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  • 1
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    Geology of the Brent Group (1992)
    London : The Geological Society
    Details
    Keywords: Marine Geologie ; Erdöl ; Jura ; Brent Group ; Geologie ; Norwegen ; Schelf ; Geology ; North Sea ; Petroleum
    Description / Table of Contents: A. C. Morton, R. S. Haszeldine, M. R. Giles, and S. Brown: Geology of the Brent Group: Introduction / Geological Society, London, Special Publications, 61:1-2, doi:10.1144/GSL.SP.1992.061.01.01 --- J. M. Bowen: Exploration of the Brent Province / Geological Society, London, Special Publications, 61:3-14, doi:10.1144/GSL.SP.1992.061.01.02 --- P. C. Richards: An introduction to the Brent Group: a literature review / Geological Society, London, Special Publications, 61:15-26, doi:10.1144/GSL.SP.1992.061.01.03 --- Graham Yielding, Michael E. Badley, and Alan M. Roberts: The structural evolution of the Brent Province / Geological Society, London, Special Publications, 61:27-43, doi:10.1144/GSL.SP.1992.061.01.04 --- B. C. Mitchener, D. A. Lawrence, M. A. Partington, M. B. J. Bowman, and J. Gluyas: Brent Group: sequence stratigraphy and regional implications / Geological Society, London, Special Publications, 61:45-80, doi:10.1144/GSL.SP.1992.061.01.05 --- S. J. C. Cannon, M. R. Giles, M. F. Whitaker, P. M. Please, and S. V. Martin: A regional reassessment of the Brent Group, UK sector, North Sea / Geological Society, London, Special Publications, 61:81-107, doi:10.1144/GSL.SP.1992.061.01.06 --- W. Helland-Hansen, M. Ashton, L. Lømo, and R. Steel: Advance and retreat of the Brent delta: recent contributions to the depositional model / Geological Society, London, Special Publications, 61:109-127, doi:10.1144/GSL.SP.1992.061.01.07 --- Elaine S. Scott: The palaeoenvironments and dynamics of the Rannoch—Etive nearshore and coastal succession, Brent Group, northern North Sea / Geological Society, London, Special Publications, 61:129-147, doi:10.1144/GSL.SP.1992.061.01.08 --- Jan Alexander: A discussion of alluvial sandstone body characteristics related to variations in marine influence, Middle Jurassic of the Cleveland Basin, UK, and the implications for analogous Brent Group strata in the North Sea Basin / Geological Society, London, Special Publications, 61:149-167, doi:10.1144/GSL.SP.1992.061.01.09 --- M. F. Whitaker, M. R. Giles, and S. J. C. Cannon: Palynological review of the Brent Group, UK sector, north sea / Geological Society, London, Special Publications, 61:169-202, doi:10.1144/GSL.SP.1992.061.01.10 --- Gwydion Williams: Palynology as a palaeoenvironmental indicator in the Brent Group, northern North Sea / Geological Society, London, Special Publications, 61:203-212, doi:10.1144/GSL.SP.1992.061.01.11 --- Euan W. Mearns: Samarium-neodymium isotopic constraints on the provenance of the Brent Group / Geological Society, London, Special Publications, 61:213-225, doi:10.1144/GSL.SP.1992.061.01.12 --- A. C. Morton: Provenance of Brent Group sandstones: heavy mineral constraints / Geological Society, London, Special Publications, 61:227-244, doi:10.1144/GSL.SP.1992.061.01.13 --- K. Stattegger and A. C. Morton: Statistical analysis of garnet compositions and lithostratigraphic correlation: Brent Group sandstones of the Oseberg Field, northern North Sea / Geological Society, London, Special Publications, 61:245-262, doi:10.1144/GSL.SP.1992.061.01.14 --- Knut Bjørlykke, Tor Nedkvitne, Mogens Ramm, and Girish C. Saigal: Diagenetic processes in the Brent Group (Middle Jurassic) reservoirs of the North Sea: an overview / Geological Society, London, Special Publications, 61:263-287, doi:10.1144/GSL.SP.1992.061.01.15 --- M. R. Giles, S. Stevenson, S. V. Martin, S. J. C. Cannon, P. J. Hamilton, J. D. Marshall, and G. M. Samways: The reservoir properties and diagenesis of the Brent Group: a regional perspective / Geological Society, London, Special Publications, 61:289-327, doi:10.1144/GSL.SP.1992.061.01.16 --- J. Reed Glasmann: The fate of feldspar in Brent Group reservoirs, North Sea: a regional synthesis of diagenesis in shallow, intermediate, and deep burial environments / Geological Society, London, Special Publications, 61:329-350, doi:10.1144/GSL.SP.1992.061.01.17 --- Nicholas B. Harris: Burial diagenesis of Brent sandstones: a study of Statfjord, Hutton and Lyell fields / Geological Society, London, Special Publications, 61:351-375, doi:10.1144/GSL.SP.1992.061.01.18 --- P. J. Hamilton, M. R. Giles, and P. Ainsworth: K-Ar dating of illites in Brent Group reservoirs: a regional perspective / Geological Society, London, Special Publications, 61:377-400, doi:10.1144/GSL.SP.1992.061.01.19 --- R. Stuart Haszeldine, J. F. Brint, A. E. Fallick, P. J. Hamilton, and S. Brown: Open and restricted hydrologies in Brent Group diagenesis: North Sea / Geological Society, London, Special Publications, 61:401-419, doi:10.1144/GSL.SP.1992.061.01.20 --- A. J. C. Hogg, E. Sellier, and A. J. Jourdan: Cathodoluminescence of quartz cements in Brent Group sandstones, Alwyn South, UK North Sea / Geological Society, London, Special Publications, 61:421-440, doi:10.1144/GSL.SP.1992.061.01.21 --- Stephen Larter and Idar Horstad: Migration of petroleum into Brent Group reservoirs: some observations from the Gullfaks field, Tampen Spur area North Sea / Geological Society, London, Special Publications, 61:441-452, doi:10.1144/GSL.SP.1992.061.01.22 --- J. D. Kantorowicz, M. R. P. Eigner, S. E. Livera, F. S. Van Schijndel-Goester, and P. J. Hamilton: Integration of petroleum engineering studies of producing Brent Group fields to predict reservoir properties in the Pelican Field, UK North Sea / Geological Society, London, Special Publications, 61:453-469, doi:10.1144/GSL.SP.1992.061.01.23 --- Brian Moss: The petrophysical characteristics of the Brent sandstones / Geological Society, London, Special Publications, 61:471-496, doi:10.1144/GSL.SP.1992.061.01.24 --- Erratum --- Erratum: Brent Group: sequence stratigraphy and regional implications / Geological Society, London, Special Publications, 61:ERR, doi:10.1144/GSL.SP.1992.061.01.26
