Publication Date:
1992-08-21
Description:
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kang, S M -- Beverly, B -- Tran, A C -- Brorson, K -- Schwartz, R H -- Lenardo, M J -- New York, N.Y. -- Science. 1992 Aug 21;257(5073):1134-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1509265" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/immunology
;
Antigens/*immunology
;
Base Sequence
;
Binding Sites
;
Blotting, Northern
;
Cell Line
;
Concanavalin A/pharmacology
;
*Gene Expression Regulation
;
*Immune Tolerance
;
Interleukin-2/*genetics/pharmacology
;
Mice
;
Molecular Sequence Data
;
Mutation
;
Promoter Regions, Genetic/genetics
;
Proto-Oncogene Proteins c-jun/*physiology
;
RNA, Messenger/metabolism
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocytes/*immunology
;
Transcription, Genetic
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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