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  • 1
    ISSN: 1617-4623
    Keywords: Antibiotics ; Archaebacteria ; Ribosomes ; Evolution ; Thermoplasma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The susceptibility of Thermoplasma acidophilum (an extremely acidophilic, moderately thermophilic, wall-less sulphur-oxidizing archaebacterium) to 50 ribosome-specific inhibitors of polypeptide elongation was surveyed using efficient poly(U)-and poly(UG)-directed cell-free systems and comparable reference systems derived from eubacterial (Bacillus stearothermophilus, Escherichia coli) and eukaryotic (Saccharomyces cerevisiae) species. Under optimum temperature (58° C) and ionic conditions for polypeptide synthesis Thermoplasma ribosomes are only sensitive to the 70 S/80 S ribosome-directed aminoglycoside neomycin, and to five 80 S ribosome-directed inhibitors all of which (α-sarcin, mitogillin, restrictocin, dianthin and gelonin) impair the functioning of the large (60 S) ribosomal subunit. Sensitivity of the three structurally related compounds α-sarcin, mitogillin and restrictocin and susceptibility to neomycin place Thermoplasma ribosomes between those of Sulfolobus solfataricus (only sensitive to α-sarcin) and Methanococcus vannielli (sensitive to α-sarcin, mitogillin, restrictocin and neomycin but also affected by a variety of 70 S ribosome-directed drugs). The phylogenetic significance of the greatly diversified antibiotic sensitivity spectra displayed by archaebacteria in general, as opposed to the uniform ones exhibited by eubacteria and eukaryotes, is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1617-4623
    Keywords: Archaebacteria ; Protein synthesis ; Ribosomes ; Mistranslation ; Antibiotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The effect of selected aminoglycoside antibiotics on the translational accuracy of poly(U) programmed ribosomes derived from the thermophilic archaebacteria Thermoplasma acidophilum, Sulfolobus solfataricus, Thermococcus celer and Desulfurococcus mobilis has been determined. Under optimum temperature and ionic conditions for polyphenylalanine synthesis, the four species investigated are found to be markedly diverse in their response to the miscoding-inducing action of aminoglycoside antibiotics. T. acidophilum is sensitive to all of the compounds tested except streptomycin; S. solfataricus responds to paromomycin and to hygromycin B; T. celer is only affected by neomycin, and D. mobilis is refractory to all drugs. The only feature shared by the four species under study, and by all archaebacteria so far investigated, is their complete insensitivity to streptomycin. The structural and phylogenetic implications of the remarkable diversity encountered among archaebacterial ribosomes in their susceptibility to aminoglycosides are discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The Las Hoyas fossil site is one of the most important conservative lagerstatten from the Lower Cretaceous of western Europe. It has yielded thousands of specimens including two of the most primitive birds ever found: Iberomesornis romerali1'2 and Con-cornis lacustris3. A diversified flora and ...
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have discovered a mass of fossil bones from four juvenile birds at Las Hoyas in Cuenca, Spain, which show signs of having been digested. To our knowledge, this rare finding of an Early Cretaceous fossil of an apparently regurgitated pellet provides the first evidence that Mesozoic birds were ...
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fossil birds for the Early Cretaceous of Las Hoyas are among the most informative for understanding the early evolutionary history of birds. Two avian taxa have been described to date: the basal ornithothoracine Iberomesomis12 and the enantiornithine Concomis3'4. A new and well-preserved bird ...
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2013-08-31
    Description: A set of sample cases was produced to test an automated design procedure developed at the NASA Lewis Research Center for the design of controlled diffusion blades. The range of application of the automated design procedure is documented. The results presented include characteristic compressor and turbine blade sections produced with the automated design code as well as various other airfoils produced with the base design method prior to the incorporation of the automated procedure.
    Keywords: AIRCRAFT PROPULSION AND POWER
    Type: E-4665 , NASA-TM-101968 , NAS 1.15:101968
    Format: application/pdf
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  • 8
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2013-08-31
    Description: The method of complex characteristics and hodograph transformation for the design of shockless airfoils was introduced by Bauer, Garabedian, and Korn and has been extended by the author to design subcritical and supercritical cascades with high solidities and large inlet angles. This new capability was achieved by introducing a new conformal mapping of the hodograph domain onto an ellipse and expanding the solution in terms of Chebyshev polynomials. A new computer code, the NASA Lewis inverse design code, was developed based on this idea. This new design code is an efficient method for the design of airfoils in cascade. In particular, the design of subcritical cascades of airfoils is a very fast, robust, and versatile process. The inverse design code can be made to interact with a turbulent boundary layer calculation to obtain airfoils with no separated flows at the design condition. This report is intended to serve as a users manual for this design code. Material previously reported by the author is included here for completeness and quick access to the user. The manual contains a description of the method followed by a discussion of the design procedure and examples. The input parameters necessary to run the code are then described and their default values given. Output listings corresponding to six different blade shapes designed with the code are given, as well as the necessary input data to reproduce the computer runs. The examples have been chosen to show that a wide range of applications can be covered with the code, ranging from supercritical propeller sections to wind tunnel turning vanes that can operate with a large inlet flow angle range.
    Keywords: AERODYNAMICS
    Type: NAS 1.60:2676 , NASA-TP-2676 , E-3221
    Format: application/pdf
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  • 9
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2013-08-31
    Description: A numerical automation procedure has been developed to be used in conjunction with an inverse hodograph method for the design of controlled diffusion blades. With this procedure a cascade of airfoils with a prescribed solidity, inlet Mach number, inlet air flow angle, and air flow turning can be produced automatically. The trailing edge thickness of the airfoil, an important quantity in inverse methods, is also prescribed. The automation procedure consists of a multidimensional Newton iteration in which the objective design conditions are achieved by acting on the hodograph input parameters of the underlying inverse code. The method, although more general in scope, is applied in this paper to the design of axial flow compressor blade sections, and a wide range of examples is presented.
    Keywords: AERODYNAMICS
    Type: E-3877 , NAS 1.15:100251 , NASA-TM-100251
    Format: application/pdf
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  • 10
    facet.materialart.
    Unknown
    In:  CASI
    Publication Date: 2013-08-31
    Description: A numerical automation procedure was developed to be used in conjunction with an inverse hodograph method for the design of controlled diffusion blades. With this procedure a cascade of airfoils with a prescribed solidity, inlet Mach No., inlet air flow angle and air flow turning can be produced automatically. The trailing edge thickness of the airfoil, an important quantity in inverse methods, is also prescribed. The automation procedure consists of a multi-dimensional Newton iteration in which the objective design conditions are achieved by acting on the hodograph input parameters of the underlying inverse code. The method, although more general in scope, is applied to the design of axial flow turbomachinery blade sections, both compressors and turbines. A collaborative effort with U.S. Engine Companies to identify designs of interest to the industry will be described.
    Keywords: AERODYNAMICS
    Type: NASA, Ames Research Center, NASA Computational Fluid Dynamics Conference. Volume 2: Sessions 7-12; p 231-244
    Format: application/pdf
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