ISSN:
1573-739X
Keywords:
Bronchitis
;
Drug evaluation
;
Drug interactions
;
Minimum inhibitory concentrations
;
Pharmacokinetics
;
Quinolones
;
Side effects
;
Theophylline
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Results are presented from 186 hospitalized patients treated for acute purulent exacerbations of chronic bronchitis with orally administered ciprofloxacin (80 patients), enoxacin (26 patients), ofloxacin (30 patients) or pefloxacin (50 patients). In general, good clinical results were observed in 50–70% of the patients treated, most failures being due to relapses or reinfections withStreptococcus pneumoniae orPseudomonas aeruginosa. Studies on blood and sputum concentration suggested that gastro-intestinal absorption was not always satisfactory. Unwanted drug effects were noted with all agents studied, generally presenting as stomach pain, nausea, hallucinations, or dizziness. Most adverse drug reactions were seen with enoxacin, often but not always during concomitant treatment with theophylline.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01975481
Permalink
