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  • 1
    Electronic Resource
    Electronic Resource
    Erratum Diagonal Polynomials and Diagonal Orders on Multidimensional Lattices (2000)
    Springer
    Theory of computing systems 33 (2000), S. 107-107 
    Details
    ISSN: 1433-0490
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract. No abstract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002249910007
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  • 2
    Electronic Resource
    Electronic Resource
    Diagonal polynomials for small dimensions (1996)
    Springer
    Theory of computing systems 29 (1996), S. 305-310 
    Details
    ISSN: 1433-0490
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract HereR andN denote respectively the real numbers and the nonnegative integers. Also 0 〈n εN, ands(x) =x 1+...+x n when x = (x 1,...,x n) εR n. Adiagonal function of dimensionn is a mapf onN n (or any larger set) that takesN n bijectively ontoN and, for all x, y inN n, hasf(x) 〈f(y) whenevers(x) 〈s(y). We show that diagonalpolynomials f of dimensionn all have total degreen and have the same terms of that degree, so that the lower-degree terms characterize any suchf. We call two polynomialsequivalent if relabeling variables makes them identical. Then, up to equivalence, dimension two admits just one diagonal polynomial, and dimension three admits just two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01201282
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  • 3
    Electronic Resource
    Electronic Resource
    On Tournaments Free of Large Transitive Subtournaments (1998)
    Springer
    Graphs and combinatorics 14 (1998), S. 181-200 
    Details
    ISSN: 1435-5914
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract.  Erdös and Moser posed the problem of determining, for each integer n〉0, the greatest integer v(n) such that all tournaments of order n contain the transitive subtournament of order v(n) (denoted TT v(n)). It is known that v(n)=3 for , v(n)=4 for , v(n)=5 for , and for n〉27. Moreover, the uniqueness of the tournaments free of TT 4 of orders 6 and 7, and free of TT 5 and TT 6 of orders 13 and 27, respectively, has been established. Here we prove that the tournaments of orders 12 and 26, free of TT 5 and TT 6, respectively, are also unique. Then, we see that all tournaments of order 54 contain TT 7 (improving the best lower bound known for v(n)). Finally, with the aid of a computer, we obtain the orders cv(r) and gv(s) of the biggest transitive tournaments contained, respectively, in all circulant tournaments of order r≤55 and in each Galois tournament of order s〈1000, i.e., in the tournament with set of vertices the Galois field of order s (whenever it exists) and edge directions induced by the quadratic residues. We get better upper bounds of v(n), for n≤991.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003730050025
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  • 4
    Electronic Resource
    Electronic Resource
    A family of (n−1)! Diagonal polynomial orders ofN n (1995)
    Springer
    Order 12 (1995), S. 173-187 
    Details
    ISSN: 1572-9273
    Keywords: 06A06 ; 68R05 ; Polynomial orders ; diagonal orders ; packing functions ; storing functions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Letn〉0 be an element of the setN of nonnegative integers, and lets(x)=x 1+...+x n , forx=(x 1, ...,x n ) ∈N n . Adiagonal polynomial order inN n is a bijective polynomialp:N n ↦N (with real coefficients) such that, for allx,y ∈N n ,p(x)〈p(y) whenevers(x)〈s(y). Two diagonal polynomial orders areequivalent if a relabeling of variables makes them identical. For eachn, Skolem (1937) found a diagonal polynomial order. Later, Morales and Lew (1992) generalized this polynomial order, obtaining a family of 2 n−2 (n〉1) inequivalent diagonal polynomial orders. Here we present, for eachn〉0, a family of (n − 1)! diagonal polynomial orders, up to equivalence, which contains the Morales and Lew diagonal orders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01108626
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  • 5
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    Novel transcriptome assembly and improved annotation of the whiteleg shrimp (Litopenaeus vannamei), a dominant crustacean in global seafood mariculture (2014)
    Springer Nature
    Details
    Publication Date: 2014-11-26
