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  • 1
    Call number: PIK N 453-02-0108
    Type of Medium: Monograph available for loan
    Branch Library: PIK Library
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  • 2
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A computer-assisted method is introduced for the morphometric analysis of immunoreactive markers of the innervation of the heart, such as synaptophysin, neuropeptide Y (NPY), neurotensin (NT), substance P (SP), and calcitonin gene-related peptide (CGRP). Video images of stained sections were digitalized and the area density (AD) of the immunoreactive structures was measured by discrimination for grey levels within the myocardium of the right atrium, the perivascular region of epicardial arteries, and the trunk of the bundle of His. Synaptophysin immunoreactivity (IR), which served as a marker for presynaptic vesicles, indicated a dense innervation of the conductive system (AD 1.5241). Marked differences in the pattern of distribution were found between the neuropeptides. The AD of NPY-IR (0.5073) and SP-IR (0.1352) was highest in the perivascular tissue, while NT-IR (0.1628) and CGRP-IR (0.5161) exhibited maximal values in the bundle of His. The computer-assisted morphometric measurement of the AD of immunoreactive markers is suggested to be a suitable method for quantitative studies of the innervation of the heart under normal and experimental conditions.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experiments in fluids 12 (1991), S. 76-80 
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The purpose of this paper is to convey information and experience gained in the use of a rotating slanted hot-wire probe to measure the complete Reynolds stress tensor and the mean velocity vector. The technique is limited to nearly one-dimensional flows with turbulence intensities less than 10%. This paper extends the description of the method and discusses potential problems and difficulties one my encounter with this technique. In particular, the use of an appropriate least-squares technique (singular value decomposition) is suggested as this gives a more accurate fitting than simply using a matrix inversion of the normal equations. The covariance matrix is used to determine the slant angle and rotation positions of the probe most favorable to the least squares fitting and provides a measure of the uncertainties in the solution for the Reynolds stresses. The technique presented was used to determine the anisotropy of a turbulent flow with no mean shear. The results compare well with cross-wire measurements.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1420-9098
    Keywords: Trail pheromone ; Tapinoma simrothi ; pygidial glands ; iridodials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The pygidial (anal) gland was found to be the source of trail pheromone in the antTapinoma simrothi. Bioassays conducted with fractionated pygidial gland secretion indicated that the fraction containing iridodials and iridomyrmecin is responsible for the trail pheromone activity. Thus workers ofT. simrothi may utilize the same glandular exudate for alarm and trail following. At high emission rates from a point source, the ants responded in alarm, e.g., rushed to the source with open mandibles and raised abdomen. When concentrations were low and drawn as a line, the ants followed the secretion calmly. Trails ofT. simrothi are long-lived, having a biological half-life of 10 to 19 days. Quantitative studies of the evaporation rates of the iridodials by gas chromatography resulted in a half-life of 11 days, agreeing with the biological data. The implications of the use of the same glandular secretion for alarm and food recruitments are discussed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0827
    Keywords: Femoral neck ; Fracture ; Bone remodeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Hip fracture incidence has shown strong upward secular trends in many societies with wide differences in age adjusted incidence between nations. Falls and reduced physical activity have emerged as the strongest risk factors in epidemiological studies, while clinical investigations have pointed to secondary hyperparathyroidism as an important candidate cause of the loss of femoral cortical bone in old age. Until recently there have been few studies performed directly on the region of interest in the proximal femur. Noninvasive methodology using "Sr has now been developed by our group for measuring bone formation and (with concurrent serial DXA densitometry) resorption in the femoral neck. Bone turnover averaged about 8% annually in controls. A group of younger cases of femoral fracture showed similar indices of total and regional bone formation to a control group; but their resorption was higher. To further investigate this, a femoral neck bone biopsy technique has been developed which can be applied to fracture cases treated by arthroplasty. Preliminary studies have established that the anatomical asymmetry of the neck in cross-section is considerable and imposes restraints on the interpretation of smaller or incomplete femur biopsies. Prospects are quite good that, in the absence of tetracycline pre-labeling, mineralization can be studied by assessment of alkaline phosphatase-positive surfaces in cryostat sections. Moreover, such sections will permit study of other anatomically localized metabolic activities as well as antigen expression and osteocyte viability. Candidate mechanisms for the regional decline in bone quality as well as bone mass in subjects suffering hip fracture can now be investigated more effectively.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract An index of biotic integrity (IBI) was developed for the Little Arkansas River Basin (LARB) in south-central Kansas by establishing a reference condition for the watershed. Twelve metrics, in six categories, were chosen for use in the IBI. Fish assemblages from 30 sites were selected to represent the highest quality sites (reference sites) remaining in the LARB. In addition, 20 historical sites were used to show changes in the watershed over the last century. The modified IBI was then tested at 10 sites within the basin to assess the affects of urban and agricultural disturbances on fish community structure in the Wichita area. IBI scores were statistically lower for the urban versus the agricultural sites. Overall, IBI scores rated from poor to fair, supporting the contention that the fish communities within the LARB are impaired.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2018-08-10
