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  • 1
    Online Resource
    Online Resource
    Cullin-RING Ligases and Protein Neddylation : Biology and Therapeutics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Post-translational modification. ; Cytology. ; Biomedical Research. ; Post-translational Modifications. ; Cell Biology.
    Description / Table of Contents: Chapter 1 Introduction of Protein Ubiquitination and Cullin/RING Ubiquitin Ligases: introduce the protein ubiquitination system briefly; discuss the family of Cullin/RING Ubiquitin Ligases -- Chapter 2 Assembly and Regulation of CRL ubiquitin ligases: discuss the assembly process of CRL ubiquitin ligases by CAND1; elaborate the regulation of CRL ubiquitin ligases by neddylation -- Chapter 3 Protein structure of CRL and Neddylation complex -- Chapter 4 The roles of CRL ubiquitin ligases and neddylation in human diseases -- Chapter 5 The roles of CRL ubiquitin ligases in stem cell biology: Briefly introduce concept and potential application of stem cells; analyze a few example for CRL ubiquitin ligases to control stem cell biology -- Chapter 6 The biology of F-box proteins: introduce the history of SCF ubiquitin ligases; discuss the overall functions of F-box proteins (emphasize phospho-degron concept) -- Chapter 7 The roles of Fbxw7 in human diseases: discuss the roles of Fbw7 in cancer; elaborate the roles of Fbxw7 in other diseases -- Chapter 8 Mouse models of CRL1 components to study their biological function -- Chapter 9 Cullin2 and cancer: introduce Cullin2 ubiquitin ligases; discuss VHL ubiquitin ligase and its roles in cancer -- Chapter 10 Cullin3 and tumorigenesis: introduce Cullin3 ubiquitin ligases; discuss a few examples of Cullin3 ubiquitin ligases in control of tumorigenesis -- Chapter 11 Cullin4-DCAF proteins in tumorigenesis: Discovery of DCAF proteins; discuss a few examples of DCAF’s biological functions -- Chapter 12 Cullin4 ubiquitin ligases in DNA damage responses: Introduce Cullin4 ubiquitin ligases; discuss the roles of Cullin4 ubiquitin ligases in DNA damage responses -- Chapter 13 Coordinating the roles of Cullin5 ubiquitin ligases by SAG and UBE2F: introduce Cullin5 ubiquitin ligases; discuss how SGA and UBE2F mediates the functions of Cullin5 -- Chapter 14 Cullin5 in anti-virus infection: mechanism and drug target -- Chapter 15 The roles of Cul7 in cancer biology: introduce Cullin7 ubiquitin ligase7; discuss a few examples of Cullin7 ubiquitin ligases in cancer -- Chapter 16 Coordinating functions of p97 and CRL ubiquitin ligases in protein turnover: introduce the interactions between p97 and CRL ubiquitin ligases; discuss the coordinating roles between p97 and CRL ubiquitin ligases in protein turnover -- Chapter 17 Interaction between CRL ubiquitin ligases and COP9 Signalosome: introduce Cop9 signalosome; discuss how Cop9 signalosome regulates CRL ubiquitin ligases -- Chapter 18 Drug discovery effort to target Cullin-3 neddylation: discuss inhibitor of Cullin3 neddylation and its application -- Chapter 19 Targeting neddylation modification: Briefly introduce protein neddylation; discuss the roles of neddylation in cancer -- Chapter 20 Targeting CRL ubiquitin ligases: discuss current progress in targeting CRL ubiquitin ligases; discuss the application of CRL ubiquitin ligases in Protac drug development.
    Abstract: This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
    Type of Medium: Online Resource
    Pages: VIII, 372 p. 119 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510250
    Series Statement: Advances in Experimental Medicine and Biology, 1217
    URL: https://doi.org/10.1007/978-981-15-1025-0
    DOI: 10.1007/978-981-15-1025-0
    DDC: 610.72
    Language: English
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    E-BOOKS (AWI ONLY)
  • 2
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    Natural blue zircon from Vesuvius (2020)
    Springer Vienna
    Details
    Publication Date: 2023-06-23
    Description: Zircon from syenitic ejecta of Vesuvius (Campania, Italy) is unusually blue, a property shared with gem zircon from Ratanakiri province (Cambodia), which turns from natural reddish-brown to blue when heated under reducing conditions. Here, the origins of these unusual crystals were traced through geochronology, trace elements, and O-Hf isotopic compositions. The causes of its colour were investigated through optical and electron microscopy, optical absorption spectroscopy, and Raman microspectroscopy. Colour stability upon heating and ultraviolet light (UV) exposure was tested using Ratanakiri zircon as a control. Vesuvius zircon contains vesiculated zones with abundant inclusions ~2.5 μm to 〈100 nm in diameter (mostly U-rich thorianite and pyrochlore-group minerals), while homogeneous zircon domains are high in Th and U (up to 5.9 and 1.8 wt%, respectively). Its blue colouration is stable under UV radiation, as well as heat-treatment under reducing conditions (1000 °C; 〉15 h). Turbid domains rich in large inclusions change to yellow-brown after heating under oxidizing conditions, while transparent domains remain pale blue or colourless. Optical absorption spectra display sharp absorption lines attributed to U4+, and slightly elevated absorption towards shorter wavelengths. The ~1007 cm−1 ν3(SiO4) Raman band is broadened due to lattice distortion by non-stoichiometric elements in high-Th/-U zircon, whereas narrow bands in inclusion-rich domains indicate a decrease in lattice strain due to inclusion precipitation. Blue colouration in Vesuvius zircon is explained by the effect of light scattering (Rayleigh and/or Mie scattering) on highly refractive actinide-rich inclusions ranging in size from 〈1/10 to few multiples of the wavelengths of visible light. Inclusions likely formed during fluid-mediated coupled dissolution-reprecipitation that locally transformed lattice-strained actinide-rich zircon within several hundreds of years prior to eruption.
