Springer Online Journal Archives 1860-2000
Abstract. Polymorphisms in the vitamin D receptor (VDR) gene have been analyzed in several studies for an association with prostate cancer (PCA) and odds ratios (OR) ≥3 have been observed in study populations from North America. We studied three polymorphisms in the VDR gene (poly-A microsatellite, TaqI and FokI RFLPs) in 105 controls and 132 sporadic PCA cases from France and in a collection of families from Germany and France. The polymorphisms near the 3' end of the gene were in linkage disequilibrium with an almost complete coincidence of the short poly-A alleles and t (presence of the restriction site) of the TaqI polymorphism, (contingency tables, P〈0.0001). An association was found by logistic regression for the poly-A between PCA and the heterozygous genotype (S/L; S〈17, L≥17, OR=0.44, 95% confidence interval, CI=0.198–0.966, P=0.041). OR was lower in patients ≤70 years old and patients with a Gleason score ≥6. The Tt genotype of the TaqI RFLP also showed an association with PCA (OR=0.5, CI=0.27–0.92, P=0.026). This association was also stronger for patients ≤70 years old (OR=0.31, CI=0.15–0.63, P=0.001). The risk alleles were S and t alleles as indicated by the OR of the homozygotes, although these were not significant. The FokI RFLP at the 5' end of the gene did not reveal any association (P〉0.7). While some association studies differ between Europe and North America, our present findings with the VDR gene agree with those from North America, indicating a weak but general role of the VDR in PCA susceptibility.
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