Publication Date:
2011-02-02
Description:
The immune system includes a subpopulation of CD8+ T cells equipped to inhibit the expansion of follicular T helper (TFH) cells, resulting in suppression of autoantibody production and associated lupus-like disease. These CD8+ T regulatory (Treg) cells recognize Qa-1/peptide complexes on target TFH cells and depend on the IL-15 cytokine for development and function. Here we show that these CD8+ Treg cells express a triad of surface receptors—CD44, CD122, and the class I MHC receptor Ly49—and account for
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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