression -- 1 What is Regression? -- 2 Learning From Noisy Data -- 2.1 Prediction Errors -- 2.2 A Probabilistic Set-Up -- 2.3 The Least Squares Method for Linear Regression -- 2.3.1 The Least Squares Method and the Best Linear Predictor -- 2.3.2 The Least Squares Method and the Maximum Likelihood Principle -- 2.3.3 A More General Approach and Higher-Order Predictors -- 2.4 Overfitting -- 2.4.1 The Order Selection Problem -- Error Decomposition: The Bias Versus Variance Trade-Off -- Some Popular Order Selection Criteria -- 2.4.2 Regularization -- 2.5 From Point Predictors to Interval Predictors -- 2.5.1 Distribution-Free Interval Predictors -- 2.6 Probability Density Estimation -- 3 Predictions Without Probabilities -- 3.1 Approximation Theory -- Dense Sets -- Best Approximator -- 3.1.1 Neural Networks -- The Backpropagation Algorithm: High-Level Idea -- Multiple Layers Networks (Deep Networks) -- 4 Probabilities Everywhere: Bayesian Regression -- 4.1 Gaussian Process Regression -- 5 Learning in the Presence of Time: Identification of Dynamical Systems -- 5.1 Linear Time-Invariant Systems -- 5.2 Nonlinear Systems -- References -- Chapter 5: Supervised Classification: Quite a Brief Overview -- 1 Introduction -- 1.1 Learning, Not Modeling -- 1.2 An Outline -- 2 Classifiers -- 2.1 Preliminaries -- 2.2 The Bayes Classifier -- 2.3 Generative Probabilistic Classifiers -- 2.4 Discriminative Probabilistic Classifiers -- 2.5 Losses and Hypothesis Spaces -- 2.5.1 0-1 Loss -- 2.5.2 Convex Surrogate Losses
    Description / Table of Contents: 2.5.3 Particular Surrogate Losses -- 2.6 Neural Networks -- 2.7 Neighbors, Trees, Ensembles, and All that -- 2.7.1 k Nearest Neighbors -- 2.7.2 Decision Trees -- 2.7.3 Multiple Classifier Systems -- 3 Representations and Classifier Complexity -- 3.1 Feature Transformations -- 3.1.1 The Kernel Trick -- 3.2 Dissimilarity Representation -- 3.3 Feature Curves and the Curse of Dimensionality -- 3.4 Feature Extraction and Selection -- 4 Evaluation -- 4.1 Apparent Error and Holdout Set -- 4.2 Resampling Techniques -- 4.2.1 Leave-One-Out and k-Fold Cross-Validation -- 4.2.2 Bootstrap Estimators -- 4.2.3 Tests of Significance -- 4.3 Learning Curves and the Single Best Classifier -- 4.4 Some Words About More Realistic Scenarios -- 5 Regularization -- 6 Variations on Standard Classification -- 6.1 Multiple Instance Learning -- 6.2 One-Class Classification, Outliers, and Reject Options -- 6.3 Contextual Classification -- 6.4 Missing Data and Semisupervised Learning -- 6.5 Transfer Learning and Domain Adaptation -- 6.6 Active Learning -- Acknowledgments -- References -- Part III: Applications -- Chapter 6: Untangling the Solar Wind Drivers of the Radiation Belt: An Information Theoretical Approach -- 1 Introduction -- 2 Data Set -- 3 Mutual Information, Conditional Mutual Information, and Transfer Entropy -- 4 Applying Information Theory to Radiation Belt MeV Electron Data -- 4.1 Radiation Belt MeV Electron Flux Versus Vsw -- 4.2 Radiation Belt MeV Electron Flux Versus nsw -- 4.3 Anticorrelation of Vsw and nsw and Its Effect on Radiation Belt -- 4.4 Ranking of Solar Wind Parameters Based on Information Transfer to Radiation Belt Electrons -- 4.5 Detecting Changes in the System Dynamics -- 5 Discussion -- 5.1 Geo-Effectiveness of Solar Wind Velocity -- 5.2 nsw and Vsw Anticorrelation
    Description / Table of Contents: 5.3 Geo-Effectiveness of Solar Wind Density -- 5.4 Revisiting the Triangle Distribution -- 5.5 Improving Models With Information Theory -- 5.5.1 Selecting Input Parameters -- 5.5.2 Detecting Nonstationarity in System Dynamics -- 5.5.3 Prediction Horizon -- 6 Summary -- Acknowledgments -- References -- Chapter 7: Emergence of Dynamical Complexity in the Earth's Magnetosphere -- 1 Introduction -- 2 On Complexity and Dynamical Complexity -- 3 Coherence and Intermittent Features in Time Series Geomagnetic Indices -- 4 Scale-Invariance and Self-Similarity in Geomagnetic Indices -- 5 Near-Criticality Dynamics -- 6 Multifractional