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  • 1
    ISSN: 0730-2312
    Keywords: DNA replication ; apoptosis ; DNA cleavage ; endonuclease ; Bal 31 ; topological domains ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: We have addressed the association between the site of DNA cleavage during apoptosis and DNA replication. DNA double strand breaks were introduced into chromatin containing pulse labeled nascent DNA by the induction of apoptosis or autocleavage of isolated nuclei. The location of these breaks in relation to nascent DNA were revealed by Bal 31 exonuclease digestion at the cut sites. Our data show that Bal31 accessible cut sites are directly linked to regions enriched in nascent DNA. We suggest that these regions coincide with the termini of replication domains, possibly linked by strong DNA-matrix interactions with biophysically defined topological structures of 0.5 - 1.3 Mbp in size. The 50 kbp fragments that are commonly observed as products of apoptosis are also enriched in nascent DNA within internal regions but not at their termini. It is proposed that these fragments contain a subset of replicon DNA that is excised during apoptosis through recognition of their weak attachment to the nuclear matrix within the replication domain.J. Cell. Biochem. 70:604-615, 1998. © 1998 Wiley-Liss, Inc. © 1998 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2017-07-19
    Description: At the present stage, oil is not just commodity but also a kind of asset, the value of which is associated with multiple financial processes. The impact of oil prices is particularly strong in the countries where trade in energy commodities has reached a high level in total exports. Russia belongs to such countries as well. Oil industry is one of the most important areas for supporting the economy development in Russia. Therefore, there is a need to develop measures for proper functioning of the oil industry, as it provides a significant share of Russia's GDP and budget revenues. Besides, about 80% of foreign investment goes directly to the oil and gas sector. In addition, the long-term dependence of the Russian economy on energy resources has led to decline in incentives for the development of other industries and creation of new technologies. The article explores the issues of dependence of the Russian economy on global oil prices and factors that influence the situation on the global oil market; the increasing role of the financial market of oil contracts in the context of the current economic development is substantiated. This article examines the situation when the country's export is largely focused on energy, while other industries significantly lag behind; it is described in the economic theory as a phenomenon dubbed "Dutch disease". This phenomenon is described by increase in extraction and export of commodities; besides, the influx of capital from exports stimulates consumer demand, but the industrial sector fails to keep up with the growth of the household income due to the pressure of the "Dutch disease", which ultimately increases inflation. In addition, this results in lagging of the processing sector of the economy behind the extractive sector. Keywords: oil market, World Trade Organization, reserve fund, economy JEL Classifications: O10, F10
    Electronic ISSN: 2146-4553
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
    Published by EconJournals
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