ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Single non-lethal doses (3 mmol/kg) of chloroform (CHCl3), dichlorobromomethane (CHCl2Br), dibromochloromethane (CHClBr2), and bromoform (CHBr3) were administered by intraperitoneal injection to male Sprague-Dawley rats and glomerular filtration and renal concentrating ability were assessed at varied times (5–8 h, 21–24 h, and 45–58 h) following treatment. At this dose, each of the four trihalomethanes (THMs) elevated blood urea nitrogen (BUN) and reduced renal concentrating ability (as measured by H2O intake/output ratios, urinary total osmolality, and electrolyte levels). Three of the four THMs also significantly reduced glomerular filtration rate (GFR), with only CHCl3 failing to demonstrate an effect at 3 mmol/kg. In general, CHCl2Br demonstrated the greatest interference with these renal function parameters. The times of maximal THM-induced effect on BUN and glomerular filtration rate were observed to be 24 h and 21–24 h post-treatment, respectively. These data suggest that a single acute THM treatment can inhibit mammalian renal concentrating ability and glomerular filtration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00203878
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