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  • 1
    Online Resource
    Online Resource
    Engineering of Microbial Biosynthetic Pathways (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Microbiology. ; Bioethics. ; Computer simulation. ; Biotechnology. ; Chemical Bioengineering. ; Microbiology. ; Bioethics. ; Computer Modelling.
    Description / Table of Contents: Chapter 1. Introduction to metabolic engineering -- Chapter 2. Microbial strain engineering -- Chapter 3. Techniques for detection and extraction of metabolites -- Chapter 4. Genetically encoded biosensors and their applications in the development of microbial cell factories -- Chapter 5. Metabolic products of mixed culture fermentation -- Chapter 6. Recent advances in genetic engineering tools for metabolic engineering -- Chapter 7. Recent developments in synthetic biology toolbox -- Chapter 8. Ethical, patent and regulatory issues in microbial engineering -- Chapter 9. Microbial production of Vitamins -- Chapter 10. Bacterial production of organic acids and subsequent metabolism -- Chapter 11. Microbial production of polysaccharides -- Chapter 12. Microbial Production of Industrial Proteins and Enzymes Using Metabolic Engineering -- Chapter 13. Microbial production of antibiotics using metabolic engineering -- Chapter 14. Metabolic Engineering Opening New Avenues for Therapeutics -- Chapter 15. Biofuels Production Using Metabolic Engineering -- Chapter 16. Microbial Utilization of Glycerol for Biomanufacturing -- Chapter 17. Revealing Function of Amino Acids in Nitrifying and Anammox Systems through Chromatography and Metagenomic Analyses.-.
    Abstract: This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.
    Type of Medium: Online Resource
    Pages: XV, 318 p. 42 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811526046
    URL: https://doi.org/10.1007/978-981-15-2604-6
    DOI: 10.1007/978-981-15-2604-6
    DDC: 660.6
    Language: English
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    E-BOOKS (AWI ONLY)
  • 2
    Unknown
    Biotechnology for Odor and Air Pollution Control (2005)
    Berlin, Heidelberg : Springer
    Details
    Keywords: Biochemical engineering ; Biotechnology ; Environmental protection ; Industrial engineering ; Microbiology
    ISBN: 9783540270072
    URL: https://doi.org/10.1007/b138434
    Language: English
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    E-BOOK
  • 3
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    Unknown
    Biogenic barium flux in the eastern equatorial Pacific Ocean (2020)
    PANGAEA
    Details
    Publication Date: 2023-02-08
    Description: We present the first regional-scale records of biogenic Barium (xsBa) fluxes in the Panama basin of the eastern-equatorial margin of the Pacific Ocean in order to assess xsBa as a paleoproductivity proxy. Measurements of xsBa from thirteen cores that range in water depths from about 700 ¬¬to 3000 m show an increase in 230Th normalized xsBa mass accumulation rates (MARs) with increasing water depth during both Marine Oxygen Isotope Stages (MIS) 1 and 2. The correlation of xsBa MARs with depth are strong despite differences in bulk sediment mass accumulation rates and differing degrees of sediment redistribution. We interpret the increasing xsBa with water depth as likely due to the continued decomposition and remineralization of falling and/or resuspended biogenic particles. xsBa does not seem to be affected by diagenetic sulfate reduction in most of the cores. Calculated estimates of xsBa preservation in the sediment pile are high and fluctuate between 45% - 52% throughout the last 25 kyr. Although xsBa fluxes can be a robust indicator of paleoproductivity, caution is needed if a) there is evidence of sulfate reduction in sediments being analyzed, and b) one is trying to quantify differences in paleoproductivity among sites that are located at different depths in the water column.
