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  • 1
    Publication Date: 2016-03-23
    Description: Author(s): B. Moon, S. Yoo, J.-S. Kim, S. J. Kang, J. Muñoz-García, and R. Cuerno We report experiments on surface nanopatterning of Si targets which are irradiated with 2-keV Ar + ions impinging at near-glancing incidence, under concurrent codeposition of Au impurities simultaneously extracted from a gold target by the same ion beam. Previous recent experiments by a number of gro… [Phys. Rev. B 93, 115430] Published Tue Mar 22, 2016
    Keywords: Surface physics, nanoscale physics, low-dimensional systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2015-08-29
    Description: Np63 is required for both the proliferation and differentiation of keratinocytes, but its role in the differentiation of these cells is poorly understood. The corresponding gene, TP63 , harbors the MIR944 sequence within its intron. However, the mechanism of biogenesis and the function of miR-944 are unknown. We found that miR-944 is highly expressed in keratinocytes, in a manner that is concordant with that of Np63 mRNA, but the regulation of miR-944 expression under various conditions did not correspond with that of Np63 . Bioinformatics analysis and functional studies demonstrated that MIR944 has its own promoter. We demonstrate here that MIR944 is a target of Np63. Promoter analysis revealed that the activity of the MIR944 promoter was markedly enhanced by the binding of Np63, which was maintained by the supportive action of AP-2 during keratinocyte differentiation. Our results indicated that miR-944 biogenesis is dependent on Np63 protein, even though it is generated from Np63 mRNA-independent transcripts. We also demonstrated that miR-944 induces keratin 1 and keratin 10 expression by inhibiting ERK signaling and upregulating p53 expression. Our findings suggested that miR-944, as an intronic miRNA and a direct target of Np63, contributes to the function of Np63 in the induction of epidermal differentiation.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 3
    Publication Date: 2015-10-21
    Description: Epstein-Barr virus (EBV) infection causes both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). The present study reveals that EBV-induced HL and NHL are intriguingly associated with a repopulated immune cell profile in humanized mice. Newborn immunodeficient NSG mice were engrafted with human cord blood CD34+ hematopoietic stem cells (HSCs) for...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 4
    Publication Date: 2006-12-16
    Description: We developed a simple approach to combine broad classes of dissimilar materials into heterogeneously integrated electronic systems with two- or three-dimensional layouts. The process begins with the synthesis of different semiconductor nanomaterials, such as single-walled carbon nanotubes and single-crystal micro- and nanoscale wires and ribbons of gallium nitride, silicon, and gallium arsenide on separate substrates. Repeated application of an additive, transfer printing process that uses soft stamps with these substrates as donors, followed by device and interconnect formation, yields high-performance heterogeneously integrated electronics that incorporate any combination of semiconductor nanomaterials on rigid or flexible device substrates. This versatile methodology can produce a wide range of unusual electronic systems that would be impossible to achieve with other techniques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ahn, Jong-Hyun -- Kim, Hoon-Sik -- Lee, Keon Jae -- Jeon, Seokwoo -- Kang, Seong Jun -- Sun, Yugang -- Nuzzo, Ralph G -- Rogers, John A -- New York, N.Y. -- Science. 2006 Dec 15;314(5806):1754-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering, University of Illinois, Urbana-Champaign, IL 61801, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17170298" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2015-10-03
    Description: Memory stabilization after learning requires translational and transcriptional regulations in the brain, yet the temporal molecular changes that occur after learning have not been explored at the genomic scale. We used ribosome profiling and RNA sequencing to quantify the translational status and transcript levels in the mouse hippocampus after contextual fear conditioning. We revealed three types of repressive regulations: translational suppression of ribosomal protein-coding genes in the hippocampus, learning-induced early translational repression of specific genes, and late persistent suppression of a subset of genes via inhibition of estrogen receptor 1 (ESR1/ERalpha) signaling. In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation. Collectively, this study unveils the yet-unappreciated importance of gene repression mechanisms for memory formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Jun -- Yu, Nam-Kyung -- Choi, Jun-Hyeok -- Sim, Su-Eon -- Kang, SukJae Joshua -- Kwak, Chuljung -- Lee, Seung-Woo -- Kim, Ji-il -- Choi, Dong Il -- Kim, V Narry -- Kaang, Bong-Kiun -- New York, N.Y. -- Science. 2015 Oct 2;350(6256):82-7. doi: 10.1126/science.aac7368.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea. Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. ; Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea. Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. narrykim@snu.ac.kr kaang@snu.ac.kr. ; Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. narrykim@snu.ac.kr kaang@snu.ac.kr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26430118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Conditioning, Classical ; Estrogen Receptor alpha/*genetics ; Fear ; *Gene Expression Regulation ; Hippocampus/*metabolism ; Male ; Membrane Proteins/*genetics ; *Memory ; Mice ; Mice, Inbred C57BL ; Protein Biosynthesis/*genetics ; Ribosomal Proteins/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2014-07-29
