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  • 1
    Electronic Resource
    Electronic Resource
    Problems of UK universities (1990)
    [s.l.] : Nature Publishing Group
    Nature 348 (1990), S. 279-279 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-There is no doubt that British universities could and should do more to recover a greater fraction of overheads from external research contracts than the 14 per cent reported by Science and Engineering Policy Studies Unit (SEPSU) (Nature 347, 506; 1990). Something like the old University Grants ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/348279b0
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  • 2
    Electronic Resource
    Electronic Resource
    Keeping warm (1993)
    [s.l.] : Nature Publishing Group
    Nature 363 (1993), S. 108-108 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - August Reader (sic) suggests that DREADCO biochemists should turn their attention away from metabolic sti-mulants and consider ancient transcen-dental techniques for generating 'magical heat' as a means to prevent hypothermia (Nature 361, 200; 1993). Unfortunately, many of these trance-like ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/363108b0
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  • 3
    Electronic Resource
    Electronic Resource
    Leptin activation in hypothalamus (1996)
    [s.l.] : Nature Publishing Group
    Nature 381 (1996), S. 745-745 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - The excessive fat deposition and other genetic disorders seen in the obese ob/ob mouse has been shown to be due to a mutation (premature stop codon) in the ob gene1. Normally, the ob gene is expressed in adipose tissue, with the secreted circulating gene product, leptin, being thought to act ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/381745a0
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  • 4
    Electronic Resource
    Electronic Resource
    Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus (1981)
    [s.l.] : Nature Publishing Group
    Nature 289 (1981), S. 401-402 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] BAT thermogenesis can be monitored by recording the tissue temperature, as Flaim et al.2 did when stimulating the sympathetic nerves supplying interscapular BAT. This is the largest and most accessible BAT depot and recordings can be made with minimal surgery. We therefore used the same approach to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/289401a0
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  • 5
    Electronic Resource
    Electronic Resource
    A role for brown adipose tissue in diet-induced thermogenesis (1979)
    [s.l.] : Nature Publishing Group
    Nature 281 (1979), S. 31-35 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Measurement of energy balance during voluntary over-eating in rats unequivocally establishes the quantitative importance of diet-induced thermogenesis in energy balance. Like cold-induced thermogenesis, this form of heat production involves changes in the activity of the sympathetic nervous system ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/281031a0
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  • 6
    Electronic Resource
    Electronic Resource
    Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis (1980)
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 274-276 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the first experiments, the activity of mitochondrial enzymes and the effect of purine nucleotides on mitochondrial respiration were determined with brown adipose tissue of normal and cafeteria-fed animals. Groups of adult, male Sprague-Dawley rats (Charles River) were maintained on either the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/286274a0
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  • 7
    Electronic Resource
    Electronic Resource
    Reduced lipogenesis in cafeteria-fed rats exhibiting diet-induced thermogenesis (1983)
    Springer
    Bioscience reports 3 (1983), S. 217-224 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Fatty-acid synthesis has been measured in vivo with3H2O in cafeteria-fed rats exhibiting diet-induced thermogenesis. Synthesis was decreased in brown adipose tissue, the liver, white adipose tissue, and the carcass of the cafeteria-fed animals compared to rats fed the normal stock diet. Whole-body synthesis was also decreased in the cafeteria-fed group. Diet-induced thermogenesis, in contrast to cold-induced non-shivering thermogenesis does not lead to increased fatty-acid synthesis and this is presumably due to the inhibitory effects on lipogenesis of the high dietary fat intake characteristic of cafeteria diets. The results also indicate that the energy cost of body fat deposition in cafeteria-fed rats is lower than in animals fed a low-fat/high-carbohydrate stock diet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01122453
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  • 8
    Electronic Resource
    Electronic Resource
    Brown fat activity in fasted and refed rats (1984)
    Springer
    Bioscience reports 4 (1984), S. 351-357 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Four days of fasting in the rat reduced brown-adipose-tissue (BAT) mass, mitochondrial protein, and tissue protein content. Specific binding of guanosine diposphate (GDP) to BAT mitochondria was depressed by 55% in 4d-fasted rats. Rats fasted for 3 d, and then refed a single carbohydrate meal (40 kJ), showed a significant increase in specific GDP-binding (27% above fasted) 24 h later, and a large increase in total binding. Specific activities of cytochrome oxidase and α-glycerophosphate dehydrogenase in BAT mitochondria were not significantly affected by fasting or refeeding. These results suggest that BAT may be partly responsible for the fall in metabolic rate associated with fasting and the delayed increase after carbo-hydrate refeeding. These effects may be due to changes in the mitochondrial proton-conductance pathway in brown fat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01140499
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  • 9
    Electronic Resource
    Electronic Resource
    Mofification of body composition by clenbuterol in normal and dystrophic (mdx) mice (1985)
    Springer
    Bioscience reports 5 (1985), S. 755-760 
    Details
    ISSN: 1573-4935
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Female dystrophic mice (mdx on C57 Black background) gained weight more rapidly than age-matched controls and had a higher body fat content (% body weight), a slightly lower protein content and a reduced mass of muscle. Chronic treatment (21 d) of the mice with theβ 2-agonist clenbuterol stimulated weight gain in both genotypes without affecting energy intake. Clenbuterol increased the mass of the gastrocnemius and soleus muscle by 13% and 29% in normal and dystrophic mice, respectively, and raised body protein but depressed body fat. Body water and energy content were unaffected by clenbuterol, but the ratio of protein to fat in the carcasses was enhanced by 17% in normal and 56% in dystrophic mice following clenbuterol treatment. Thus, theβ 2-agonist restored the body composition of dystrophic mice to normal and enhanced the protein to fat ratio in both these and normal mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01119873
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  • 10
    Electronic Resource
    Electronic Resource
    Whither brown fat? (1986)
    Springer
    Bioscience reports 6 (1986), S. 3-18 
    Details
    ISSN: 1573-4935
    Keywords: brown adipose tissue ; thermogenesis ; cold ; diet ; neural control ; hormonal control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01145174
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