Keywords:
Clinical medicine Research.
;
Medicine Research.
;
Biology Research.
;
Drug delivery systems.
;
Medical Ethics.
;
Clinical Research.
;
Biomedical Research.
;
Drug Delivery.
;
Medical Ethics.
Description / Table of Contents:
Chapter 1. The Roadmap to Research: Fundamentals of a Multifaceted Research Process -- Chapter 2. Processes involved in the generation of novel ideas -- Chapter 3. Creativity and critical thinking contribute to scholarly achievement -- Chapter 4. Writing protocols in Pharmacological studies -- Chapter 5. Basics of Designing General Toxicology Studies -- Chapter 6. General design considerations in Reproductive and developmental toxicity studies -- Chapter 7. Genetic toxicology studies -- Chapter 8. Rodent Carcinogenicity Studies.-Chapter 9. Designing studies in pharmaceutical and medicinal chemistry -- Chapter 10. Experimental protocols in phytochemistry and natural products: an ever-evolving challenge -- Chapter 11. Drug substance/ product quality analysis (Quality assessment) -- Chapter 12. Drug Delivery Systems: Lipid Nanoparticles Technology in Clinic -- Chapter 13. Pharmacokinetic studies for drug development -- Chapter 14. New Alternative Methods in drug safety assessment -- Chapter 15. Animal models for the study of human disease -- Chapter 16. Physiologically based Pharmacokinetic Modelling in Drug Discovery and Clinical Development: A Treatise on Concepts, Model Workflow, Credibility, Application and Regulatory Landscape -- Chapter 17. Design and conduct of pharmacokinetics studies influenced by extrinsic factors -- Chapter 18. Specific Populations: Clinical Pharmacology Considerations -- Chapter 19. Impact of genetic variation on drug response.-Chapter 20. Phases of clinical trials -- Chapter 21. Common clinical trial designs -- Chapter 22. Elements of clinical trial protocol design -- Chapter 23. Good clinical practice in clinical trials, substantial evidence of efficacy, and interpretation of the evidence -- chapter 24. Grandfathered Drugs of 1938 in the United States -- Chapter 25. General overview of the statistical issues in clinical study designs -- Chapter 26. Introduction to pharmacoepidemiology and its application in clinical research -- Chapter 27. Pharmacovigilance through phased clinical trials, post-marketing surveillance and ongoing life cycle safety -- Chapter 28. The design and statistical analysis of randomized pre-clinical experiments -- Chapter 29. Descriptive and Inferential Statistics in Biomedical Sciences: an overview -- Chapter 30. Principles and applications of statistics in biomedical research: parametric and non-parametric tests including tests employed for Post-hoc analysis -- Chapter 31. Artificial intelligence generative chemistry design of target-specific scaffold-focused small molecule drug libraries -- Chapter 32. Artificial intelligence technologies for clinical data pharmacoanalytics. Case studies on Alzheimer’s disease -- Chapter 33. Bioinformatics: Theory and Application -- Chapter 34. Drug targets and drug discovery research -- Chapter 35. Role of Nonclinical Programs in Drug Development -- Chapter 36. Drug repurposing: strategies and study design in bringing back old drugs to the mainline -- Chapter 37. Empowering knowledge on efficient literature search: an overview of biomedical search engines and databases -- Chapter 38. Literature Reviews: An Overview of Systematic, Integrated, and Scoping Review -- Chapter 39. How To Create A Bibliography -- Chapter 40. Publication metrics /Bibliometrics -- Chapter 41. How to write a scientific paper -- Chapter 42. Preparing and structuring a manuscript for publication -- Chapter 43. Writing a scientific article -- Chapter 44. How to Present Results in a Research Paper -- Chapter 45. Communicating results of quantitative research -- Chapter 46. How to Efficiently Write a Persuasive Discussion Section -- Chapter 47. Submitting a manuscript for publication, the peer review process, and getting past the gatekeepers -- Chapter 48. Writing a Postgraduate or Doctoral Thesis: A Step-by-Step Approach -- Chapter 49. Poster presentation at scientific meetings -- Chapter 50. Strategies for the preparation and delivery of oral presentation -- Chapter.-51. Grant Process and Peer Review ─ US National Institutes of Health System -- Chapter 52. Rigor and specifics in writing research proposal -- Chapter 53. Writing research grant proposals ─ from an Indian Perspective -- Chapter 54. Funding opportunities (resources) in biomedical sciences: Indian perspective -- Chapter 55. Mentorship in biomedical sciences -- chapter 56. Commercializing the technology – transitioning from the academic lab to the market -- Chapter 57. Patent law fundamentals for biomedical scientists -- Chapter 58. Research integrity: responsible conduct of research -- Chapter 59. Publication integrity, authorship, and misconduct.
Abstract:
The book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clinical trial design to acquire substantial evidence of efficacy and safety for candidate drugs in the target patient population. New and evolving topics such as artificial intelligence, machine and deep learning, drug repurposing approaches, and bioinformatics, are incorporated into the text as these features are becoming integrated into drug research and development. Additionally, it covers publication strategies, including literature search, manuscript preparation, data presentation, relevant discussion, editorial processes, elements of peer review, and bibliometrics. Finally, the book addresses grantsmanship, key strategies for building effective networks, mentorships, maintaining research integrity, and forging career advancement opportunities, including entrepreneurship.
Type of Medium:
Online Resource
Pages:
XXII, 941 p. 1 illus.
,
online resource.
Edition:
1st ed. 2023.
ISBN:
9789819912841
URL:
https://doi.org/10.1007/978-981-99-1284-1
DOI:
10.1007/978-981-99-1284-1
DDC:
615.50724
Language:
English
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