ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Dicyandiamide (DCDA) is used as a chemical additive in the fast atom bombardment (FAB) matrix 3-mercaptopropane-l,2-diol (thioglycerol) and propane-l,2,3-triol (glycerol). It is demonstrated that DCDA can be used to generate adduct ions [M + H + DCDA]+ for a variety of common organic functional groups to confirm the molecular ion [M + H]+. It is particularly useful for aromatic and alkyl amines and these compounds were therefore investigated in greater detail. Primary and secondary amines on heating react with DCDA to produce biguanides. DCDA can be used as a derivatizing reagent, but the reaction times are typically longer than 12 h and, therefore, it has limited utility. Biguanides can be detected at the nanogram level in full-range FAB mass spectral analysis.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210250606
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