    Description: We report the enhancement of the minority carrier lifetime of GaInP with a lateral composition modulated (LCM) structure grown using molecular beam epitaxy (MBE). The structural and optical properties of the grown samples are studied by transmission electron microscopy and photoluminescence, which reveal the formation of vertically aligned bright and dark slabs corresponding to Ga-rich and In-rich GaInP regions, respectively, with good crystal quality. With the decrease of V/III ratio during LCM GaInP growth, it is seen that the band gap of LCM GaInP is reduced, while the PL intensity remains high and is comparable to that of bulk GaInP. We also investigate the minority carrier lifetime of LCM structures made with different flux ratios. It is found that the minority carrier lifetime of LCM GaInP is ∼37 times larger than that of bulk GaInP material, due to the spatial separation of electrons and holes by In-rich and Ga-rich regions of the LCM GaInP, respectively. We further demonstrate that the minority carrier lifetime of the grown LCM GaInP structures can easily be tuned by simply adjusting the V/III flux ratio during MBE growth, providing a simple yet powerful technique to tailor the electrical and optical properties at will. The exceptionally high carrier lifetime and the reduced band gap of LCM GaInP make them a highly attractive candidate for forming the top cell of multi-junction solar cells and can enhance their efficiency, and also make them suitable for other optoelectronics devices, such as photodetectors, where longer carrier lifetime is beneficial.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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  • 7
    Publication Date: 2013-11-15
    Description: (ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease Cell Death and Disease 4, e919 (November 2013). doi:10.1038/cddis.2013.447 Authors: T W Kim, H M Cho, S Y Choi, Y Suguira, T Hayasaka, M Setou, H C Koh, E Mi Hwang, J Y Park, S J Kang, H S Kim, H Kim & W Sun
    Keywords: PARP-1ATPAMPK6-OHDAParkinson’s disease
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 83 (1998), S. 7130-7132 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The hydrogenation, disproportionation, desorption, recombination (HDDR) is known as a unique process through which a noncoercive cast Nd–Fe–B-type material can be easily converted into a coercive one. Although the conventional HDDR process generally leads to a powderlike material, a solid-HDDR material can be realized if the HDDR process is properly modified (solid-HDDR). In the present study, the change of mechanical strength (compressive strength) of the Nd–Fe–B-type material during the solid-HDDR has been investigated using a sintered magnet with composition Nd13.8Dy0.7Fe78.25Si0.15Mn0.6B6.5. It has been found that the low strength of the hydrided material was improved by the subsequent disproportionation. The restoration of the strength was explained by the eutectoidlike disproportionation structure containing fine neodymium hydride rod embedded in tough iron matrix. The high strength of disproportionated material was reduced radically in an earlier stage of recombination, and this was explained by the reduction of the disproportionated phase. The reduced strength was, however, recovered by further recombination, and this was explained by the fact that as the recombination continues the recombined grains become continuous and adhere together. The optimally HDDR processed material has a comparable or even higher strength with respect to the initial sintered material prior to the solid-HDDR. The present study suggested that the mechanical strength of Nd–Fe–B-type material could be retained even after the solid-HDDR. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 2 (1983), S. 291-294 
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 18 (1983), S. 1374-1380 
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The effect of heat-treatment in vacuum and hydrogen on the ductility and UTS of the sintered 96W-2.8Ni-1.2Fe (by wt%) heavy alloy has been studied. The elongation of the as-sintered alloy is about 8%, but after a few minutes of heat treatment in vacuum at 800° C it increases markedly to about 19%. When the sintered specimen is heat-treated in vacuum at 600° C, the elongation increases rapidly with time, reaching 20% after about 10 min. The values of UTS also increase after vacuum treatment. Heat treatment in hydrogen, however, shows no change in mechanical properties from the as-sintered state. The effect of vacuum treatment is thus attributed to the removal of hydrogen embrittlement. Based on the hydrogen diffusion model, a practical guide line is suggested for determining the optimum vacuum treatment conditions. The scanning electron micrographs of the fracture surfaces show that hydrogen weakens mainly the interface between tungsten grains and matrix.
    Type of Medium: Electronic Resource
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