    Pages: Online-Ressource (506 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 0903317680
    URL: http://sp.lyellcollection.org/content/61/1
    Language: English
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    E-BOOK
  • 2
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    Otitis media in the Tgif knockout mouse implicates TGF{beta} signalling in chronic middle ear inflammatory disease (2013)
    Oxford University Press
    Details
    Publication Date: 2013-06-07
    Description: Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest surgical intervention in children in the developed world. Chronic and recurrent forms of OM are known to have a very significant genetic component, however, until recently little was known of the underlying genes involved. The identification of mouse models of chronic OM has indicated a role of transforming growth factor beta (TGFβ) signalling and its impact on responses to hypoxia in the inflamed middle ear. We have, therefore, investigated the role of TGFβ signalling and identified and characterized a new model of chronic OM carrying a mutation in the gene for transforming growth interacting factor 1 ( Tgif1 ). Tgif1 homozygous mutant mice have significantly raised auditory thresholds due to a conductive deafness arising from a chronic effusion starting at around 3 weeks of age. The OM is accompanied by a significant thickening of the middle ear mucosa lining, expansion of mucin-secreting goblet cell populations and raised levels of vascular endothelial growth factor, TNF-α and IL-1β in ear fluids. We also identified downstream effects on TGFβ signalling in middle ear epithelia at the time of development of chronic OM. Both phosphorylated SMAD2 and p21 levels were lowered in the homozygous mutant, demonstrating a suppression of the TGFβ pathway. The identification and characterization of the Tgif mutant supports the role of TGFβ signalling in the development of chronic OM and provides an important candidate gene for genetic studies in the human population.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 3
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    Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression (2014)
    Oxford University Press
    Details
    Publication Date: 2014-09-17
    Description: Translational control of transcription factor ATF4 through paired upstream ORFs (uORFs) plays an important role in eukaryotic gene regulation. While it is typically induced by phosphorylation of eIF2α, ATF4 translation can be also induced by expression of a translational inhibitor protein, eIF5-mimic protein 1 (5MP1, also known as BZW2) in mammals. Here we show that the 5MP gene is maintained in eukaryotes under strong purifying selection, but is uniquely missing in two major phyla, nematoda and ascomycota. The common function of 5MP from protozoa, plants, fungi and insects is to control translation by inhibiting eIF2. The affinity of human 5MP1 to eIF2β was measured as being equivalent to the published value of human eIF5 to eIF2β, in agreement with effective competition of 5MP with eIF5 for the main substrate, eIF2. In the red flour beetle, Tribolium castaneum , RNA interference studies indicate that 5MP facilitates expression of GADD34, a downstream target of ATF4. Furthermore, both 5MP and ATF4 are essential for larval development. Finally, 5MP and the paired uORFs allowing ATF4 control are conserved in the entire metazoa except nematoda. Based on these findings, we discuss the phylogenetic and functional linkage between ATF4 regulation and 5MP expression in this group of eukaryotes.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 4
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    How does human motor cortex regulate vocal pitch in singers? (2018)
    Royal Society
    Details
    Publication Date: 2018-08-16
    Description: Vocal pitch is used as an important communicative device by humans, as found in the melodic dimension of both speech and song. Vocal pitch is determined by the degree of tension in the vocal folds of the larynx, which itself is influenced by complex and nonlinear interactions among the laryngeal muscles. The relationship between these muscles and vocal pitch has been described by a mathematical model in the form of a set of ‘control rules’. We searched for the biological implementation of these control rules in the larynx motor cortex of the human brain. We scanned choral singers with functional magnetic resonance imaging as they produced discrete pitches at four different levels across their vocal range. While the locations of the larynx motor activations varied across singers, the activation peaks for the four pitch levels were highly consistent within each individual singer. This result was corroborated using multi-voxel pattern analysis, which demonstrated an absence of patterned activations differentiating any pairing of pitch levels. The complex and nonlinear relationships between the multiple laryngeal muscles that control vocal pitch may obscure the neural encoding of vocal pitch in the brain.
