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  • 1
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    The thermal structure of continental crust in active orogens: insight from Miocene eclogite and granulite xenoliths of the Pamir Mountains (2012)
    Wiley
    Details
    Publication Date: 2012-04-15
    Description: Rare ultrahigh-temperature–(near)ultrahigh-pressure (UHT–near-UHP) crustal xenoliths erupted at 11 Ma in the Pamir Mountains, southeastern Tajikistan, preserve a compositional and thermal record at mantle depths of crustal material subducted beneath the largest collisional orogen on Earth. A combination of oxygen-isotope thermometry, major-element thermobarometry and pseudosection analysis reveals that, prior to eruption, the xenoliths partially equilibrated at conditions ranging from 815 °C at 19 kbar to 1100 °C at 27 kbar for eclogites and granulites, and 884 °C at 20 kbar to 1012 °C at 33 kbar for garnet–phlogopite websterites. To reach these conditions, the eclogites and granulites must have undergone mica-dehydration melting. The extraction depths exceed the present-day Pamir Moho at ∼65 km depth and suggest an average thermal gradient of ∼12–13 °C km −1 . The relatively cold geotherm implies the introduction of these rocks to mantle depths by subduction or gravitational foundering (transient crustal drip). The xenoliths provide a window into a part of the orogenic history in which crustal material reached UHT–(U)HP conditions, partially melted, and then decompressed, without being overprinted by the later post-thermal relaxation history.
    Print ISSN: 0263-4929
    Electronic ISSN: 1525-1314
    Topics: Geosciences
    Published by Wiley
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  • 2
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    Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-07-19
    Description: When intracellular pathogens invade mammalian hosts, naive CD8+ T cells differentiate into cytotoxic killers, which lyse infected target cells and secrete cytokines that activate intracellular microbicides. We show that CD8+ T cells deficient in the transcription factors T-bet and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus. Instead, virus-specific CD8+ T cells lacking both T-bet and Eomes differentiate into an interleukin-17-secreting lineage, reminiscent of the helper T cell fate that has been implicated in autoimmunity and extracellular microbial defense. Upon viral infection, mice with T cells lacking both T-bet and Eomes develop a CD8+ T cell-dependent, progressive inflammatory and wasting syndrome characterized by multi-organ infiltration of neutrophils. T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807624/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807624/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Intlekofer, Andrew M -- Banerjee, Arnob -- Takemoto, Naofumi -- Gordon, Scott M -- Dejong, Caitlin S -- Shin, Haina -- Hunter, Christopher A -- Wherry, E John -- Lindsten, Tullia -- Reiner, Steven L -- AI007532/AI/NIAID NIH HHS/ -- AI042334/AI/NIAID NIH HHS/ -- AI042370/AI/NIAID NIH HHS/ -- AI061699/AI/NIAID NIH HHS/ -- AI071309/AI/NIAID NIH HHS/ -- AI076458/AI/NIAID NIH HHS/ -- R01 AI042370/AI/NIAID NIH HHS/ -- R01 AI042370-12/AI/NIAID NIH HHS/ -- R01 AI061699/AI/NIAID NIH HHS/ -- R01 AI061699-05/AI/NIAID NIH HHS/ -- R01 AI071309/AI/NIAID NIH HHS/ -- R01 AI071309-01/AI/NIAID NIH HHS/ -- R01 AI076458/AI/NIAID NIH HHS/ -- R01 AI076458-02/AI/NIAID NIH HHS/ -- T32 CA009140/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):408-11. doi: 10.1126/science.1159806.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635804" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Viral/immunology ; Arenaviridae Infections/*immunology/pathology/virology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/*immunology/*metabolism ; Cell Differentiation ; Cytotoxicity, Immunologic ; Interferon-gamma/metabolism ; Interleukin-17/*metabolism ; Lymphocyte Depletion ; *Lymphocytic choriomeningitis virus/immunology/isolation & ; purification/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; T-Box Domain Proteins/deficiency/genetics/*physiology ; Virus Replication ; Wasting Syndrome/immunology/pathology/virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Transfer of metasupracrustal rocks to mid to lower crustal depths in the North Cascades continental magmatic arc, Skagit Gneiss Complex, Washington (2017)