    Description: We present a new transcriptome assembly of the Pacific whiteleg shrimp (Litopenaeus vannamei), the species most farmed for human consumption. Its functional annotation, a substantial improvement over previous ones, is provided freely. RNA-Seq with Illumina HiSeq technology was used to analyze samples extracted from shrimp abdominal muscle, hepatopancreas, gills and pleopods. We used the Trinity and Trinotate software suites for transcriptome assembly and annotation, respectively. The quality of this assembly and the affiliated targeted homology searches greatly enrich the curated transcripts currently available in public databases for this species. Comparison with the model arthropod Daphnia allows some insights into defining characteristics of decapod crustaceans. This large-scale gene discovery gives the broadest depth yet to the annotated transcriptome of this important species and should be of value to ongoing genomics and immunogenetic resistance studies in this shrimp of paramount global economic importance. Scientific Reports 4 doi: 10.1038/srep07081
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 6
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    Morphological changes produced by acid dissolution in Er:YAG laser irradiated dental enamel (2014)
    Wiley
    Details
    Publication Date: 2014-03-25
    Description: ABSTRACT Several scientific reports have shown the effects of Er:YAG laser irradiation on enamel morphology. However, there is lack of information regarding the morphological alterations produced by the acid attack on the irradiated surfaces. The aim of this study was to evaluate the morphological changes produced by acid dissolution in Er:YAG laser irradiated dental enamel. Forty-eight enamel samples were divided into four groups ( n  = 12). GI (control); Groups II, III, and IV were irradiated with Er:YAG at 100 mJ (12.7 J/cm 2 ), 200 mJ (25.5 J/cm 2 ), and 300 mJ (38.2 J/cm 2 ), respectively, at 10 Hz without water irrigation. Enamel morphology was evaluated before-irradiation, after-irradiation, and after-acid dissolution, by scanning electron microscopy (SEM). Sample coating was avoided and SEM analysis was performed in a low-vacuum mode. To facilitate the location of the assessment area, a reference point was marked. Morphological changes produced by acid dissolution of irradiated enamel were observed, specifically on laser-induced undesired effects. These morphological changes were from mild to severe, depending on the presence of after-irradiation undesired effects. Microsc. Res. Tech., 2014 . © 2014 Wiley Periodicals, Inc.
    Print ISSN: 1059-910X
    Electronic ISSN: 1097-0029
    Topics: Natural Sciences in General
    Published by Wiley
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  • 7
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    Analysis of sequencing strategies and tools for taxonomic annotation: Defining standards for progressive metagenomics (2018)
    Springer Nature
    Details
    Publication Date: 2018-08-14
    Description: Analysis of sequencing strategies and tools for taxonomic annotation: Defining standards for progressive metagenomics Analysis of sequencing strategies and tools for taxonomic annotation: Defining standards for progressive metagenomics, Published online: 13 August 2018; doi:10.1038/s41598-018-30515-5 Analysis of sequencing strategies and tools for taxonomic annotation: Defining standards for progressive metagenomics
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 8
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    The genomes of four tapeworm species reveal adaptations to parasitism (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-03-15
    Description: Tapeworms (Cestoda) cause neglected diseases that can be fatal and are difficult to treat, owing to inefficient drugs. Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples. The 115- to 141-megabase genomes offer insights into the evolution of parasitism. Synteny is maintained with distantly related blood flukes but we find extreme losses of genes and pathways that are ubiquitous in other animals, including 34 homeobox families and several determinants of stem cell fate. Tapeworms have specialized detoxification pathways, metabolism that is finely tuned to rely on nutrients scavenged from their hosts, and species-specific expansions of non-canonical heat shock proteins and families of known antigens. We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964345/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964345/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tsai, Isheng J -- Zarowiecki, Magdalena -- Holroyd, Nancy -- Garciarrubio, Alejandro -- Sanchez-Flores, Alejandro -- Brooks, Karen L -- Tracey, Alan -- Bobes, Raul J -- Fragoso, Gladis -- Sciutto, Edda -- Aslett, Martin -- Beasley, Helen -- Bennett, Hayley M -- Cai, Jianping -- Camicia, Federico -- Clark, Richard -- Cucher, Marcela -- De Silva, Nishadi -- Day, Tim A -- Deplazes, Peter -- Estrada, Karel -- Fernandez, Cecilia -- Holland, Peter W H -- Hou, Junling -- Hu, Songnian -- Huckvale, Thomas -- Hung, Stacy S -- Kamenetzky, Laura -- Keane, Jacqueline A -- Kiss, Ferenc -- Koziol, Uriel -- Lambert, Olivia -- Liu, Kan -- Luo, Xuenong -- Luo, Yingfeng -- Macchiaroli, Natalia -- Nichol, Sarah -- Paps, Jordi -- Parkinson, John -- Pouchkina-Stantcheva, Natasha -- Riddiford, Nick -- Rosenzvit, Mara -- Salinas, Gustavo -- Wasmuth, James D -- Zamanian, Mostafa -- Zheng, Yadong -- Taenia solium Genome Consortium -- Cai, Xuepeng -- Soberon, Xavier -- Olson, Peter D -- Laclette, Juan P -- Brehm, Klaus -- Berriman, Matthew -- 085775/Wellcome Trust/United Kingdom -- 098051/Wellcome Trust/United Kingdom -- BBG0038151/Biotechnology and Biological Sciences Research Council/United Kingdom -- MOP#84556/Canadian Institutes of Health Research/Canada -- TW008588/TW/FIC NIH HHS/ -- England -- Nature. 