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  • 1
    Electronic Resource
    Electronic Resource
    Genomic organization, chromosomal mapping, and analysis of the 5’ promoter region of the human MAdCAM-1 gene (1997)
    Springer
    Immunogenetics 46 (1997), S. 111-119 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  MAdCAM-1, the endothelial addressin cell adhesion molecule-1, interacts preferentially with the leukocyte β7 integrin LPAM-1 (α4β7), but also with L-selectin, and with VLA-4 (α4β1) on myeloid cells, and serves to direct leukocytes into mucosal and inflamed tissues. Overlapping cosmid and phage λ genomic clones were isolated, revealing that the human MAdCAM-1 gene contains five exons where the signal peptide, two Ig domains, and mucin domain are each encoded by separate exons. The transmembrane domain, cytoplasmic domain, and 3′ untranslated region are encoded together on exon 5. The mucin domain contains eight repeats in total that are subject to alternative splicing. Despite the absence of a human counterpart of the third IgA-homologous domain and lack of sequence conservation of the mucin domain, the genomic organizations of the human and mouse MAdCAM-1 genes are similar. An alternatively spliced MAdCAM-1 variant was identified that lacks exon 4 encoding the mucin domain, and may mediate leukocyte adhesion to LPAM-1 without adhesion to the alternate receptor, L-selectin. The MAdCAM-1 gene was located at p13.3 on chromosome 19, in close proximity to the ICAM-1 and ICAM-3 genes (p13.2-p13.3). PMA-inducible promotor activity was contained in a 700 base pair 5’ flanking fragment conserved with the mouse MAdCAM-1 gene including tandem NF-kB sites, and an Sp1 site; and in addition multiple potential AP2, Adh1 (ETF), PEA3, and Sp1 sites. In summary, the data establish that the previously reported human MAdCAM-1 cDNA does indeed encode the human homologue of mouse MAdCAM-1, despite gross dissimilarities in the MAdCAM-1 C-terminal structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050249
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Progress in open archives and institutional repositories: growing the Woods Hole Open Access Server (WHOAS) (2008)
    IAMSLIC
    Details
    Publication Date: 2022-05-25
    Description: pp. 109-111
    Repository Name: Woods Hole Open Access Server
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  • 3
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    Aquatic Commons update (2010)
    IAMSLIC
    Details
    Publication Date: 2022-05-25
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
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    MBLWHOI Library Report January 1, 2017 – December 31, 2017 (2018)
    MBLWHOI Library
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    Publication Date: 2022-05-25
    Repository Name: Woods Hole Open Access Server
    Type: Other
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  • 5
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    2019 IODE Update: AIUs, ODISCat, OceanDocs (2020)
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    Publication Date: 2022-05-25
    Description: This presentation gives an overview of current IODE projects that intersect with IAMSLIC interests. This includes an update on the Associated Data Units program for eligible Library and Information Centers.
    Keywords: International Oceanographic Data and Information Exchange (IODE), Associated Data Unit (AIU), ODISCat, Ocean Best Practices.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 6
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    The Future of Aquatic Commons: Recommendations Based on an Evaluation of Business Models and Stakeholder Consultation (2020)
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    Publication Date: 2022-05-25
    Description: Aquatic Commons is a digital repository established by the International Association of Aquatic and Marine Libraries and Information Centers (IAMSLIC) in 2007 to provide a solution for member institutions that didn’t have an institutional repository. It is directed by the Aquatic Commons Board, and submissions are reviewed by an editorial team. Originally hosted by the Florida Center for Library Automation (FCLA), the repository was moved to the International Oceanographic Data and Information Exchange (IODE) in 2011 when FCLA faced major budgetary issues. Aquatic Commons has grown to more than 20,000 publications from over 90 institutions in all areas of the aquatic sciences, including freshwater, fisheries, and oceanography, yet support for the repository has not kept pace with developmental needs. To ensure a sustainable future, the Aquatic Commons Board determined it was necessary to conduct an evaluation and created the Aquatic Commons Evaluation (ACE) team. The team identified and compared four potential business models: 1a) maintain Aquatic Commons as a separate repository but upgrade the EPrints software; 1b) maintain Aquatic Commons as a separate repository but migrate to DSpace software; 2) migrate content to the existing IODE OceanDocs repository but retain Aquatic Commons identity by having a separate DSpace community; and 3) partner with IODE and possibly the Aquatic Science and Fisheries Abstracts (ASFA) to create an entirely new repository with content merged from Aquatic Commons and OceanDocs. The team consulted with potential partners (e.g. ASFA and IODE) and ran a survey to elicit feedback from members, depositors, and other stakeholders about the models, addressing issues of thematic scope, branding, software, technical requirements, workflows, and training. At the 2019 conference, the team presented a recommendation based on the evaluation in order to initiate a roadmap for the Aquatic Commons.
