ISSN:
1573-8388
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary In the Birch reduction of steroid compounds with a phenylbutadiene grouping, i.e., the ketal of 3-methoxy-Δ1, 3, 5(10), 8, 14-D-homoestrapentaen-17a-one (III), the corresponding ketone (IIIa), and 3-methoxy-Δ1, 3, 5(10), 8, 14-D-homoestrapentaen-17aβ-ol (VI), 1, 4 addition of the hydrogen takes place first, and is followed by reduction of the aromatic nucleus. In this way, 3-methoxy-Δ1, 3, 5(10), 8(14)-D-homoestratetraenone (XII), Δ4, 8(14)-19-nor-D-homoandrostadienedione (VIII), and Δ4, 8(14)-19-nor-D-homoandrostadien-17aβ-ol-3-one (IX) have been obtained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00571572
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