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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 10426-10430 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 1 (1996), S. 3-13 
    ISSN: 1432-0517
    Keywords: Key words Traceability ; Mole ; Definition ; Measurements ; Chemical metrology ; Calibration ; Validation ; Reference materials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  By the definition of the mole as a base unit for amount-of-substance measures within the International System of Units (SI), chemists can make chemical measurements in full compliance with established metrological principles. Since the mole requires exact knowledge of the chemical entity, which is often neither available nor of practical relevance to the purpose of the measurement, the SI units of mass or length (for volume) are unavoidable in the expression of results of many chemical measurements. Science, technology, and trade depend upon a huge and ever increasing number and variety of chemical determinations to quantify material composition and quality. Thus, international harmonization in the assessments of processes, procedures, and results is highly desirable and clearly cost effective. The authors, with relevant experience and responsibilities in Europe and America, have found some consensus in the interpretation of the metrological principles for chemical measurements, but believe open discussion should precede wide implementation by chemical communities. In fostering this dialogue, this paper shows, for instance, that more precise interpretation of the definitions for "traceability," "calibration," and "validation" is needed for present-day chemical measurements. Problems that face scientists in making measurements do not all vanish just by adherence to the SI. However, such compliance can improve communication among chemists and metrologists.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 3 (1998), S. 350-350 
    ISSN: 1432-0517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 2 (1997), S. 168-179 
    ISSN: 1432-0517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  The authors propose definitions and terminology for protocols on traceability links, generally to the international system of units, for specific chemical-analytical measurements in accordance with recognized principles of science. These definitions and terms could be useful in science, technology, commerce or law. A chain of such links leads from a measurand in a sample up to a unit in the International System of Units or, if unavailable, to a value on an internationally recognized measurement scale. The quality of such a chain is quantified by combining all recognized uncertainties estimated for all its links. These uncertainties of the measured values arise from many potential error sources. The protocols should give details of specific uses of reference materials, measuring instruments and standard measurement methods.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Accreditation and quality assurance 2 (1997), S. 270-274 
    ISSN: 1432-0517
    Keywords: Key words Traceability ; Protocol analysis ; Reference Material ; Uncertainty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  In continuing their attempt to bring general issues concerned with trustworthy chemical measurements to review and international discussion, the authors propose basic aims and requirements for protocols of chemical-measurement procedures with traceability to the SI or, where this is not possible, to units of internationally recognized measurement scales. Documents describing such protocols could be useful in science, technology, law, or trade. Concepts and definitions for protocols have been introduced in Part I of this contribution. Part II here deals with the development and application of protocols for intended in-laboratory, commercial, national, or international recognition. Protocols deal with measurement methods, instrumentation, and the estimation of uncertainties from all possible sources of measurement errors. Uncertainties define the quality of all links in a traceability chain starting from the value of a measurand in a sample, often through a certified value in a reference material, either to the SI, or – if this is not possible – to a value on a suitable, internationally agreed measurement scale. A protocol may concern itself with the complex interplay between uncertainties, tolerances, and any limit values introduced by the set aims of specific measurements.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Human B and T lymphoblastoid cell lines were shown to synthesize C5. C5 synthesis was quantitated with an enzyme-linked immunosorbent assay (ELISA) that utilized a pool of C5-specific monoclonal antibodies (mAbs). Some level of C5 synthesis was detected in all eight of the B and T cell lines examined. In three of the cell lines, C5 was detected in both culture supernatants and whole cell detergent lysates, whereas in the other five cell lines, C5 was detected only in the cell lysates. Lymphoblastoid cells with both distributions of C5 were shown to synthesis a messenger RNA that was similar in size to the C5 mRNA expressed by the HepG2 hepatoma cell line. Estimates of the concentration of the C5 transcript in poly(A)+ RNA from lymphoblastoid and HepG2 cells suggested that C5 mRNA levels in the lymphoblastoid cell lines were comparable and about one-tenth of the levels in HepG2 cells. Lymphoblastoid C5, isolated by immunoaffinity chromatography from the supernatants of 35S-labeled cultures, had the same subunit composition as plasma-derived C5, but an α subunit of slightly smaller relative mass.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Boston, USA and Oxford, UK : Blackwell Publishers Inc
    Journal of regional science 42 (2002), S. 0 
    ISSN: 1467-9787
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Notes: An explanation for the rank-size distribution for human settlements based on simple stochastic models of settlement formation and growth is presented. Not only does the analysis of the model explain the rank-size phenomenon in the upper tail, it also predicts a reverse rank-size phenomenon in the lower tail. Furthermore it yields a parametric form (the double Pareto-lognormal distribution) for the complete distribution of settlement sizes. Settlement-size data for four regions (two in Spain and two in the U.S.) are used as examples. For these regions the lower tail rank-size property is seen to hold and the double Pareto-lognormal distribution shown to provide an excellent fit, lending support to the model and to the explanation for the rank-size law.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 356 (1980), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 52 (1990), S. 583-596 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
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