ISSN:
0170-2041
Keywords:
Photodynamic therapy (PDT)
;
Porphyrins
;
Hematoporphyrin derivative (HPD)
;
Mannich bases
;
Benzyl cations
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Natural Tetrapyrrol Derivatives for the Photodynamic Therapy, 2. - Model Reactions for Direct C-C Linkages of PorphyrinsUntil now, there is a lack of information about the structure of the active components in the diagnosis and photodynamic therapy of cancer with hematoporphyrin derivatives (HPD). We describe the formation of HPD in terms of benzyl cation chemistry. Selective formation of the C - C-linked model compounds 4, 5 by reaction of protoporphyrin dimethyl ester (2) with electron-rich aromatic compounds as well as of 9 - 12, 15-17, obtained by reaction of the porphyrin dimethyl esters 2, 6, 7, and 8, with carbon electrophiles (preformed Mannich salts), results from this concept.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199219920199
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