    Wiley
    In: Tectonics
    Details
    Publication Date: 2017-12-03
    Description: The metasupracrustal units within the north-central Chelan block of the North Cascades Range, Washington are investigated to determine mechanisms and timescales of supracrustal rock incorporation into the deep crust of continental magmatic arcs. Zircon U-Pb and Hf-isotope analyses were used to characterize the protoliths of metasedimentary and metaigneous rocks from the Skagit Gneiss Complex, metasupracrustal rocks from the Cascade River Schist, and metavolcanic rocks from the Napeequa Schist. Skagit Gneiss Complex metasedimentary rocks have: (1) a wide range of zircon U-Pb dates from Proterozoic to latest Cretaceous and (2) a more limited range of dates, from Late Triassic to latest Cretaceous, and a lack of Proterozoic dates. Two samples from the Cascade River Schist are characterized by Late Cretaceous protoliths. Amphibolites from the Napeequa Schist have Late Triassic protoliths. Similarities between the Skagit Gneiss metasediments and accretionary wedge and forearc sediments in northwestern Washington and southern California indicate that the protolith for these units was likely deposited in a forearc basin and/or accretionary wedge in the Early to Late Cretaceous (ca. 134–79 Ma). Sediment was likely underthrust into the active arc by ca. 74–65 Ma, as soon as 7 m.y. after deposition, and intruded by voluminous magmas. The incorporation of metasupracrustal units aligns with the timing of major arc magmatism in the North Cascades (ca. 79–60 Ma) and may indicate a link between the burial of sediments and pluton emplacement.
    Print ISSN: 0278-7407
    Electronic ISSN: 1944-9194
    Topics: Geosciences
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 4
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    The giant Shakhdara migmatitic gneiss dome, Pamir, India–Asia collision zone, I: Geometry and kinematics (2013)
    Wiley
    In: Tectonics
    Details
    Publication Date: 2013-06-30
    Description: [1]  Cenozoic gneiss domes comprise one third of the surface exposure of the Pamir and provide a window into deep crustal processes of the India–Asia collision. The largest of these are the doubly–vergent, composite Shakhdara–Alichur domes of the southwestern Pamir, Tajikistan and Afghanistan; they are separated by a low-strain horst. Top-to-SSE, non-coaxial pervasive flow over the up to 4 km thick South Pamir shear zone exhumed crust from 30–40 km depth in the ~250 × 80 km Shakhdara dome; the top-to-NNE Alichur shear zone exposed upper crustal rocks in the ~125 × 25 km Alichur dome. The Gunt shear zone bounds the Shakhdara dome in the north and records alternations of normal shear and dextral transpression; it contributed little to bulk exhumation. Footwall exhumation along two low-angle, normal-sense detachments resulted in up to 90 km syn-orogenic ~ N–S extension. Extension in the southwestern Pamir opposes shortening in a fold-thrust belt north of the domes and in particular in the Tajik depression, where an evaporitic décollement facilitated upper crustal shortening. Gravitational collapse of the Pamir-plateau margin drove core-complex formation in the southwestern Pamir and shortening of the weak foreland adjacent to the plateau. Overall, this geometry defines a ‘vertical extrusion’ scenario, comprising frontal and basal underthrusting and thickening, and hanging gravitationally driven normal shear. In contrast to the Himalayan vertical extrusion scenario, erosion in the Pamir was minor, preserving most of the extruded deep crust, including the top of the South Pamir shear zone at peak elevations throughout the dome.
