Publication Date:
2005-02-01
Description:
Brassinosteroid (BR) homeostasis and signaling are crucial for normal growth and development of plants. BR signaling through cell-surface receptor kinases and intracellular components leads to dephosphorylation and accumulation of the nuclear protein BZR1. How BR signaling regulates gene expression, however, remains unknown. Here we show that BZR1 is a transcriptional repressor that has a previously unknown DNA binding domain and binds directly to the promoters of feedback-regulated BR biosynthetic genes. Microarray analyses identified additional potential targets of BZR1 and illustrated, together with physiological studies, that BZR1 coordinates BR homeostasis and signaling by playing dual roles in regulating BR biosynthesis and downstream growth responses.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925132/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925132/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉He, Jun-Xian -- Gendron, Joshua M -- Sun, Yu -- Gampala, Srinivas S L -- Gendron, Nathan -- Sun, Catherine Qing -- Wang, Zhi-Yong -- 5T32GM007276/GM/NIGMS NIH HHS/ -- R01 GM066258/GM/NIGMS NIH HHS/ -- R01 GM066258-04/GM/NIGMS NIH HHS/ -- R01 GM66258-01/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Mar 11;307(5715):1634-8. Epub 2005 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15681342" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/*genetics/growth & development/physiology
;
Arabidopsis Proteins/genetics/*metabolism
;
Base Sequence
;
Binding Sites
;
Chromatin Immunoprecipitation
;
DNA-Binding Proteins/genetics/*metabolism
;
Feedback, Physiological
;
*Gene Expression Regulation, Plant
;
Genes, Plant
;
Genes, Reporter
;
Homeostasis
;
Light
;
Mutation
;
Nuclear Proteins/genetics/*metabolism
;
Oligonucleotide Array Sequence Analysis
;
Phenotype
;
Plant Growth Regulators/biosynthesis/*metabolism/pharmacology
;
Plants, Genetically Modified
;
Promoter Regions, Genetic
;
Recombinant Fusion Proteins/metabolism
;
Repressor Proteins/metabolism
;
*Signal Transduction
;
Steroids/biosynthesis/*metabolism/pharmacology
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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