Publication Date:
1980-04-25
Description:
DNA synthesis and mitosis in frog lens epithelium are abolished by hypophysectomy and restored by somatomedin C. Both growth hormone and triiodothyronine also restore lens cell proliferation in vivo but not in vitro. Somatomedin-like activity in frog serum is diminished by hypophysectomy and is restored by growth hormone and triiodothyronine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rothstein, H -- Van Wyk, J J -- Hayden, J H -- Gordon, S R -- Weinsieder, A -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):410-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189293" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anura
;
Cell Cycle/*drug effects
;
DNA Replication/drug effects
;
Epithelial Cells
;
Growth Hormone/pharmacology
;
*Hypophysectomy
;
Insulin-Like Growth Factor I
;
Interphase/drug effects
;
Lens, Crystalline/*cytology
;
Metamorphosis, Biological
;
Mitosis/drug effects
;
Somatomedins/blood/*pharmacology
;
Triiodothyronine/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink