ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The major histocompatibility complexes (B complexes) of chickens of various origins have been studied by serological and biochemical methods. TwoB complexes are of particular interest:B R1, a recombinant haplotype derived from theB complexes of the inbred CB and CC strains, andB G-B1 , theB haplotype of the G-B1 strain. TheB R1 haplotype differs detectably from theB CB haplotype only at a locus controlling the synthesis of an antigen, B-G, which (in peripheral blood) is present only on red cells. Anti-B-G sera precipitate, from125I-labeled red cell lysates, two chains of apparent molecular weights 42,000 and 31,000 (measured under reducing conditions); the smaller is perhaps derived by proteolysis from the larger. TheB G-B1 haplotype differs detectably from theB CC haplotype only at a locus controlling the synthesis of an antigen whose tissue distribution and biochemical and biological properties are identical to those of B-G. The chicken major histocompatibility complex therefore contains at least three loci—those controlling synthesis of the B-G, and of the previously defined B and B-L antigens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01570477
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