    Keywords: neuroscience, behaviour, evolution
    Electronic ISSN: 2054-5703
    Topics: Natural Sciences in General
    Published by Royal Society
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  • 5
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    A global assessment of the effects of climate policy on the impacts of climate change (2013)
    Springer Nature
    Details
    Publication Date: 2013-04-26
    Description: Climate mitigation policies are rarely assessed in terms of the proportion of climate impacts they can avoid both regionally and globally. Research shows that policies with a 50% chance of remaining below a 2 °C rise in temperature may reduce the impacts of climate change by 20–65% by 2100, relative to pathways with a temperature rise of 4 °C. Nature Climate Change 3 512 doi: 10.1038/nclimate1793
    Print ISSN: 1758-678X
    Electronic ISSN: 1758-6798
    Topics: Geosciences
    Published by Springer Nature
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  • 6
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    IGF-1 receptor antagonism inhibits autophagy (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-29
    Description: Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. This pathway is upstream of mTORC1, a negative regulator of autophagy. Thus, we expected autophagy to be activated by insulin-like growth factor-1 (IGF-1) inhibition, which could account for many of its beneficial effects. Paradoxically, we found that IGF-1 inhibition attenuates autophagosome formation. The reduced amount of autophagosomes present in IGF-1R depleted cells can be, at least in part, explained by a reduced formation of autophagosomal precursors at the plasma membrane. In particular, IGF-1R depletion inhibits mTORC2, which, in turn, reduces the activity of protein kinase C (PKCα/β). This perturbs the actin cytoskeleton dynamics and decreases the rate of clathrin-dependent endocytosis, which impacts autophagosome precursor formation. Finally, with important implications for human diseases, we demonstrate that pharmacological inhibition of the IGF-1R signalling cascade reduces autophagy also in zebrafish and mice models. The novel link we describe here has important consequences for the interpretation of genetic experiments in mammalian systems and for evaluating the potential of targeting the IGF-1R receptor or modulating its signalling through the downstream pathway for therapeutic purposes under clinically relevant conditions, such as neurodegenerative diseases, where autophagy stimulation is considered beneficial.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 7
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    The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Neurons have adapted mechanisms to traffic RNA and protein into distant dendritic and axonal arbors. Taking a biochemical approach, we reveal that forebrain synaptic transcript accumulation shows overwhelmingly daily rhythms, with two-thirds of synaptic transcripts showing time-of-day–dependent abundance independent of oscillations in the soma. These transcripts formed two sharp temporal and functional clusters, with transcripts preceding dawn related to metabolism and translation and those anticipating dusk related to synaptic transmission. Characterization of the synaptic proteome around the clock demonstrates the functional relevance of temporal gating for synaptic processes and energy homeostasis. Unexpectedly, sleep deprivation completely abolished proteome but not transcript oscillations. Altogether, the emerging picture is one of a circadian anticipation of messenger RNA needs in the synapse followed by translation as demanded by sleep-wake cycles.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
    Electronic Resource
    Electronic Resource
    The PEP beam line
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 246 (1986), S. 149-153 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(86)90063-X
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    Paper (German National Licenses)
    Fulltext
  • 9
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    LithosphereOPROBE - southern Vancouver island: Cenozoic subduction complex imaged by deep seismic reflections (1987)
    In:  Can. J. Earth Sci., Heidelberg, Institution of Mining and Metallurgy, vol. 24, no. 1, pp. 31-51, pp. 2074, (ISBN: 0-12-018847-3)
    Details
    Publication Date: 1987
    Keywords: Project report/description ; Canada ; Subduction zone ; Deep seismic sounding (espec. cont. crust) ; Reflection seismics
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    BIBLIOGRAPHY SEISMOLOGY
  • 10
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    Facing nuclear reality (1987)
    In:  Science, Luxembourg, Conseil de l'Europe, vol. 238, no. 10, pp. 455, pp. L24308, (ISSN: 1340-4202)
    Details
    Publication Date: 1987
    Keywords: Nuclear explosion
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    BIBLIOGRAPHY SEISMOLOGY
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