    Description: Ruprecht-Karls-Universität Heidelberg (1026)
    Keywords: ddc:549 ; Blue zircon ; Vesuvius ; Rayleigh/Mie scattering ; Optical absorption ; Raman microspectroscopy ; Mineral inclusions ; Syenite
    Language: English
    Type: doc-type:article
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    CITATION GEO-LEO
  • 3
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    Quantification of excess 231Pa in late Quaternary igneous baddeleyite (2020)
    Mineralogical society of America
    Details
    Publication Date: 2020-12-14
    Description: Initial excess protactinium (231Pa) is a frequently suspected source of discordance in baddeleyite (ZrO2) geochronology, which limits accurate U/Pb dating, but such excesses have never been directly demonstrated. In this study, Pa incorporation in late Holocene baddeleyite from Somma-Vesuvius (Campanian Volcanic Province, central Italy) and Laacher See (East Eifel Volcanic Field, western Germany) was quantified by U-Th-Pa measurements using a large-geometry ion microprobe. Bad- deleyite crystals isolated from subvolcanic syenites have average U concentrations of ~200 ppm and are largely stoichiometric with minor abundances of Nb, Hf, Ti, and Fe up to a few weight percent. Measured (231Pa)/(235U) activity ratios are significantly above the secular equilibrium value of unity and range from 3.4(8) to 14.9(2.6) in Vesuvius baddeleyite and from 3.6(9) to 8.9(1.4) in Laacher See baddeleyite (values within parentheses represent uncertainties in the last significant figures reported as 1σ throughout the text). Crystallization ages of 5.12(56) ka (Vesuvius; MSWD = 0.96, n = 12) and 15.6(2.0) ka (Laacher See; MSWD = 0.91, n = 10) were obtained from (230Th)/(238U) disequilibria for the same crystals, which are close to the respective eruption ages. Applying a corresponding age correction indicates average initial (231Pa)/(235U)0 of 8.8(1.0) (Vesuvius) and 7.9(5) (Laacher See). For reasonable melt activities, model baddeleyite-melt distribution coefficients of DPa/DU = 5.8(2) and 4.1(2) are obtained for Vesuvius and Laacher See, respectively. Speciation-dependent (Pa4+ vs. Pa5+) partitioning coefficients (D values) from crystal lattice strain models for tetra- and pentavalent proxy ions significantly exceed DPa/DU inferred from direct analysis of 231Pa for Pa5+. This is consistent with predominantly reduced Pa4+ in the melt, for which D values similar to U4+ are expected. Contrary to common assumptions, baddeleyite-crystallizing melts from Vesuvius and Laacher See appear to be dominated by Pa4+ rather than Pa5+. An initial disequilibrium correction for baddeleyite geochronology using DPa/DU = 5 ± 1 is recommended for oxidized phonolitic melt compositions.
    Description: Published
    Description: 1830-1840
    Description: 1V. Storia eruttiva
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: 3V. Proprietà chimico-fisiche dei magmi e dei prodotti vulcanici
    Description: JCR Journal
    Keywords: 04.08. Volcanology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 4
    facet.materialart.
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    Natural blue zircon from Vesuvius (2020)
    Springer
    Details
    Publication Date: 2021-01-20
    Description: Zircon from syenitic ejecta of Vesuvius (Campania, Italy) is unusually blue, a property shared with gem zircon from Ratanakiri province (Cambodia), which turns from natural reddish-brown to blue when heated under reducing conditions. Here, the origins of these unusual crystals were traced through geochronology, trace elements, and O-Hf isotopic compositions. The causes of its colour were investigated through optical and electron microscopy, optical absorption spectroscopy, and Raman microspectroscopy. Colour stability upon heating and ultraviolet light (UV) exposure was tested using Ratanakiri zircon as a control. Vesuvius zircon contains vesiculated zones with abundant inclusions ~2.5 μm to 〈100 nm in diameter (mostly U-rich thorianite and pyrochlore-group minerals), while homogeneous zircon domains are high in Th and U (up to 5.9 and 1.8 wt%, respectively). Its blue colouration is stable under UV radiation, as well as heat-treatment under reducing conditions (1000 °C; 〉15 h). Turbid domains rich in large inclusions change to yellow-brown after heating under oxidizing conditions, while transparent domains remain pale blue or colourless. Optical absorption spectra display sharp absorption lines attributed to U4+, and slightly elevated absorption towards shorter wavelengths. The ~1007 cm−1 ν3(SiO4) Raman band is broadened due to lattice distortion by non-stoichiometric elements in high-Th/-U zircon, whereas narrow bands in inclusion-rich domains indicate a decrease in lattice strain due to inclusion precipitation. Blue colouration in Vesuvius zircon is explained by the effect of light scattering (Rayleigh and/or Mie scattering) on highly refractive actinide-rich inclusions ranging in size from 〈1/10 to few multiples of the wavelengths of visible light. Inclusions likely formed during fluid-mediated coupled dissolution-reprecipitation that locally transformed lattice-strained actinide-rich zircon within several hundreds of years prior to eruption.
