ISSN:
1573-4919
Keywords:
signal transduction
;
T. cruzi growth control
;
phospholipid metabolism
;
inositol phosphates
;
diacylglycerol-phospholipase C
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Fetal calf serum (FCS), which is mitogenic for the pathogenic protozoaT. cruzi, inhibits cAMP production in basal and forskolin-stimulated epimastigotes. It also activates phosphoinositides hydrolysis yielding diacylglycerol and inositol phosphates (Ins-P). Ins-P production is enhanced by AlF4-, GTP or β-γ-methylene-GTP, thus implying G proteins mediation in the phenomenon. An enzyme with phospholipase C activity which may be involved in the phospholipid metabolism was partially characterized.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00929200
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