ISSN:
0021-9304
Keywords:
bioactive glass
;
histology
;
biomechanics
;
cancellous bone defect
;
rabbit
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
The bioactive glass known as Bioglass® or Perioglass® (USB) (US Biomaterials, Alachua, FL) has proven to be an effective graft material owing to the apatite layer which forms on the surface of the glass, promoting bone formation. USB particles range in size from 90 to 710 μm in diameter, as determined by optical microscopy. A similar bioactive material, BioGran (OV) (Orthovita, Malvern, PA), was developed to limit the particle size of 45S5 to the range between 300 and 360 μm, as determined by sieving. The objective of this study was to histologically and biomechanically compare the 45S5 bioactive glass, produced by US Biomaterials, in a wide particle range (USB) to the narrower particle range glass produced by Orthovita (OV). The grafted defects will then be compared to normal cancellous bone (NORM) of the distal femur in rabbits. Histologically, more bone was quantified at both 4 and 12 weeks within the defects filled with USB and NORM when compared to the limbs filled with OV (p 〈 0.05). The OV particles had greater particle axes and larger particle areas on average than the USB particles (p 〈 0.05). However, the particle axis and area of the two materials decreased with time at a similar rate. Biomechanically, the USB- and OV-grafted defects had comparable peak compressive load, compressive stiffness, and compressive modulus which were equivalent to normal bone. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 41, 527-533, 1998.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
Permalink