    Print ISSN: 0278-7407
    Electronic ISSN: 1944-9194
    Topics: Geosciences
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Electronic Resource
    Electronic Resource
    Theoretical Prediction of the Stationary Phase Contribution to the Plate Height in Chromatography. (1964)
    s.l. : American Chemical Society
    Analytical chemistry 36 (1964), S. 750-753 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60210a016
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Mobile Phase of Effects in packed Liquid Chromatography Columns. (1963)
    s.l. : American Chemical Society
    Analytical chemistry 35 (1963), S. 1537-1539 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60203a034
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of Crystalline Progesterone with 2,4-Dinitrophenylhydrazine (1948)
    s.l. : American Chemical Society
    Analytical chemistry 20 (1948), S. 174-176 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60014a020
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  • 8
    Electronic Resource
    Electronic Resource
    Vitellogenesis and trace metals in a marine teleost (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 18 (1981), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The concentration and loss of copper and cadmium over the spawning period in relation to vitellogenesis in Blennius pholis L. and the implications for the viability of the developing embryo are described and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1981.tb03776.x
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  • 9
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    Linking deep and shallow crustal processes during regional transtension in an exhumed continental arc, North Cascades, northwestern Cordillera (USA) (2016)
    Geological Society of America (GSA)
    In: Geosphere
    Details
    Publication Date: 2016-05-29
    Description: The North Cascades orogen (northwestern USA) provides an exceptional natural laboratory with which to evaluate potential temporal and kinematic links between processes operating at a wide range of crustal levels during collapse of a continental arc, and particularly the compatibility of strain between the upper and lower crust. This magmatic arc reached a crustal thickness of ≥55 km in the mid-Cretaceous. Eocene collapse of the arc during regional transtension was marked by magmatism, migmatization, ductile flow, and exhumation of deep crustal (8–12 kbar) rocks in the Cascades crystalline core coeval with subsidence and rapid deposition in nonmarine basins adjacent to the core, and intrusion of dike complexes. The Skagit Gneiss Complex is the larger of two regions of exhumed deep crust with Eocene cooling ages in the Cascades core, and it consists primarily of tonalitic orthogneiss emplaced mainly in two episodes of ca. 73–59 Ma and 50–45 Ma. Metamorphism, melt crystallization, and ductile deformation of migmatitic metapelite overlap the orthogneiss emplacement, occurring (possibly intermittently) from ca. 71 to 53 Ma; the youngest orthogneisses overlap 40 Ar/ 39 Ar biotite dates, compatible with rapid cooling. Gently to moderately dipping foliation, subhorizontal orogen-parallel (northwest-southeast) mineral lineation, sizable constrictional domains, and strong stretching parallel to lineation of hinges of mesoscopic folds in the Skagit Gneiss Complex are compatible with transtension linked to dextral-normal displacement of the Ross Lake fault zone, the northeastern boundary of the Cascades core. The other deeply exhumed domain, the 9–12 kbar Swakane Biotite Gneiss, has a broadly north-trending, gently plunging lineation and gently to moderately dipping foliation, which are associated with top-to-the-north noncoaxial shear. This gneiss is separated from overlying metamorphic rocks by a folded detachment fault. The Eocene Swauk and Chumstick basins flank the southern end of the Cascades core. In the Swauk basin, sediments were deposited in part at ca. 51 Ma, folded shortly afterward, and then covered by ca. 49 Ma Teanaway basalts and intruded by associated mafic dikes. Directly after dike intrusion, the fault-bounded Chumstick basin subsided rapidly. Extension directions from these dikes and from Eocene dikes that intruded the Cascades core are dominantly oblique to the overall trend of the orogen (275°–310° versus ~320°, respectively) and to the northwest-southeast to north-south ductile flow direction in the Skagit and Swakane rocks. This discordance implies that coeval extensional strain was decoupled between the brittle and ductile crust. Strain orientations at all depths in the Cascades core contrast with the approximately east-west extension driven by orogenic collapse in coeval metamorphic core complexes ~200 km to the east. Arc-oblique to arc-parallel flow in the Cascades core probably resulted in part from dextral shear along the plate margin and from along-strike gradients in crustal thickness and temperature.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 10
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    Genenames.org: the HGNC resources in 2013 (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-20
    Description: The HUGO Gene Nomenclature Committee situated at the European Bioinformatics Institute assigns unique symbols and names to human genes. Since 2011, the data within our database has expanded largely owing to an increase in naming pseudogenes and non-coding RNA genes, and we now have 〉33 500 approved symbols. Our gene families and groups have also increased to nearly 500, with ~45% of our gene entries associated to at least one family or group. We have also redesigned the HUGO Gene Nomenclature Committee website http://www.genenames.org creating a constant look and feel across the site and improving usability and readability for our users. The site provides a public access portal to our database with no restrictions imposed on access or the use of the data. Within this article, we review our online resources and data with particular emphasis on the updates to our website.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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