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  • 1
    Publication Date: 2015-10-07
    Description: Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing data with reference to methylation profiles of different tissues, we developed a general approach for studying the major tissue contributors to the circulating DNA pool. We tested...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 2
    Publication Date: 2019
    Description: There has been no subsequent meta-analysis examining the effects of long working hours on health or occupational health since 1997. Therefore, this paper aims to conduct a meta-analysis covering studies after 1997 for a comparison. A total of 243 published records were extracted from electronic databases. The effects were measured by five conditions, namely, physiological health (PH), mental health (MH), health behaviours (HB), related health (RH), and nonspecified health (NH). The overall odds ratio between long working hours and occupational health was 1.245 (95% confidence interval (CI): 1.195–1.298). The condition of related health constituted the highest odds ratio value (1.465, 95% CI: 1.332–1.611). The potential moderators were study method, cut-point for long weekly working hours, and country of origin. Long working hours were shown to adversely affect the occupational health of workers. The management on safeguarding the occupational health of workers working long hours should be reinforced.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by MDPI
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  • 3
    Publication Date: 2015-02-24
    Description: Yard truck scheduling and storage allocation problems (YTS-SAP) are two important issues that influence the efficiency of a container terminal. These two problems aim to determine the routing of trucks and proper storage locations for discharging containers from incoming vessels. This paper integrates YTS and SAP as a whole and tries to minimize the weighted summation of total delay and total yard trucks travel time. A genetic algorithm (GA) is proposed to deal with the problem. In the proposed GA, guidance mutation approach and exhaustive heuristic for local searching are used in order to force the GA to converge faster and be steadier. To test the performance of the proposed GA, both small scale and large scale cases are studied. The results of these cases are compared with CPLEX for the small scale cases. Since this problem is an NP-hard problem, which CPLEX cannot solve, a simple GA is studied for comparison in large scale cases. The comparison demonstrates that the proposed GA can obtain near optimal solutions in much shorter computational time for small scale cases. In addition, the proposed GA can obtain better results than other methods in reasonable time for large scale cases.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 4
    Publication Date: 2013-08-22
    Description: Tam, Y-K., Ni, I-H., Yau, C., Yan, M-Y., Chan, W-S., Chan, S-M., Lu, H-J. 2013. Tracking the changes of a fish community following a megascale reclamation and ensuing mitigation measures. – ICES Journal of Marine Science, 70: 1206–1219. A fish community in Hong Kong that had experienced megascale reclamation in Chek Lap Kok International Airport, and the ensuing marine protected areas (MPAs) establishment was tracked for 12 years. Significant shifts in community structure, typified by 17 species, were revealed by multivariate analyses and community metrics. Dynamic factor analysis disclosed two underlying common trends among them and their significant correlations with changes in water quality, area of seabed disturbance, and area of MPAs. A time-lag for detectable community changes was also revealed. During reclamation, the fish density was low and community health was poor. Large species disappeared leaving a community dominated by small, fast-growing and young-to-mature species. After completion of reclamation, some large and medium species returned, but soon after the establishment of MPAs, medium-sized, fast-growing and young-to-mature species thrived on reduction of fishing pressure, and filled the guilds rapidly. Therefore, even though fish density and community health were improved, the original community structure was not restored. This study provides a good reference for impacts of reclamation at the community level and the possible outcomes of reducing fishing pressure in a depleted fish community.
    Print ISSN: 1054-3139
    Electronic ISSN: 1095-9289
    Topics: Biology , Geosciences , Physics
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  • 5
    Publication Date: 2015-02-26
    Description: This paper investigates the economic production quantity model jointly considering product deterioration and a deteriorating production system with rework. In this imperfect deteriorating production system, not only does the machine produce defective product but also the machine is subjected to quality deterioration. To be more specific, the defective rate increases at certain time intervals. The defects produced are stored until the end of normal production process. Then they are reworked with extra cost to restore their quality and regarded as perfect product. The main objective is to minimize the total cost per unit product by determining the optimal combination of production run time and backlog quantity. Numerical experiments are carried out to illustrate the behavior of the inventory and show the impact of different parameters on the model. Discussion and conclusions are made at the end of the paper.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 6
    Electronic Resource
    Electronic Resource
    Bingley : Emerald
    The @journal of product & brand management 13 (2004), S. 359-368 
    ISSN: 1061-0421
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Most pricing studies assume that firms have complete information about demand. In practice, managers must make decisions, given incomplete information about the demand for their own products as well as those of their rivals. This paper develops a duopoly pricing model in which firms market differentiated products in a world of uncertainty. Results show that the predictions of standard strategic pricing models may not hold when firms face parameter uncertainty and are risk-averse. Under well-defined conditions, there may be a "first-mover" disadvantage to the firm that attempts to be the Stackelberg price leader in the market, especially in a market where demand is highly uncertain. Interestingly, if parameter uncertainty is sufficiently high, it may even be necessary for the price leader to share market information with its rival. When firms are risk-averse, uncertainty generally decreases equilibrium prices and the variabilities of profits.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Marketing letters 4 (1993), S. 337-348 
    ISSN: 1573-059X
    Keywords: Product Design ; Product Competition ; Conjoint Analysis ; Game Theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Notes: Abstract While conjoint analysis has been applied in a wide variety of different contexts in Marketing, most applications fail to explicitly consider retaliatory reactions from competitors. In this paper, a methodological extension is developed for conjoint analysis by explicitly modeling competition in a game theoretic context. The Nash equilibrium concept is employed to model competitive reactions to produce design, and its implications for reactive product strategies are discussed. The optimal product design problem for each firm is formulated as a nonlinear integer programming problem, which is solved via a specialized branch and bound method combined with a heuristic. In order to compute a Nash equilibrium, a sequential iterative procedure is proposed. The proposed procedure is illustrated under several scenarios of competition using previously published conjoint data.
    Type of Medium: Electronic Resource
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  • 8
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    In:  Bull. Seism. Soc. Am., Bonn, Inst. f. Theoret. Geodäsie, vol. 89, no. 6, pp. 1439-1446, pp. L04601, (ISSN: 1340-4202)
    Publication Date: 1999
    Keywords: Seismology ; Fluids ; Earth tides ; BSSA
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  • 9
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    In:  Soil Dynamics and Earthquake Engineering, Taipei, 3-4, vol. 23, no. 3, pp. 563-569, pp. B07303, (ISSN: 1340-4202)
    Publication Date: 2003
    Keywords: Rayleigh waves ; Dispersion ; Earthquake engineering, engineering seismology ; noksp ; SDEE
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  • 10
    Publication Date: 2016-07-13
    Description: Ion implantation of Zn substituting elements in ZnO has been shown to result in a dramatic Li depletion of several microns in hydrothermally grown ZnO. This has been ascribed to a burst of mobile Zn interstials. In this study, we seek to understand the reason behind this interstitial mediated transient enhanced diffusion in Li-containing ZnO samples after Zn implantation. ZnO wafers were implanted with Zn to two doses, 5 × 10 15  cm −2 and 1 × 10 17  cm −2 . Secondary ion mass spectrometry was carried out to profile the Li depletion depth for different annealing temperatures between 600 and 800 °C. The 800 °C annealing had the most significant Li depletion of close to 60  μ m. Transmission electron microscopy (TEM) was carried out in selected samples to identify the reason behind the Li depletion. In particular, TEM investigations of samples annealed at 750 °C show significant Zn precipitation just below the depth of the projected range of the implanted ions. We propose that the Zn precipitation is indicative of Zn supersaturation. Both the Li depletion and Zn precipitation are competing synchronous processes aimed at reducing the excess Zn interstitials.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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