geriatric drug metabolism
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Summary To examine whether a drug-metabolizing enzyme changes with normal aging, the S:R index of S-mephenytoin 4-hydroxylation was determined in 150, unmedicated elderly Americans (mean age 75.4). Ten (6.7%) were identified as categorically slow metabolizers (S:R ratios ≥.95). This increased incidence of slow metabolizers was accounted for by a significant and previously unreported, increased proportion of slow metabolizers among the black (18.5%) as compared to the white subjects (4.1%) (P=.017). There was no relationship found between S:R ratios and age or creatinine clearance.
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