Publication Date:
2015-01-25
Description:
Article Neurological disorders such as temporal lobe epilepsy (TLE) are known to be regulated by gene networks. In this study, the authors describe a genome-wide approach that uses samples of hippocampal tissue from patients with TLE, to identify the gene Sestrin 3 ( SESN3 ) as a positive regulator of the disease. Nature Communications doi: 10.1038/ncomms7031 Authors: Michael R. Johnson, Jacques Behmoaras, Leonardo Bottolo, Michelle L. Krishnan, Katharina Pernhorst, Paola L. Meza Santoscoy, Tiziana Rossetti, Doug Speed, Prashant K. Srivastava, Marc Chadeau-Hyam, Nabil Hajji, Aleksandra Dabrowska, Maxime Rotival, Banafsheh Razzaghi, Stjepana Kovac, Klaus Wanisch, Federico W. Grillo, Anna Slaviero, Sarah R. Langley, Kirill Shkura, Paolo Roncon, Tisham De, Manuel Mattheisen, Pitt Niehusmann, Terence J. O’Brien, Slave Petrovski, Marec von Lehe, Per Hoffmann, Johan Eriksson, Alison J. Coffey, Sven Cichon, Matthew Walker, Michele Simonato, Bénédicte Danis, Manuela Mazzuferi, Patrik Foerch, Susanne Schoch, Vincenzo De Paola, Rafal M. Kaminski, Vincent T. Cunliffe, Albert J. Becker, Enrico Petretto
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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