Features and Dynamical Phase Transitions -- 7 Summary -- Acknowledgments -- References -- Chapter 8: Applications of NARMAX in Space Weather -- 1 Introduction -- 2 NARMAX Methodology -- 2.1 Forward Regression Orthogonal Least Square -- 2.2 The Noise Model -- 2.3 Model Validation -- 2.4 Summary -- 3 NARMAX and Space Weather Forecasting -- 3.1 Geomagnetic Indices -- 3.1.1 SISO Dst Index -- 3.1.2 Continuous Time Dst model -- 3.1.3 MISO Dst -- 3.1.4 Kp Index -- 3.2 Radiation Belt Electron Fluxes -- 3.2.1 GOES High Energy -- 3.2.2 SNB3GEO Comparison With NOAA REFM -- 3.2.3 GOES Low Energy -- 3.3 Summary of NARMAX Models -- 4 NARMAX and Insight Into the Physics -- 4.1 NARMAX Deduced Solar Wind-Magnetosphere Coupling Function -- 4.2 Identification of Radiation Belt Control Parameters -- 4.2.1 Solar Wind Density Relationship With Relativistic Electrons at GEO -- 4.2.2 Geostationary Local Quasilinear Diffusion vs. Radial Diffusion -- 4.3 Frequency Domain Analysis of the Dst Index -- 5 Discussions and Conclusion -- References -- Chapter 9: Probabilistic Forecasting of Geomagnetic Indices Using Gaussian Process Models -- 1 Geomagnetic Time Series and Forecasting -- 2 Dst Forecasting
    Description / Table of Contents: 2.1 Models and Algorithms -- 2.2 Probabilistic Forecasting -- 3 Gaussian Processes -- 3.1 Gaussian Process Regression: Formulation -- 3.2 Gaussian Process Regression: Inference -- 4 One-Hour Ahead Dst Prediction -- 4.1 Data Source: OMNI -- 4.2 Gaussian Process Dst Model -- 4.3 Gaussian Process Auto-Regressive (GP-AR) -- 4.4 GP-AR With eXogenous Inputs (GP-ARX) -- 5 One-Hour Ahead Dst Prediction: Model Design -- 5.1 Choice of Mean Function -- 5.2 Choice of Kernel -- 5.3 Model Selection: Hyperparameters -- 5.3.1 Grid Search -- 5.3.2 Coupled Simulated Annealing -- 5.3.3 Maximum Likelihood -- 5.4 Model Selection: Auto-Regressive Order -- 6 GP-AR and GP-ARX: Workflow Summary -- 7 Practical Issues: Software -- 8 Experiments and Results -- 8.1 Model Selection and Validation Performance -- 8.2 Comparison of Hyperparameter Selection Algorithms -- 8.3 Final Evaluation -- 8.4 Sample Predictions With Error Bars -- 9 Conclusion -- References -- Chapter 10: Prediction of MeV Electron Fluxes and Forecast Verification -- 1 Relativistic Electrons in Earth's Outer Radiation Belt -- 1.1 Source, Loss, Transport, and Acceleration, Variation -- 2 Numerical Techniques in Radiation Belt Forecasting -- 3 Relativistic Electron Forecasting and Verification -- 3.1 Forecast Verification -- 3.2 Relativistic Electron Forecasting -- 4 Summary -- References -- Chapter 11: Artificial Neural Networks for Determining Magnetospheric Conditions -- 1 Introduction -- 2 A Brief Review of ANNs -- 3 Methodology and Application -- 3.1 The DEN2D Model -- 4 Advanced Applications -- 4.1 The DEN3D Model -- 4.2 The Chorus and Hiss Wave Models -- 4.3 Radiation Belt Flux Modeling -- 5 Summary and Discussion -- Acknowledgments -- References -- Chapter 12: Reconstruction of Plasma Electron Density From Satellite Measurements Via Artificial Neural Networks
    Description / Table of Contents: 1 Overview
    Type of Medium: Monograph available for loan
    Pages: xviii, 433 Seiten , Illustrationen
    ISBN: 978-0-12-811788-0
    Classification:
    Geophysics
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Call number: ZSP-599-150
    In: Rapportserie / Norsk Polarinstitutt, (DE-B103)114733
    Type of Medium: Series available for loan
    Pages: 325 Seiten , Illustrationen, Karten, Diagramme
    ISBN: 9788276664119 , 9788276664126
    Series Statement: Rapportserie / Norsk Polarinstitutt nr. 150
    Language: Norwegian
    Note: In norwegischer Sprache
    Location: AWI Reading room
    Branch Library: AWI Library
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  • 3
    Monograph available for loan
    Monograph available for loan
    Boston [u.a.] : McGraw-Hill Higher Education
    Call number: PIK B 020-01-0455
    Type of Medium: Monograph available for loan
    Pages: 668 p.