    Description: Published
    Description: 21–36
    Description: 1V. Storia eruttiva
    Description: 2V. Struttura e sistema di alimentazione dei vulcani
    Description: 3V. Proprietà chimico-fisiche dei magmi e dei prodotti vulcanici
    Description: 4V. Processi pre-eruttivi
    Description: 5V. Processi eruttivi e post-eruttivi
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 5
    Electronic Resource
    Electronic Resource
    Structural Optimization Design of MR Fluid Clutch (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 546-549 (May 2007), p. 1673-1676 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Magnetorheological (MR) fluids are suspensions of micron sized ferromagnetic particlesdispersed in varying proportions of a variety of non-ferromagnetic fluids. MR fluids exhibit rapid,reversible and significant changes in their rheological (mechanical) properties while subjected to anexternal magnetic field. In this paper, a double-plate magneto-rheological fluid (MRF) clutch withcontrollable torque output have been designed. Electromagnetic finite element analysis is used tooptimize the design of the clutch by using the commercial FEA software ANSYS
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/16/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.546-549.1673.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Positronium Chemistry in Polymeric Membrane Systems (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 607 (Nov. 2008), p. 1-8 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Positron and Positronium chemistry has been pursued and advanced by many scientists and engineers in both fundamental understanding of Positronium atom and its applications to chemical and polymeric systems during the last decade. This paper presents our recent results from collaborative investigations of positron annihilation in polymeric membranes. Future perspectives of applying Positronium chemistry to membrane science and technology and other related disciplines of nanotechnology, chemical engineering, materials science, energy research, molecules with positrons, biological and medical sciences appear to be promising
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/20/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.607.1.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    New flare stars and variable stars in the Sco-Oph region found in 1977
    Amsterdam : Elsevier
    Chinese Astronomy 4 (1980), S. 389-397 
    Details
    ISSN: 0146-6364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0146-6364(80)90031-6
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  • 8
    Electronic Resource
    Electronic Resource
    On the permissible region of motion in the general problem of three bodies
    Amsterdam : Elsevier
    Chinese Astronomy 3 (1979), S. 223-237 
    Details
    ISSN: 0146-6364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0146-6364(79)90013-6
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  • 9
    Electronic Resource
    Electronic Resource
    V879 Sco is a long-period variable
    Amsterdam : Elsevier
    Chinese Astronomy 4 (1980), S. 323 
    Details
    ISSN: 0146-6364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0146-6364(80)90018-3
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  • 10
    Electronic Resource
    Electronic Resource
    Genomic analysis of protein kinases, protein phosphatases and two-component regulatory systems of the cyanobacterium Anabaena sp. strain PCC 7120 (2002)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 217 (2002), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Anabaena sp. PCC 7120 is a cyanobacterium capable of performing several important biological functions: photosynthesis, nitrogen fixation, cell differentiation, cell–cell communication, etc. These activities require an extensive signaling capability in order to respond to the changing environment. Based on the genomic data, we have retrieved several gene families encoding signaling components. It is estimated that 211 genes encode two-component signaling elements, and 66 genes encode Ser/Thr kinases and phosphatases. These genes together represent 4.2% of the coding capacity of the whole genome, making Anabaena PCC 7120 a leading member among prokaryotes in terms of its signaling potential. It is known that two-component systems are composed of a few basic modules that can arrange into different structures best adapted for each signaling system. Many proteins in Anabaena PCC 7120 have incorporated both modules of two-component systems and catalytic domains of either Ser/Thr kinases or phosphatases. A family of 13 genes encode proteins with both a Ser/Thr kinase domain and a His kinase domain, and another four genes were also found whose products have both a response regulator domain and a Ser/Thr phosphatase domain. Of all the signaling proteins in Anabaena PCC 7120, about one third (35%) are conserved in the genome of the unicellular cyanobacterium strain Synechocystis sp. PCC 6803. Interestingly, one subfamily of His kinases and two subfamilies of response regulators are found in Anabaena PCC 7120 but are absent in Synechocystis PCC 6803. This study constitutes a basis for analyses of signal transduction in Anabaena PCC 7120 using functional genomic approaches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2002.tb11469.x
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