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  • 1
    Monograph available for loan
    Monograph available for loan
    Applied demography : Applications to business, government, law, and public policy (2002)
    Orlando [u.a.] : Academic Press
    Details Availability
    Call number: PIK B 040-04-0010
    Type of Medium: Monograph available for loan
    Pages: XXII ; 686 S.
    ISBN: 0126418403
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
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    Thermal analysis on Al7075/Al 2 O 3 metal matrix composites fabricated by stir casting process (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-03-11
    Description: Metal matrix Composites (MMC’s) have evoked a keen interest in recent times for various applications in aerospace, renewable energy and automotive industries due to their superior strength, low cost, easy availability and high temperature resistance [1]. The crack and propagation occurs in conventional materials without any appreciable indication in a short span. Hence composite materials are preferred nowadays to overcome this problem [2]. The process of metal matrix composites (MMC’s) is to unite the enviable attributes of metals and ceramics. The Stir casting method is used for producing aluminium metal matrix composites (AMC’s). A key challenge of the process is to spread the ceramic particles to achieve a defect free microstructure [2]. By carefully selecting stir casting processing specification, such as stirring time, temperature of the melt and blade angle, the desired microstructure can be obtained. The focus of this work is to develop a high strength particulate streng...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 3
    Electronic Resource
    Electronic Resource
    Stoompakketvaart op Noord-Amerika (1871)
    Springer
    De economist 20 (1871), S. 602-637 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180839
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Boekbespreking (1954)
    Springer
    European journal of plant pathology 60 (1954), S. 128-130 
    Details
    ISSN: 1573-8469
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151106
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A dual perturbation view of linear programming (1996)
    Springer
    Mathematical methods of operations research 44 (1996), S. 1-9 
    Details
    ISSN: 1432-5217
    Keywords: Linear Programming ; Duality Theory ; Perturbation Methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract Solving standard-form linear prograrns via perturbation of the primal objective function has received much attention recently. In this paper, we investigate a new perturbation scheme which obtains a dual optimal solution by perturbing the dual feasible domain under different norms. A dual-to-primal conversion formula is also provided. We show that this new perturbation scheme actually generalizes the primal entropic perturbation approach to linear programming.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01246326
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  • 6
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    Large dust aerosol sizes seen during the 2018 Martian global dust event by the Curiosity rover (2019)
    Wiley
    Details
    Publication Date: 2019
    Description: Abstract Mars’ atmosphere typically supports dust aerosol with an effective radius near 1.5 μm, varying from ~1 μm during low dust times near northern summer solstice to ~2 μm during higher dust times in southern spring and summer. After global dust events, size variations outside this range have not previously been observed. We report on imaging and spectral observations by the Curiosity rover through the 2018 global dust event. These observations show that the dust effective radius was seasonally normal prior to the local onset of increased opacity, increased rapidly above 4 μm with increasing opacity, remained above 3 μm over a period of ~50 Martian solar days, then returned to seasonal values before the opacity did so. This demonstrates lifting and regional scale transport of a dust population ~3 times the size of typical dust aerosol.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    Development of a high-resolution NGS-based HLA-typing and analysis pipeline (2015)
    Oxford University Press
    Details
    Publication Date: 2015-06-24
    Description: The human leukocyte antigen (HLA) complex contains the most polymorphic genes in the human genome. The classical HLA class I and II genes define the specificity of adaptive immune responses. Genetic variation at the HLA genes is associated with susceptibility to autoimmune and infectious diseases and plays a major role in transplantation medicine and immunology. Currently, the HLA genes are characterized using Sanger- or next-generation sequencing (NGS) of a limited amplicon repertoire or labeled oligonucleotides for allele-specific sequences. High-quality NGS-based methods are in proprietary use and not publicly available. Here, we introduce the first highly automated open-kit/open-source HLA-typing method for NGS. The method employs in-solution targeted capturing of the classical class I ( HLA-A, HLA-B, HLA-C ) and class II HLA genes ( HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DPA1, HLA-DPB1 ). The calling algorithm allows for highly confident allele-calling to three-field resolution (cDNA nucleotide variants). The method was validated on 357 commercially available DNA samples with known HLA alleles obtained by classical typing. Our results showed on average an accurate allele call rate of 0.99 in a fully automated manner, identifying also errors in the reference data. Finally, our method provides the flexibility to add further enrichment target regions.
    Keywords: Polymorphism/mutation detection, Computational Methods
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 8
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    On the impact of topography and building mask on time varying gravity due to local hydrology (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-19
    Description: We use 3 yr of surface absolute gravity measurements at three sites on the Larzac plateau (France) to quantify the changes induced by topography and the building on gravity time-series, with respect to an idealized infinite slab approximation. Indeed, local topography and buildings housing ground-based gravity measurement have an effect on the distribution of water storage changes, therefore affecting the associated gravity signal. We first calculate the effects of surrounding topography and building dimensions on the gravity attraction for a uniform layer of water. We show that a gravimetric interpretation of water storage change using an infinite slab, the so-called Bouguer approximation, is generally not suitable. We propose to split the time varying gravity signal in two parts (1) a surface component including topographic and building effects (2) a deep component associated to underground water transfer. A reservoir modelling scheme is herein presented to remove the local site effects and to invert for the effective hydrological properties of the unsaturated zone. We show that effective time constants associated to water transfer vary greatly from site to site. We propose that our modelling scheme can be used to correct for the local site effects on gravity at any site presenting a departure from a flat topography. Depending on sites, the corrected signal can exceed measured values by 5–15 μGal, corresponding to 120–380 mm of water using the Bouguer slab formula. Our approach only requires the knowledge of daily precipitation corrected for evapotranspiration. Therefore, it can be a useful tool to correct any kind of gravimetric time-series data.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 9
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    Redemption from original antigenic sin [Immunology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-08-22
    Description: Original antigenic sin is a phenomenon wherein sequential exposure to closely related influenza virus variants reduces antibody (Ab) response to novel antigenic determinants in the second strain and, consequently, impairs the development of immune memory. This could pose a risk to the development of immune memory in persons previously infected...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    NFATc4 in adult hippocampal neurogenesis [Neuroscience] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-06-06
    Description: New neurons generated in the adult dentate gyrus are constantly integrated into the hippocampal circuitry and activated during encoding and recall of new memories. Despite identification of extracellular signals that regulate survival and integration of adult-born neurons such as neurotrophins and neurotransmitters, the nature of the intracellular modulators required to transduce those signals remains elusive. Here, we provide evidence of the expression and transcriptional activity of nuclear factor of activated T cell c4 (NFATc4) in hippocampal progenitor cells. We show that NFATc4 calcineurin-dependent activity is required selectively for survival of adult-born neurons in response to BDNF signaling. Indeed, cyclosporin A injection and stereotaxic delivery of the BDNF scavenger TrkB-Fc in the mouse dentate gyrus reduce the survival of hippocampal adult-born neurons in wild-type but not in NFATc4−/− mice and do not affect the net rate of neural precursor proliferation and their fate commitment. Furthermore, associated with the reduced survival of adult-born neurons, the absence of NFATc4 leads to selective defects in LTP and in the encoding of hippocampal-dependent spatial memories. Thus, our data demonstrate that NFATc4 is essential in the regulation of adult hippocampal neurogenesis and identify NFATc4 as a central player of BDNF–driven prosurvival signaling in hippocampal adult-born neurons.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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