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Non-enzymatic glycation of histones (1993)

Liebich, H. M. ; Gesele, E. ; Wirth, C. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 22 (1993), S. 121-123

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ISSN: 1052-9306

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: 2-(2-Furoyl)-5-(2-furanyl)-1H-imidazole (FFI) is detected in total histones and the lysine-rich histone 1 fraction isolated from calf thymus after in vitro glycation and hydrolysis with HCl, using gas chromatographic/mass spectrometric analysis. The finding suggests that glucose is bound to the ∊-amino groups of the lysine residues of the histones. No FFI is monitored in native histone samples.

Additional Material: 2 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/bms.1200220204

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