ISSN:
1573-6881
Keywords:
Import receptor
;
mitochondria
;
Tom complex
;
translocation
;
preprotein recognition
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract Most proteins involved in mitochondrial biogenesis are encoded by the genome of the nucleus.They are synthesized in the cytosol and have to be transported toward and, subsequently,imported into the organelle. This targeting and import process is initiated by the specificmitochondrial targeting signal, which differs pending on the final localization of the protein.The preprotein will be recognized by cytosolic proteins, which function in transport towardthe mitochondria and in maintaining the import competent state of the preprotein. The precursorwill be transferred onto a multicomponent complex on the outer mitochondrial membrane,formed by receptor proteins and the general insertion pore (GIP). Some proteins are directlysorted into the outer membrane whereas the majority will be transported over the outermembrane through the import channel followed by further distribution of those proteins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005512412404
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