ISSN:
1420-9071
Keywords:
NW-nitro-l-arginine methyl ester
;
nitric oxide
;
cold-restraint stress
;
mucosal ulcers
;
mast cells
;
rat stomachs
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Treatment 20 min beforehand with an inhibitor of nitric oxide (NO) synthesis, NW-nitro-l-arginine methyl ester (L-NAME) (12.5, 25, 50 or 100 mg/kg, s.c.), dose-dependently intensified gastric glandular mucosal ulceration produced by cold-restraint stress. Hexamethonium (20 mg/kg) or atropine (1 mg/kg) pretreatment s.c. 20 min before stress strongly antagonised stress-evoked ulceration, as well as the ulcer-potentiating effects of L-NAME when either cholinoceptor antagonist was given concurrently with the NO inhibitor. Stress-induced mast cell degranulation was not worsened by L-NAME pretreatment. The findings suggest that NO could confer partial protection against stress-induced gastric ulcer formation; its activity is triggered off by the ulcerogenic mechanism of stress.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923407
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