    Edition: 3. ed.
    ISBN: 0072343524
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmaceutical chemistry. ; Medicine Research. ; Biology Research. ; Medical sciences. ; Biomaterials. ; Biology Technique. ; Pharmaceutics. ; Biomedical Research. ; Health Sciences. ; Biomaterials. ; Biological Techniques.
    Description / Table of Contents: Preface -- Part I: Fundamentals of Systemic Delivery -- Anti-aging medicine: new concepts and intervention development,- Roles of systemic delivery in the development of anti-aging therapies -- Pharmacokinetics and pharmacodynamics in drug delivery -- Physiological, biochemical, and chemical barriers to systemic delivery -- Partt II: Development of Delivery Technologies for Systemic Delivery -- Use of prodrugs for systemic delivery in anti-aging medicine -- Use of physical methods for systemic delivery in anti-aging medicine -- Use of viral systems for systemic delivery in anti-aging medicine -- Use of non-viral biological systems for systemic delivery in anti-aging medicine -- Use of lipid-based systems for systemic delivery in anti-aging medicine -- Use of polymeric systems for systemic delivery in anti-aging medicine -- Use of inorganic nanoparticles for systemic delivery in anti-aging medicine -- Part III: Practical Considerations in Intervention Execution -- Strategies in carrier design to enhance systemic delivery -- Characterization techniques for studying the properties of the carriers -- In vivo assessment of the efficiency of systemic delivery in anti-aging medicine -- Selection of administration routes for systemic delivery in anti-aging medicine -- Intellectual property and regulatory issues in drug delivery research -- Index.
    Abstract: This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.
    Type of Medium: Online Resource
    Pages: XVI, 511 p. 128 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030544904
    Series Statement: Healthy Ageing and Longevity, 13
    DDC: 615.19
    Language: English
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  • 5
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
  • 7
    Publication Date: 2016-09-19
    Description: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy with a unique geographical distribution. The genomic abnormalities leading to NPC pathogenesis remain unclear. In total, 135 NPC tumors were examined to characterize the mutational landscape using whole-exome sequencing and targeted resequencing. An APOBEC cytidine deaminase mutagenesis signature was revealed in the somatic mutations. Noticeably, multiple loss-of-function mutations were identified in several NF-κB signaling negative regulators NFKBIA, CYLD, and TNFAIP3. Functional studies confirmed that inhibition of NFKBIA had a significant impact on NF-κB activity and NPC cell growth. The identified loss-of-function mutations in NFKBIA leading to protein truncation contributed to the altered NF-κB activity, which is critical for NPC tumorigenesis. In addition, somatic mutations were found in several cancer-relevant pathways, including cell cycle-phase transition, cell death, EBV infection, and viral carcinogenesis. These data provide an enhanced road map for understanding the molecular basis underlying NPC.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2014-06-16
    Print ISSN: 0163-3864
    Electronic ISSN: 1520-6025
    Topics: Chemistry and Pharmacology
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  • 9
    Publication Date: 1997-05-01
    Print ISSN: 0020-1669
    Electronic ISSN: 1520-510X
    Topics: Chemistry and Pharmacology
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  • 10
    Publication Date: 2008-07-01
    Print ISSN: 0020-1669
    Electronic ISSN: 1520-510X
    Topics: Chemistry and Pharmacology
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