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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 31 (1990), S. 1559-1562 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2014-05-28
    Description: Uncoupling protein 1 (Ucp1), which is localized in the mitochondrial inner membrane of mammalian brown adipose tissue (BAT), generates heat by uncoupling oxidative phosphorylation. Upon cold exposure or nutritional abundance, sympathetic neurons stimulate BAT to express Ucp1 to induce energy dissipation and thermogenesis. Accordingly, increased Ucp1 expression reduces obesity in...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2016-04-23
    Description: This study was conducted to analyze the gene expression of prognostic potential biomarker candidates using the whole blood of cattle naturally infected with Mycobacterium avium subsp. paratuberculosis (MAP). We conducted real-time PCR to evaluate 23 potential biomarker candidates. Experimental animals were divided into four groups based on fecal MAP PCR and serum ELISA. Seven ( KLRB1 , HGF , MPO , LTF , SERPINE1 , S100A8 and S100A9 ) genes were up-regulated in fecal MAP-positive cattle and three ( KLRB1 , MPO and S100A9 ) were up-regulated in MAP-seropositive cattle relative to uninfected cattle. In subclinically infected animals, 17 genes ( TFRC , S100A8 , S100A9 , MPO , GBP6 , LTF , KLRB1 , SERPINE1 , PIGR , IL-10 , CXCR3 , CD14 , MMP9 , ELANE , CHI3L1 , HP and HGF ) were up-regulated compared with the control group. Moreover, six genes ( CXCR3 , HP , HGF , LTF , TFRC and GBP6 ) showed significant differences between experimental groups. Taken together, our data suggest that six genes ( LTF , HGF , HP , CXCR3 , GBP6 and TFRC ) played essential roles in the immune response to MAP during the subclinical stage and therefore might be useful as prognostic biomarkers.
    Print ISSN: 0928-8244
    Topics: Biology , Medicine
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  • 4
    ISSN: 1573-8922
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Tests of cross-ply composite tubes were performed under combined axial and torsional loading up to failure. Strength properties and failure mechanisms were evaluated with reference to the biaxiality ratio of the loading. The scattering of the biaxial strength data was analyzed using the Weibull distribution. The axial contraction of carbon fiber-reinforced plastic (CFRP) tubes under biaxial loading was investigated theoretically and experimentally. Artificial neural networks were introduced to predict the failure strength using the algorithm of the error back-propagation. The prediction was also made by the Tsai-Wu theory using the experimental data and by the combined optimized tensor-polynomial theory. A comparison shows that the artificial neural network has the smallest root-mean square (RMS) error of the three prediction methods. The prediction of the axial contraction of the tubes correlates well with the results of a linear variable differential transformer (LVDT) of the testing machine. From the phenomenological analysis of the failure and the fractographic observations of the fracture surface, three types of failure modes and microscopic failure were investigated, depending on the biaxiality ratio, and the corresponding failure mechanisms are suggested.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-8922
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A method is presented for maximum strength optimum design of symmetric composite laminates subjected to in-plane and transverse loadings. The finite element method based on shear deformation theory is used for the analysis of composite laminates. Ply orientation angles are chosen as design variables. The quadratic failure criterion which is meant to predict fracture, is used as an object function for optimum stacking sequence design of a laminated plate. The Broydon-Fletcher-Goldfarb-Shanno optimization technique is employed to solve the optimization problem effectively. Numerical results are given for various loading conditions, boundary conditions, and aspect ratios. The results show that the quadratic failure criterion such as Tsai-Hill theory is effective for the optimum structural design of composite laminates.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In order to determine the operating condition of an uranium chlorination process with U3O8-C-Cl2 system, the experimental conditions have been evaluated preliminarily by the thermochemical analysis and experimentally confirmed in this study. The dry-type chlorination of U3O8 occurs as irreversible and exothermic reaction and produces many kinds of chloride compounds such as UCl3, UCl4, UCl5 and UCl6 in the air and humidity controlled argon environment. Taking account of Gibbs free energy and vapor pressure for various chloride compounds, the proper temperature range of chlorination appears to be 863 to 953 K in aspects of increasing reaction rate and the yield of nonvolatile product. In the course of the experimental confirmation the powder of U3O8 is perfectly converted into uranium chlorides within 4 hours above 863K, and then the maximum fraction of uranium chloride remaining in the reactor is about 30% of total conversion mass.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A study on the separation of lithium isotopes was carried out with 1,13-dioxa-4,7,10-triazacyclopentadecane-4,7,10-trimerrifield peptide resin [N3O23M]. The resin having N3O2 as an anchor group has a capacity of 0.2 meq/g dry resin. Upon column chromatography [0.1 cm (I.D)×30 cm (height)] using 1.0M NH4Cl solution as an eluent, a single separation factor of 1.00104 was obtained from the elution curve and isotope ratios based on theGlueckauf theory. The heavier isotope,7Li concentrated in the resin phase, while the lighter isotope,6Li enriched in the solution phase.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 34 (1994), S. 148-154 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract This study explores the potential for application of laser-induced surface or Rayleigh waves on graphite/epoxy composites. Rayleigh waves were generated by a Q-switched ruby laser in the ablation regime and detected by a pinducer which permitted accurate phase-velocity measurements. The Rayleigh wave velocity was measured in various directions relative to the fiber direction. Experimental results agreed closely with numerical predictions in the thick plate, but showed some increase of phase velocity in the thin plate. Laser-generated Rayleigh waves, particularly along the fiber direction, showed good potential for applications in NDT.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0044-2275
    Keywords: Key words. Inverse heat transfer problem, Karhunen—Loève Galerkin method.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract. An efficent method of solving the inverse heat transfer problem of estimating the unknown function of wall heat flux for laminar flow inside a duct is proposed in the present paper. It is based on the Karhunen—Loève Galerkin procedure which employs the empirical eigenfunctions of the Karhunen—Loève decomposition as basis functions of a Galerkin procedure. With the empirical eigenfunctions, one can a priori limit the function space considered to the smallest linear subspace that is sufficient to describe the observed phenomena, and thus convert the governing equations to a model with a minimum degree of freedom, resulting in a drastic reduction of computation time without loss of accuracy. The performance of the present technique of inverse analysis using the Karhunen—Loève Galerkin procedure is evaluated by several numerical experiments, and is found to be very accurate as well as efficient.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In order to remove the radiotoxic nuclides, Cs+ and I−, from low-level liquid wastes, the adsorption characteristics have been studied using a mixed adsorbent of chabazite zeolite and activated carbon. The equilibrium data of each nuclide were well correlated with the DA equation in the wide range of equilibrium concentrations. The SEM-EDAX analysis provided precise understanding of the adsorption mechanism of each nuclide. A surface diffusion model was applied to estimate the intraparticle mass transfer and provided prediction results acceptable for practical implementation in the liquid waste treatment.
    Type of Medium: Electronic Resource
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