Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Starting with 1,1,1-trifluoroacetone, 3-(trifluoromethyl)-1-(trimethylsilyloxy)-1,3-butadiene (2) has been prepared as a mixture of (Z) and (E) isomers. The diene undergoes [4 + 2] cycloaddition reactions with a variety of dienophiles affording trifluoromethyl-substituted carbocyclic and heterocyclic compounds 7-11 in yields ranging from moderate to good.
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