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  • 1
    Publication Date: 2019
    Description: 〈p〉Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (T〈sub〉H〈/sub〉)1 and T〈sub〉H〈/sub〉17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin–specific T〈sub〉H〈/sub〉17 cells imprinted in the intestine by a commensal 〈i〉Bacteroides〈/i〉 species peptide mimic. Both the successful prevention of lethal disease in mice by antibiotic therapy and the significantly elevated 〈i〉Bacteroides-〈/i〉specific CD4〈sup〉+〈/sup〉 T cell and B cell responses observed in human myocarditis patients suggest that mimic peptides from commensal bacteria can promote inflammatory cardiomyopathy in genetically susceptible individuals. The ability to restrain cardiotoxic T cells through manipulation of the microbiome thereby transforms inflammatory cardiomyopathy into a targetable disease.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-12-17
    Description: Author(s): D. S. Delion, R. J. Liotta, Chong Qi, and R. Wyss We analyze the α-decay fine structure to excited 0 2 + states in Hg and Rn isotopes. These states are described as minima in the potential energy surface (PES) provided by the standard deformed Woods-Saxon plus pairing approach. We also investigate α decay from the excited state P(0 2 + ) in the parent n... [Phys. Rev. C 90, 061303] Published Tue Dec 16, 2014
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 3
    Publication Date: 2014-01-29
    Description: Author(s): H. Jiang, Y. Lei, C. Qi, R. Liotta, R. Wyss, and Y. M. Zhao The magnetic moments of the first excited 2+ state in even-even nuclei 102–130Sn and the low-lying yrast states in odd-mass nuclei 101–109,123–131Sn are calculated within the framework of the nucleon-pair approximation (NPA) of the shell model, by using the standard multipole-multipole interaction. ... [Phys. Rev. C 89, 014320] Published Mon Jan 27, 2014
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 4
    Publication Date: 2016-09-17
    Description: We performed systematic flume experiments using natural bedload particles to quantify the effect of different parameters on the signal registered by the Swiss plate geophone, a bedload surrogate monitoring system. It was observed that the number of impulses computed from the raw signal clearly depends on bed particle size, mean flow velocity, bed roughness, and to a minor extent on particle shape. The centroid frequency of the signal resulting from the collision of a bedload particle against the geophone plate was found to be inversely related to particle size but to be less sensitive to variations in mean flow velocity and bed roughness than the signal amplitude, which is also related to particle size. Combining frequency and amplitude information resulted in a more robust identification of the transported particles size over a wide range of sizes than using amplitude information alone. This article is protected by copyright. All rights reserved.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
    Publication Date: 2016-09-17
    Description: The Swiss plate geophone is a bedload surrogate monitoring system that had been calibrated in several gravel-bed streams through field calibration measurements. Field calibration measurements are generally expensive and time consuming, therefore we investigated the possibility to replace it by a flume-based calibration approach. We applied impulse-diameter relations for the Swiss plate geophone obtained from systematic flume experiments to field calibration measurements in four different gravel-bed streams. The flume-based relations were successfully validated with direct bedload samples from field measurements, by estimating the number of impulses based on observed bedload masses per grain size class. We estimated bedload transport mass by developing flume-based and stream-dependent calibration procedures for the Swiss plate geophone system using an additional empirical function. The estimated masses are on average in the range of ±90% of measured bedload masses in the field, but the accuracy is generally improved for larger transported bedload masses. We discuss the limitations of the presented flume-based calibration approach. This article is protected by copyright. All rights reserved.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 6
    Publication Date: 2015-11-06
    Description: Author(s): D. S. Delion, R. J. Liotta, and R. Wyss We compare the quantum mechanical procedures to estimate the total α -decay width from deformed nuclei in the laboratory and intrinsic systems of coordinates. Our analysis shows that the total half-life estimated in the intrinsic frame by neglecting the rotational motion of the core (adiabatic approa… [Phys. Rev. C 92, 051301(R)] Published Thu Nov 05, 2015
