Publication Date:
2015-12-17
Description:
Domoic acid (DA) is a naturally occurring neurotoxin known to harm marine animals. DA-producing algal blooms are increasing in size and frequency. Although chronic exposure is known to produce brain lesions, the influence of DA toxicosis on behavior in wild animals is unknown. We showed, in a large sample of wild sea lions, that spatial memory deficits are predicted by the extent of right dorsal hippocampal lesions related to natural exposure to DA and that exposure also disrupts hippocampal-thalamic brain networks. Because sea lions are dynamic foragers that rely on flexible navigation, impaired spatial memory may affect survival in the wild.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, Peter F -- Reichmuth, Colleen -- Rouse, Andrew A -- Libby, Laura A -- Dennison, Sophie E -- Carmichael, Owen T -- Kruse-Elliott, Kris T -- Bloom, Josh -- Singh, Baljeet -- Fravel, Vanessa A -- Barbosa, Lorraine -- Stuppino, Jim J -- Van Bonn, William G -- Gulland, Frances M D -- Ranganath, Charan -- New York, N.Y. -- Science. 2015 Dec 18;350(6267):1545-7. doi: 10.1126/science.aac5675. Epub 2015 Dec 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neuropolicy, Emory University, Atlanta, GA 30322, USA. Pinniped Cognition and Sensory Systems Laboratory, Institute of Marine Sciences, University of California-Santa Cruz, Santa Cruz, CA 95060, USA. pfcook@emory.edu. ; Pinniped Cognition and Sensory Systems Laboratory, Institute of Marine Sciences, University of California-Santa Cruz, Santa Cruz, CA 95060, USA. ; Dynamic Memory Lab, Center for Neuroscience, University of California-Davis, Davis, CA 95618, USA. ; AnimalScan Advanced Veterinary Imaging, Redwood City, CA 94063, USA. ; Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. ; The Marine Mammal Center, Sausalito, CA 94965, USA. ; Shedd Aquarium, Chicago, IL 60605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26668068" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Eutrophication
;
Hippocampus/*drug effects/physiology
;
Kainic Acid/*analogs & derivatives/metabolism/toxicity
;
Marine Toxins/*toxicity
;
Neurotoxins/metabolism/*toxicity
;
Sea Lions/*physiology
;
Spatial Memory/*drug effects
;
Thalamus/drug effects/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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