    Keywords: 230Th; AGE; Aluminium; authigenic Uranium (Uauth); Barite dissolution; Barium; Barium excess; Biogenic Barium (xsBa); DEPTH, sediment/rock; Eastern Equatorial Pacific Ocean; Event label; Latitude of event; Longitude of event; Melville; MUC; MultiCorer; MV1014; MV1014-01-1MC; MV1014-01-7MC; MV1014-02-16MC; MV1014-02-9MC; paleoproductivity; Panama Basin
    Type: Dataset
    Format: text/tab-separated-values, 124 data points
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    DATA PANGAEA
  • 4
    Electronic Resource
    Electronic Resource
    Effect of cypermethrin, mexacarbate, and phorate on phospholipid and lipid peroxidation in the snail Lymnaea acuminata (1993)
    Springer
    Bulletin of environmental contamination and toxicology 51 (1993), S. 68-71 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201002
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    General and kinetic properties of endoglucanase from Aspergillus niger (1990)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 71 (1990), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Endoglucanase of Aspergillus niger AS-101 was partially purified by ammonium sulphate fractionation and molecular sieving on Sephadex G-200. The enzyme was found to be unstable on storage, however, it received some protection on the addition of BSA, glycerol or sodium azide. Glycerol also protected the enzyme from inactivation due to freezing and thawing. Studies on the effect of thiol group reagents revealed the involvement of -SH group(s) at the active site of enzyme. The enzyme was a metallo-protein or it required certain metal ions for activation. A variety of modulators such as macroionic compounds and metal ions showed varying effects on the purified endoglucanase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1990.tb03826.x
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Production of protein and cellulase byAspergillus niger in solid state culture (1989)
    Springer
    World journal of microbiology and biotechnology 5 (1989), S. 451-456 
    Details
    ISSN: 1573-0972
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Résumé La production de protéine d'origine unicellulaire (POU) et de cellulase parAspergillus niger AS-101, cultivé sur des épis de maïs traités à l'alcali, est étudiée sous diverses conditions de culture. Les rendements maximum en POU et en cellulase par fermentation en milieu solide sont obtenus lorsque la culture est incubée à pH 5.5 pendant 18 jours à 30°C et avec une concentration en substrat de 12%.
    Notes: Summary Single-cell protein (SCP) and cellulase production byAspergillus niger AS-101, grown on alkalitreated corn cobs, was studied under various cultural conditions. The maximum yields of SCP and cellulase, under solid-state fermentation were obtained when the culture was incubated at pH 5.5 for 18 d at 30°C with 12% substrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741820
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of cypermethrin on lactate and succinic dehydrogenase and cytochrome oxidase of snail and fish (1993)
    Springer
    Bulletin of environmental contamination and toxicology 51 (1993), S. 445-452 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201765
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  • 8
    Electronic Resource
    Electronic Resource
    Properties of cellobiase from Aspergillus niger (1990)
    Springer
    Applied microbiology and biotechnology 34 (1990), S. 356-358 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Cellobiase enzyme was partially purified from the culture filtrate of Aspergillus niger AS-101 and the general and kinetic properties of the enzyme were examined. The enzyme was unstable on storage. However, it was protected by the addition of BSA, glycerol or sodium azide. Addition of glycerol also protected the enzyme from denaturation due to freezing and thawing. Effect of thiol group reagents revealed the presence of — SH groups at the active site of the enzyme. Different modulators such as metal ions and macroionic compounds illustrated varying effects on the purified cellobiase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170059
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  • 9
    Electronic Resource
    Electronic Resource
    Formation of acetic acid from cellulosic substrates byFusarium oxysporum (1991)
    Springer
    Applied microbiology and biotechnology 34 (1991), S. 570-572 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Four strains of Fusarium oxysporum and a strain of Monilia brunnae were screened for their ability to convert cellulosic substrates into ethanol/acetic acid. These strains were found to utilize cellulose and produce extracellular cellulases. However, only F. oxysporum 841 was found to convert glucose, xylose, and cellulose into ethanol and acetic acid as major end-products under microaerobic conditions. Acetic acid at a level of 4.7 g/l resulted in a single-step process on potato pulp medium, indicating the potential of the strain for converting cellulosic substrates into acetic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167900
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization by pulse-field electrophoresis of a new region of DNA amplification containing the M2 subunit of ribonucleotide reductase in hydroxyurea-resistant Leishmania (1999)
    Springer
    Parasitology research 85 (1999), S. 188-193 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An extrachromosomal circular DNA of approximately 50-kb size was amplified in the hydroxyurea-resistant variant of Leishmania mexicana amazonensis. The amplicon carried the M2 gene of ribonucleotide reductase as part of the gene encoding resistance to hydroxyurea. The amplicon was unstable. It disappeared rapidly as shown in pulse-field gradient electrophoresis gels after reversion of the cells for 20–80 days. This loss of amplified DNA was accompanied by a rapid loss of resistance to hydroxyurea during the same period. The amplicon was not hybridized to specific probes from any of the four regions of DNA amplification previously reported for Leishmania. This region of amplification thus appears to be a new region of DNA amplification in Leishmania.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004360050533
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