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 7
    Publication Date: 2014-08-15
    Description: Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly understood. Here we present the X-ray structure of a mammalian Cys-loop receptor, the mouse serotonin 5-HT3 receptor, at 3.5 A resolution. The structure of the proteolysed receptor, made up of two fragments and comprising part of the intracellular domain, was determined in complex with stabilizing nanobodies. The extracellular domain reveals the detailed anatomy of the neurotransmitter binding site capped by a nanobody. The membrane domain delimits an aqueous pore with a 4.6 A constriction. In the intracellular domain, a bundle of five intracellular helices creates a closed vestibule where lateral portals are obstructed by loops. This 5-HT3 receptor structure, revealing part of the intracellular domain, expands the structural basis for understanding the operating mechanism of mammalian Cys-loop receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hassaine, Gherici -- Deluz, Cedric -- Grasso, Luigino -- Wyss, Romain -- Tol, Menno B -- Hovius, Ruud -- Graff, Alexandra -- Stahlberg, Henning -- Tomizaki, Takashi -- Desmyter, Aline -- Moreau, Christophe -- Li, Xiao-Dan -- Poitevin, Frederic -- Vogel, Horst -- Nury, Hugues -- England -- Nature. 2014 Aug 21;512(7514):276-81. doi: 10.1038/nature13552. Epub 2014 Aug 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉1] Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland [2] [3] Theranyx, 163 Avenue de Luminy, 13288 Marseille, France. ; 1] Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland [2]. ; Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland. ; Center for Cellular Imaging and NanoAnalytics, Biozentrum, University of Basel, CH-4058 Basel, Switzerland. ; Swiss Light Source, Paul Scherrer Institute, CH-5234 Villigen, Switzerland. ; Architecture et Fonction des Macromolecules Biologiques, CNRS UMR 7257 and Universite Aix-Marseille, F-13288 Marseille, France. ; 1] Universite Grenoble Alpes, IBS, F-38000 Grenoble, France [2] CNRS, IBS, F-38000 Grenoble, France [3] CEA, DSV, IBS, F-38000 Grenoble, France. ; Laboratory of Biomolecular Research, Paul Scherrer Institute, CH-5232 Villigen, Switzerland. ; Unite de Dynamique Structurale des Macromolecules, Institut Pasteur, CNRS UMR3528, F-75015 Paris, France. ; 1] Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Federale de Lausanne, CH-1015 Lausanne, Switzerland [2] Universite Grenoble Alpes, IBS, F-38000 Grenoble, France [3] CNRS, IBS, F-38000 Grenoble, France [4] CEA, DSV, IBS, F-38000 Grenoble, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25119048" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Binding Sites ; Crystallography, X-Ray ; Mice ; Models, Molecular ; Molecular Sequence Data ; Neurotransmitter Agents/metabolism ; Protein Structure, Quaternary ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Receptors, Serotonin, 5-HT3/*chemistry/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2012-10-13
    Description: Author(s): A. Bhagwat, X. Viñas, M. Centelles, P. Schuck, and R. Wyss The binding energies of deformed even-even nuclei have been analyzed within the framework of a recently proposed microscopic-macroscopic model. We have used the semiclassical Wigner-Kirkwood ℏ expansion up to fourth order, instead of the usual Strutinsky averaging scheme, to compute the shell correc... [Phys. Rev. C 86, 044316] Published Fri Oct 12, 2012
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 9
    Publication Date: 2013-03-23
    Description: Author(s): T. Bäck, C. Qi, B. Cederwall, R. Liotta, F. Ghazi Moradi, A. Johnson, R. Wyss, and R. Wadsworth Recent B ( E 2;0 g.s. + →2 1 + ) measurements in light tin isotopes have revealed surprisingly large values relative to standard shell model predictions, generating an unexpected asymmetry in the B ( E 2) values with respect to the neutron midshell. This effect has triggered various speculations as to its origi... [Phys. Rev. C 87, 031306] Published Fri Mar 22, 2013
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
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  • 10
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    American Physical Society (APS)
    Publication Date: 2013-03-29
    Description: Author(s): D. S. Delion, R. J. Liotta, and R. Wyss The two-proton decay process is studied by using a simple approach within the framework of scattering theory. We assume that the decaying nucleus is in a pairing state and, therefore, the two-particle wave function on the nuclear surface corresponds to the two protons moving in time-reversed states.... [Phys. Rev. C 87, 034328] Published Thu Mar 28, 2013
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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