Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract Three alleles of the Zw locus of Drosophila melanogaster—Zw A, ZwB,and Zw lol—apparently code for dimeric, tetrameric, and monomeric forms of glucose-6-phosphate dehydrogenase (G6PD), respectively. The three forms of G6PD are characterized by different apparent K mvalues for glucose-6-phosphate but similar apparent K mvalues for NAPD+. When high concentrations of NAPD+ were added to enzyme preparations, the Zw Aand Zw lolforms of G6PD assumed tetrameric and dimeric properties, respectively. Although Zw loladults exhibit little G6PD activity, they maintain levels of G6PD-antigen comparable to those in Zw Aand Zw Badults. Thus the low level of G6PD activity in Zw lolindividuals cannot be explained as the consequence of lack of synthesis of the G6PD subunit.
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