Anionic glycine equivalent
Palladium-induced reductive coupling
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Synthetic approaches to bicyclic and tricyclic α,α-disubstituted α-amino acids and derivatives 6, 8, 10, 12, 13, 21, 22, 23, 24, 28, 30, and 31 are presented. Methyl acetoacetate, ethyl nitroacetate, and ethyl N-(diphenylmethylene)glycinate are compared as anionic glycine equivalents. Palladium-induced reductive couplings, Diels-Alder and Pauson-Khand reactions are used in the cyclisation steps.
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