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  • 1
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 946-961 
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The three-dimensional structure of the extracellular region of a 60 kDa class II major histocompatibility glycoprotein, HLA-DR1, was determined to 3.3 Å by X-ray crystallography using three crystal forms, each containing two molecules per asymmetric unit. Phases were initially determined to 4.2 Å using two crystal forms both containing DR1 from human lymphocytes complexed with a mixture of endogenous peptides. One of these crystal forms also contained a 28 kDa superantigen, Staphylococcus aureus enterotoxin B (SEB), bound to each DR1 molecule. Single-isomorphous replacement phasing followed by iterative two- and fourfold non-crystallographic real-space averaging between the two crystal forms resulted in 4.2 Å resolution electron-density maps from which the paths of the polypeptides could be traced. Cryocrystallography and synchrotron radiation were then used to extend the resolution to 3.3 Å for the two lymphocyte-derived crystal forms and for a third crystal form grown from DR1 produced in insect cells and complexed in vitro with a specific antigenic peptide. Iterative sixfold non-crystallographic real-space averaging resulted in an electron- density map into which 340 of 371 residues could be fit unambiguously. Crystal contacts and the existence of a parallel dimer of the DR1 αβ heterodimer in the three crystal forms are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 2709-2716 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A simple gas collection apparatus based on the principles of a Torricelli tube has been designed and built to measure gas volume yields and flow rates. This instrument is routinely used to monitor and collect methane gas released during methane hydrate dissociation experiments. It is easily and inexpensively built, operates at ambient pressures and temperatures, and measures gas volumes of up to 7 L to a precision of about 15 ml (about 0.0025 mol). It is capable of measuring gas flow rates varying from more than 103 to less than 10−1 ml/min during gas evolution events that span minutes to several days. We have obtained a highly reproducible hydrate number of n=5.891 with a propagated uncertainty of ±0.020 for synthetic methane hydrate. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Experimental Cell Research 143 (1983), S. 247-255 
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Reviews of physiology, biochemistry and pharmacology 10 (1910), S. 531-597 
    ISSN: 1617-5786
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Reviews of physiology, biochemistry and pharmacology 12 (1912), S. 96-268 
    ISSN: 1617-5786
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 44 (1984), S. 497-508 
    ISSN: 1573-2878
    Keywords: Infinite-horizon optimal control problem ; overtaking optimality ; sporadic overtaking optimality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The present paper gives a systematic presentation of different definitions of optimality in the infinite-time optimal control problem. Some of these definitions are new, while others have been used throughout the literature, sometimes with different names. The logical implications between them are clearly stated, corresponding comparison criteria for solutions are defined, and other relations as well as two types of equivalence relations are established.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 15 (1987), S. 67-78 
    ISSN: 1573-9686
    Keywords: Holographic interferometry ; Double exposure ; Displacement ; Nondestructive testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Double-exposure holographic interferometry is a contactless whole-field method. Dimensional changes are visualized as a series of interference fringes overlaid on the holographic image of the femur, where each fringe represents 0.316 μm (half the wavelength of the laser light) of motion. Interferograms for intact femora and for femora with identical geometry prostheses were produced. We have shown that the femur bends as a beam under axial load. The position of maximum deflection is a function of the properties of the composite structure. Under a known load the amount of deflection can be calculated and the effect of the prosthesis's modulus can be ascertained. In addition to bending, rotational effects can be perceived. Although data interpretation is complex and holographic production is costly and time-consuming, the technique holds promise for biomechanical applications as well as other biomedical disciplines.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Scientometrics 3 (1981), S. 253-259 
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract This section ofScientometrics will carry fresh and reliable news of people, programs, recent and forthcoming meetings and publications etc. Its effectiveness depends greatly on your assistance. Items for inclusion should be submitted to the Coordinating Editor, Dr. J.Farkas.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 19 (1985), S. 563-575 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Porous coated surfaces for fixation of total hip replacement are a current trend in clinical orthopedics. Such devices are designed to be fixed by ingrowth of bony tissue, although in the absence of FDA approval for biologic fixation, fixation with PMMA cement is recommended by the implant manufacturers. In order to characterize the mechanical properties of the microinterlocked stem-cement interface, we tested both porous coated and smooth femoral components in cement mantles of consistent overall geometry. Under conditions of increasing load the smooth stems demonstrated stepwise irreversible subsidence into the mantle. Axial and circumferential strains measured in the cement containment vessels with the smooth stems showed that stepwise increases in tensile hoop strain occurred concomitantly with the stepwise incidents of stem subsidence. When subjected to the same loading conditions, the porous coated stems did not undergo stepwise incidents of subsidence, and hoop strain generation was reduced. In addition, a twofold increase in the failure load of the stem-cement interface was measured with the porous coated stems. Fatigue loading for 107 loading cycles did not result in gross failure of either the microinterlocked or smooth interfaces. However, the data showed that during fatigue loading, stepwise subsidence of the smooth stems again occurred. The final subsidence magnitude of the smooth stem-cement interface at 107 loading cycles was six times greater than the value associated with the porous coated stem. Thus the porous coating of femoral stems was shown to dramatically improve the load carrying capability and fatigue characteristics of the stem-cement interface.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2012-10-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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