Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract Five new 2,6-disubstituted derivatives of benzothiazole have been synthesized. The relation between the chemical structure and the biological activity of these compounds has been studied. It was found that the antimicrobial activity increases when sulfur in the number 2 position is oxidized to the sulfoxide and when the nitro group is introduced into the number 6 position in the corresponding sulfides. The preparations show no chemotherapeutic action in the animal body.
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