    Keywords: Aquatic Commons, OceanDocs, IODE, Open Access, DSpace, Eprints, Survey
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 7
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    Dataset to DOI using SWORD [poster] (2012)
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    Publication Date: 2022-05-25
    Description: Poster session, March 12, 2012, SPARC (The Scholarly Publishing and Academic Resources Coalition) Open Access Meeting, Kansas City, MO, March 12-13, 2012
    Description: This poster describes the tools and processes by which datasets are deposited in an institutional repository (IR) and digital object identifiers (DOI) are acquired. The Marine Biological Laboratory/Woods Hole Oceanographic Institution (MBLWHOI) Library and the Biological and Chemical Oceanography Data Management Office (BCO-DMO) have developed tools and processes to automate the ingestion of datasets and metadata from BCO-DMO for deposit into the Woods Hole Open Access Server (WHOAS) institutional repository. The system also incorporates functionality for BCO-DMO to request a DOI from the Library and streamlines the process by which XML files are generated for DOI deposit with CrossRef, a DOI registration agency. This partnership allows the Library to work with a trusted data repository to ensure high quality data while the data repository utilizes library services and is assured of a permanent archive of the copy of the data extracted from the repository database. This research is being conducted by a team of librarians, data managers and scientists that are collaborating with representatives from the Scientific Committee on Oceanic Research (SCOR) and the International Oceanographic Data and Information Exchange (IODE) of the Intergovernmental Oceanographic Commission (IOC).
    Repository Name: Woods Hole Open Access Server
    Type: Presentation
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  • 8
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    Data publication (2013)
    IAMSLIC
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    Publication Date: 2022-05-25
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 9
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    Facilitating open exchange of data and information (2015)
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Earth Science Informatics 8 (2015): 721-739, doi:10.1007/s12145-014-0202-2.
    Description: By broad consensus, Open Data presents great value. However, beyond that simple statement, there are a number of complex, and sometimes contentious, issues that the science community must address. In this review, we examine the current state of the core issues of Open Data with the unique perspective and use cases of the ocean science community: interoperability; discovery and access; quality and fitness for purpose; and sustainability. The topics of Governance and Data Publication are also examined in detail. Each of the areas covered are, by themselves, complex and the approaches to the issues under consideration are often at odds with each other. Any comprehensive policy on Open Data will require compromises that are best resolved by broad community input. In the final section of the review, we provide recommendations that serve as a starting point for these discussions.
    Description: The authors acknowledge the support of the National Science Foundation through Grant Award No. OCE-1143683.
    Description: 2016-01-07
    Keywords: Open Data ; Interoperability ; Governance ; Data publication
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 10
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    Report of the Research Coordination Network RCN : OceanObsNetwork, facilitating open exchange of data and information (2013)
    NSF/Ocean Research Coordination Network
    Details
    Publication Date: 2022-05-25
    Description: The OceanObsNetwork goals and objectives are to foster a broad, multi-disciplinary dialogue, enabling more effective use of sustained ocean observatories and observing systems. To achieve these, the activities for the RCN include a working group titled “Facilitating Open Exchange of Data and Information.” Within this area 3 task teams were created dealing with elements that impact on open exchange of data and information. This report examines the foundation of Open Data and its importance to the international community, science, innovation and jobs. While the goal may be similar, the paths to Open Data are varied and drawing together a pervasive approach will take time. There are however, near term steps, technical and social, that could have significant impacts. Stimulating interdisciplinary collaboration occurs through adoption of common standards for data exchange, creation of information brokering for improved discovery and access and working toward common or defined vocabularies. Simply finding other scientists’ data has been noted as a major barrier for research. Open Data impinges on existing reward systems and social interactions. Areas that need to be addressed are the academic reward system (in terms of promotion and resources), the peer review panels and grant selection processes (in terms of acknowledging the importance and challenge of data collection) and the needs for acceptable citation mechanisms. Intellectual property should not be abandoned in an Open Data environment and managing IPR is necessary. A sustainable Open Data Policy is essential and sustainability is a matter for all parties, government, private sector, academia and non-profit organizations. As full implementation of Open Data will involve a change in practices in a number of research and publication activities, an end-to-end perspective and strategy would most likely allow a long-term sustainable path to be pursued. Various business models are discussed in the paper that would not have been considered a decade ago. These range from cloud storage to publication of data with Digital Object Identifiers. These set a possible foundation for the future.
    Description: National Science Foundation through Grant Award No. OCE-1143683.
    Repository Name: Woods Hole Open Access Server
    Type: Working Paper
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