Springer Online Journal Archives 1860-2000
Summary The addition productsof 2 M N-alkyl substituted maleinimides with 1M asymmetric diphenylethylen and some of its substitution products were reduced with LiAlH4 to give amines of the structure V. These substances produce coronary dilation on the isolated guinea-pig heart perfused according to the method of Langendorff, a few of them being more active than papaverin. On the barbiturate anaesthetized dog, however, the activity was much less than that of papaverin after intraarterial injection and was entirely absent on intravenous application. High doses caused lowering of the blood pressure. The limited value of the Langendorff heart preparation for screening coronary dilators is emphasized.
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