Publication Date:
2016-01-09
Description:
The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these gamma-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Basu, Jayeeta -- Zaremba, Jeffrey D -- Cheung, Stephanie K -- Hitti, Frederick L -- Zemelman, Boris V -- Losonczy, Attila -- Siegelbaum, Steven A -- 1R01MH100510/MH/NIMH NIH HHS/ -- 1R01MH100631/MH/NIMH NIH HHS/ -- R01NS036658/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2016 Jan 8;351(6269):aaa5694. doi: 10.1126/science.aaa5694.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Kavli Brain Institute, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA. jayeeta.basu@nyumc.org sas8@columbia.edu. ; Department of Neuroscience, Kavli Brain Institute, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA. ; University of Texas at Austin, Austin, TX 78712, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26744409" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CA1 Region, Hippocampal/*physiology
;
CA3 Region, Hippocampal/physiology
;
Dendrites/physiology
;
Entorhinal Cortex/*physiology
;
Evoked Potentials/physiology
;
GABAergic Neurons/physiology
;
Inhibitory Postsynaptic Potentials/*physiology
;
Memory, Long-Term/*physiology
;
Mice
;
Neuronal Plasticity/*physiology
;
Pyramidal Cells/physiology
;
Synapses/physiology
;
gamma-Aminobutyric Acid/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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