    Description: We will report on two drilling proposals within the International Ocean Discovery Program (IODP) to address open questions on Antarctic Ice-sheet (AIS) dynamics in a transect from the Weddell Sea to the Scotia Sea on the Atlantic side of the Southern Ocean. IODP proposal 848-pre (Ice-sheet and sea-level history of the Weddell Sea) shall drill three contourite drifts northeast of Riiser-Larson Ice Shelf on the slope of the southeastern Weddell Sea that contain high-resolution Mio-Pleistocene sections. As the southern extension of the Atlantic Ocean, the Weddell Sea is a key area to study Earth‘s past climate variability. It constitutes a major source of Antarctic Bottom Water formation, which influences the Atlantic Meridional Overturning Circulation. Moreover, the Weddell Gyre is an important cyclonic circulation system for water-mass communication between the Antarctic Ice Sheet and the Southern Ocean. One of the world's two largest ice shelves, the Filchner-Rønne Ice Shelf, drains into the Weddell Basin. Ice-sheet dynamics in the Weddell Sea sector of the East Antarctic Ice Sheet (EAIS) are highly susceptible to far-field changes in sea level. Practically all icebergs from the EAIS merge in the Weddell Sea before they exit Antarctica through the Scotia Sea, thereby providing a unique location to study AIS dynamics. Despite these paramount scientific issues that have, over the last two decades, identified the Weddell Sea as a key area to study past and present climate change, there has been no deep scientific drilling for high-resolution reconstruction of the Plio-Pleistocene. Our scientific objectives aim at achieving the first complete Late Neogene reconstruction for the Weddell Sea. We will address the overarching questions on changing ice-sheet dynamics, interhemispheric phasing of ice-sheet and climate events, ocean circulation, and bottom-water production. Specifically, we wish to unravel whether the formation of the contourite ridges north of Crary Fan were associated with a sea-level drop initiated through intensification of Northern Hemisphere glaciation during the Pliocene. Also, did the drainage pattern change during the Mid-Pleistocene Transition? Can we decipher ice-sheet dynamics on glacial-to-interglacial time scales and during the Last Glacial Maximum? Can we detect farfield sea-level effects and rates of sea-level rise from Iceberg Alley? Can we relate varve thickness variations obtained from counting and dating varved sediment on the contourite ridges to external (solar) or internal (ocean-atmosphere) variability on decadal-to-centennial time scales? IODP proposal 847-full revised (Plio-Pleistocene reconstruction of ice-sheet, atmosphere, and ocean dynamics in Iceberg Alley) shall drill two deep-ocean sites in the Scotia Sea farther north. We aim at delivering the first well-dated, high-resolution and spatially integrated record of variability in icebergs flux from Iceberg Alley, where a substantial number of Antarctic icebergs exit from the Weddell Sea into the warmer Antarctic Circumpolar Current (ACC). In particular, we will characterize the iceberg flux during the mid-Pliocene warm interval, the mid-Pleistocene transition, the warm interglacials of the last 800 kyr, and during glacial terminations. We will use the geochemical provenance of detrital material to determine regional sources of AIS mass loss; address inter-hemispheric phasing of ice-sheet and climate events, and the relation of AIS variability to sea level. We will also deliver critical information on changes in Drake Passage throughflow, meridional overturning in the Southern Ocean, CO2 transfer via wind-induced upwelling, sea-ice variability, bottom water outflow from the Weddell Sea, Antarctic weathering inputs, and changes in oceanic and atmospheric fronts in the vicinity of the ACC by comparing north-south variations across the Scotia Sea. Comparing changes in dust proxy records between the Scotia Sea and Antarctic ice cores will provide a detailed reconstruction of changes in the Southern Hemisphere westerlies on millennial and orbital time scales for the last 800 kyr. Extending this comparison beyond 800 kyr will help evaluating climate-dust couplings since the Pliocene, its potential role in iron fertilization and atmospheric CO2 drawdown during glacials, and whether dust and changes in Antarctic ice volume played a role in the mid-Pleistocene transition.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , NonPeerReviewed
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  • 8
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Young, low-mass stars are luminous X-ray sources whose powerful X-ray flares may exert a profound influence over the process of planet formation. The origin of the X-ray emission is uncertain. Although many (or perhaps most) recently formed, low-mass stars emit X-rays as a consequence of ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 374 (1995), S. 601-602 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - In your recent editorial ("Nature Sister Publications", Nature 374, 95; 1995), there were several errors in the description of our paper reporting a mutation predisposing to type 1, or insulin-dependent diabetes mellitus (IDDM). Insulin-dependent diabetes mellitus is never abbreviated ...
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Mouse Chromosome (Chr) 7 distal to band F3 on the physical map is known to be subject to imprinting, maternal duplication (MatDp) of the region leading to a late embryonic lethality, while paternal duplication (PatDp) causes death in utero before 11.5 dpc. Using a new mouse reciprocal translocation T(7;11)65H to produce MatDp for distal Chr 7, we have mapped the region subject to imprinting more precisely to bands 7F4/F5 on the cytogenetic map. Fluorescence in situ hybridization (FISH) studies on mitotic and meiotic chromosomes of a T65H heterozygote show that the imprinted gene Igf2 is located in the same region. This was confirmed by the finding that embryos with MatDp of bands 7F4/F5 did not express Igf2. We suggest that other members of the imprinted domain containing Igf2, namely Mash2, H19, Ins2, and p57 K1P2 , are also located in 7F4/F5 and that some or all of these genes may be responsible for the two imprinting lethalities seen with MatDp and PatDp for this region.
    Type of Medium: Electronic Resource
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