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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of the zebrafish tbx16 gene and evolution of the vertebrate T-box family (1998)
    Springer
    Development genes and evolution 208 (1998), S. 94-99 
    Details
    ISSN: 1432-041X
    Keywords: Key words T-box ; Evolution ; Zebrafish ; Paraxial mesoderm ; Tail bud
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  We report on a new zebrafish T-box-containing gene, tbx16. It encodes a message that is first detected throughout the blastoderm soon after the initiation of zygotic gene expression. Following gastrulation, expression becomes restricted to paraxial mesoderm and later primarily to the developing tail bud. To gain an evolutionary prospective on the potential function of this gene, we have analyzed its phylogenetic relationships to known T-box genes from other species. Zebrafish tbx16 is likely orthologous to the chicken Tbx6L and Xenopus Xombi/Antipodean/Brat/VegT genes. Our analysis also shows that zebrafish tbx6 and mouse Tbx6 genes are paralogous to zebrafish tbx16. We present evidence which argues, that despite the same name and similar expression, zebrafish tbx6 and mouse Tbx6 genes are not orthologous to each other but instead represent relatively distant paralogs. The expression patterns of all genes are discussed in the light of their evolutionary relationships.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050158
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  • 2
    Electronic Resource
    Electronic Resource
    Reevaluation of the evidence for the generation of new lethal t haplotypes by mutation (1983)
    Springer
    Immunogenetics 18 (1983), S. 91-96 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401359
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  • 3
    Electronic Resource
    Electronic Resource
    An alpha globin pseudogene is located within the mouse t complex (1984)
    Springer
    Immunogenetics 19 (1984), S. 368-368 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345413
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  • 4
    Electronic Resource
    Electronic Resource
    A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties (1989)
    Springer
    Immunogenetics 30 (1989), S. 34-41 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have characterized a novel mouse gene (D17Si11) on chromosome 17 that expresses a major transcript observed uniquely in the testes. TheD17Si11 locus has been mapped to the central region of chromosome 17 betweenH-2 andC3. Sequence analysis demonstrates several unusual features of this locus and its transcript: first is the presence of complementary sets of alternating purine and pyrmidine residues within the 3′ region of the transcript that could form double-stranded, hairpin-like secondary structures with properties similar to that of Z-DNA; second is the existence of a hypothetical, long open reading frame in the nucleotide strand that is complementary to the testes transcripts. This complementary strand open reading frame is three times the size of the longest potential open reading frame present in the transcript itself. Although a function forD17Si11 has yet to be determined, the gene is relatively non-polymorphic in mice and appears conserved in mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02421467
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  • 5
    Electronic Resource
    Electronic Resource
    An alpha globin pseudogene is located within the mouse t complex (1984)
    Springer
    Immunogenetics 19 (1984), S. 125-130 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Restriction fragment length polymorphisms have been identified in the α-globin pseudogene carried on chromosome 17. Different inbred strains of mice carry one of two forms of the sequence, whereas all complete t haplotypes carry a third form. With the use of partial t haplotypes, the α-ψ44 sequence has been mapped to the distal end of the t complex. This sequence appears to be closely linked to the tufted locus in the t complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387855
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  • 6
    Electronic Resource
    Electronic Resource
    Production and characterization of antisera against three individual NHC proteins; a case of a generally distributed NHC protein (1978)
    Springer
    Chromosoma 68 (1978), S. 101-114 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In order to assess the selectivity of the distribution patterns of individual nonhistone chromosomal proteins (NHC proteins), immunofluorescent staining experiments were performed on Drosophila polytene chromosomes. Antisera have been prepared against three individual NHC proteins which were isolated by sequential preparative slab gel isoelectric focusing and SDS polyacrylamide gel electrophoresis. In two cases, immunofluorescent staining of the chromosomes indicated a specific limited distribution pattern; apparently the antigen in each case is present at a reproducible and distinct subset of chromomeres. This type of pattern has also been obtained with antisera prepared against molecular weight subfractions of NHC proteins (Silver and Elgin, 1977). Each selective fluorescence distribution pattern obtained so far is reproducible and unique to the antiserum under study. In a third case, an antiserum caused prominant staining at dense chromomeres and the chromocenter in a pattern mimicking DNA (and presumably histone) distribution. Indirect radioimmunostaining of SDS and isoelectric focusing gels on which total NHC proteins had been separated confirmed that this antiserum reacted specifically with a protein(s) of molecular weight 21,000 D and pI 5.2. The data in conjunction with absorption experiments indicates that the chromosomal staining is due to an interaction of antibodies with NHC protein(s) and not with histones. This finding suggests that at least one major acidic NHC protein plays a very general role (comparable to that of the histones) in maintaining chromatin structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00287143
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  • 7
    Electronic Resource
    Electronic Resource
    T-box gene tbx5 is essential for formation of the pectoral limb bud (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 417 (2002), S. 754-758 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The T-box genes Tbx4 and Tbx5 have been shown to have key functions in the specification of the identity of the vertebrate forelimb (Tbx5) and hindlimb (Tbx4). Here we show that in zebrafish, Tbx5 has an additional early function that precedes the formation of the limb bud itself. Functional ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature00814
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  • 8
    Electronic Resource
    Electronic Resource
    What are clones? (2001)
    [s.l.] : Nature Publishing Group
    Nature 412 (2001), S. 21-21 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] “Words that we expect to be generally used ... should be short, euphonious, phonetically spelled, easily pronounced and different from any other word in ordinary use so that it [sic] will not suggest any other meaning than the one desired.” With this explanation, Herbert J. Webber ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35083650
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  • 9
    Electronic Resource
    Electronic Resource
    Bioethicists must come down to Earth (1999)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 399 (1999), S. 728-728 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SirYou report, without critique, the opinion of Canadian bioethicist Margaret Somerville that “science will need to wait and to help ethics to catch up” (Nature 399, 12; 1999). Any regular reader of your journal is sure ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/21518
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  • 10
    Electronic Resource
    Electronic Resource
    Bouncing off microsatellites (1992)
    [s.l.] : Nature Publishing Group
    Nature genetics 2 (1992), S. 8-9 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Since the publication of Garrod's Inborn Errors of Metabolism in 19091, there has been an ever-increasing recognition that heredity can play at least a facilitating role in most, if not all, non-infectious diseases that affect human beings. Nevertheless, for the greater part of the twentieth ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0992-8
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