ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A sensitive and specific method is described for the determination of 1,2,3,4-tetrahydro-β-carboline in human plasma, based on selected ion monitoring gas chromatography mass spectrometry and employing a deuterium analogue as internal standard. The identification of 1,2,3,4-tetrahydro-β-carboline is based on monitoring ions m/z 143, 171,199 and 368 for the heptafluorobutyryl derivative of 1,2,3,4-tetrahydro-β-carboline or the normal mass spectrum. For quantitation the ratio of ions m/z 368/370 was used. The mean of 1,2,3,4-tetrahydro-β-carboline level in human plasma (n = 10) was 8.78± 1.94 ng ml-1 and 5.68±1.34 ng in platelets corresponding 1 ml of platelet rich plasma.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200071120
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