2013 Apr 4;496(7443):57-63. doi: 10.1038/nature12031. Epub 2013 Mar 13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23485966" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological/*genetics ; Animals ; Biological Evolution ; Cestoda/drug effects/*genetics/physiology ; Cestode Infections/drug therapy/metabolism ; Conserved Sequence/genetics ; Echinococcus granulosus/genetics ; Echinococcus multilocularis/drug effects/genetics/metabolism ; Genes, Helminth/genetics ; Genes, Homeobox/genetics ; Genome, Helminth/*genetics ; HSP70 Heat-Shock Proteins/genetics ; Humans ; Hymenolepis/genetics ; Metabolic Networks and Pathways/genetics ; Molecular Targeted Therapy ; Parasites/drug effects/*genetics/physiology ; Proteome/genetics ; Stem Cells/cytology/metabolism ; Taenia solium/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 9
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    High-throughput decoding of antitrypanosomal drug efficacy and resistance (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-01-27
    Description: The concept of disease-specific chemotherapy was developed a century ago. Dyes and arsenical compounds that displayed selectivity against trypanosomes were central to this work, and the drugs that emerged remain in use for treating human African trypanosomiasis (HAT). The importance of understanding the mechanisms underlying selective drug action and resistance for the development of improved HAT therapies has been recognized, but these mechanisms have remained largely unknown. Here we use all five current HAT drugs for genome-scale RNA interference target sequencing (RIT-seq) screens in Trypanosoma brucei, revealing the transporters, organelles, enzymes and metabolic pathways that function to facilitate antitrypanosomal drug action. RIT-seq profiling identifies both known drug importers and the only known pro-drug activator, and links more than fifty additional genes to drug action. A bloodstream stage-specific invariant surface glycoprotein (ISG75) family mediates suramin uptake, and the AP1 adaptin complex, lysosomal proteases and major lysosomal transmembrane protein, as well as spermidine and N-acetylglucosamine biosynthesis, all contribute to suramin action. Further screens link ubiquinone availability to nitro-drug action, plasma membrane P-type H(+)-ATPases to pentamidine action, and trypanothione and several putative kinases to melarsoprol action. We also demonstrate a major role for aquaglyceroporins in pentamidine and melarsoprol cross-resistance. These advances in our understanding of mechanisms of antitrypanosomal drug efficacy and resistance will aid the rational design of new therapies and help to combat drug resistance, and provide unprecedented molecular insight into the mode of action of antitrypanosomal drugs.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303116/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303116/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alsford, Sam -- Eckert, Sabine -- Baker, Nicola -- Glover, Lucy -- Sanchez-Flores, Alejandro -- Leung, Ka Fai -- Turner, Daniel J -- Field, Mark C -- Berriman, Matthew -- Horn, David -- 085775/Wellcome Trust/United Kingdom -- 085775/Z/08/Z/Wellcome Trust/United Kingdom -- 090007/Wellcome Trust/United Kingdom -- 090007/Z/09/Z/Wellcome Trust/United Kingdom -- 093010/Wellcome Trust/United Kingdom -- 093010/Z/10/Z/Wellcome Trust/United Kingdom -- England -- Nature. 2012 Jan 25;482(7384):232-6. doi: 10.1038/nature10771.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22278056" target="_blank"〉PubMed〈/a〉
    Keywords: Aquaglyceroporins/deficiency/metabolism ; Drug Resistance/*genetics ; Eflornithine/pharmacology ; Endocytosis/drug effects ; Glycosylation/drug effects ; High-Throughput Screening Assays ; Humans ; Lysosomes/drug effects/metabolism ; Melarsoprol/pharmacology ; Nifurtimox/pharmacology ; Pentamidine/pharmacology ; RNA Interference ; Suramin/pharmacology ; Trypanocidal Agents/*pharmacology/therapeutic use ; Trypanosoma brucei brucei/cytology/*drug effects/enzymology/metabolism ; Trypanosomiasis, African/*drug therapy/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 10
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    Genomic and functional characterisation of two Enterococcus strains isolated from Cotija cheese and their potential role in ripening (2018)
    Springer
    Details
    Publication Date: 2018-01-25
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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